BindingDB PrimarySearch

null

SMILES: NC(=O)c1cccnc1

InChI Key: InChIKey=DFPAKSUCGFBDDF-UHFFFAOYSA-N

PDB links: 70 PDB IDs match this monomer. 1155 PDB IDs contain this monomer as substructures.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 54 hits for monomerid = 27507
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Coagulation factor VII/Tissue factor (Homo sapiens (Human))	BDBM27507 (3-Pyridinecarboxamide \| CHEMBL1140 \| NAM \| niacina...) Show SMILES NC(=O)c1cccnc1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	8.00E+6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Co. Curated by ChEMBL					Assay Description Inhibition of human soluble tissue factor/factor VIIa expressed in Origami B (DE3) using D-Ile-Pro-Arg-pNA as substrate after 30 mins by spectrophoto...				J Med Chem 58: 2799-808 (2015) Article DOI: 10.1021/jm501982k BindingDB Entry DOI: 10.7270/Q28D007C
Bristol-Myers Squibb Co. Curated by ChEMBL					More data for this Ligand-Target Pair
NAD-dependent protein deacylase sirtuin-5, mitochondrial (Homo sapiens (Human))	BDBM27507 (3-Pyridinecarboxamide \| CHEMBL1140 \| NAM \| niacina...) Show SMILES NC(=O)c1cccnc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human recombinant SIRT5 assessed as inhibition of substrate desuccinylation using Fluor de Lys-Succinyl green peptide as substrate in p...				Citation and Details Article DOI: 10.1016/j.bmc.2021.116328 BindingDB Entry DOI: 10.7270/Q23F4TGR
TBA					More data for this Ligand-Target Pair
NAD-dependent protein deacylase sirtuin-6 (Homo sapiens (Human))	BDBM27507 (3-Pyridinecarboxamide \| CHEMBL1140 \| NAM \| niacina...) Show SMILES NC(=O)c1cccnc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	1.89E+5	n/a	n/a	n/a	n/a	n/a	n/a
University at Albany					Assay Description Inhibitory constants (Ki) and IC50 values were determined under saturating substrate conditions by using a fluorimetric assay (components were purcha...				Chembiochem 18: 931-940 (2017) Article DOI: 10.1002/cbic.201600655 BindingDB Entry DOI: 10.7270/Q2CJ8CC2
University at Albany					More data for this Ligand-Target Pair				3D Structure (crystal)
NAD-dependent protein deacetylase sirtuin-2 (Homo sapiens (Human))	BDBM27507 (3-Pyridinecarboxamide \| CHEMBL1140 \| NAM \| niacina...) Show SMILES NC(=O)c1cccnc1 Show InChI	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	1.05E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of full length human SIRT2 expressed in Escherichia coli BL21 (DE3) cells using fluorogenic 7-amino-4-methylcoumarin (AMC)-labeled peptide...				J Med Chem 57: 8340-57 (2014) Article DOI: 10.1021/jm500777s BindingDB Entry DOI: 10.7270/Q2KK9DDH
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM27507 (3-Pyridinecarboxamide \| CHEMBL1140 \| NAM \| niacina...) Show SMILES NC(=O)c1cccnc1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	7.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of full length human SIRT1 expressed in Escherichia coli BL21 (DE3) cells using fluorogenic 7-amino-4-methylcoumarin (AMC)-labeled peptide...				J Med Chem 57: 8340-57 (2014) Article DOI: 10.1021/jm500777s BindingDB Entry DOI: 10.7270/Q2KK9DDH
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-3, mitochondrial (Homo sapiens (Human))	BDBM27507 (3-Pyridinecarboxamide \| CHEMBL1140 \| NAM \| niacina...) Show SMILES NC(=O)c1cccnc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	6.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of catalytically active human SIRT3 (102 to 399 amino acids) expressed in Escherichia coli BL21 (DE3) cells using fluorogenic 7-amino-4-me...				J Med Chem 57: 8340-57 (2014) Article DOI: 10.1021/jm500777s BindingDB Entry DOI: 10.7270/Q2KK9DDH
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-2 (Homo sapiens (Human))	BDBM27507 (3-Pyridinecarboxamide \| CHEMBL1140 \| NAM \| niacina...) Show SMILES NC(=O)c1cccnc1 Show InChI	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
The University of Tokyo Curated by ChEMBL					Assay Description Inhibition of human recombinant SIRT2				Bioorg Med Chem 23: 328-39 (2015) Article DOI: 10.1016/j.bmc.2014.11.027 BindingDB Entry DOI: 10.7270/Q2736SJS
The University of Tokyo Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
NAD-dependent protein deacetylase sirtuin-2 (Homo sapiens (Human))	BDBM27507 (3-Pyridinecarboxamide \| CHEMBL1140 \| NAM \| niacina...) Show SMILES NC(=O)c1cccnc1 Show InChI	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	1.01E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Kuopio Curated by ChEMBL					Assay Description Inhibition of human recombinant GST-tagged SIRT2 by histone deacetylase assay				J Med Chem 47: 6292-8 (2004) Article DOI: 10.1021/jm049933m BindingDB Entry DOI: 10.7270/Q2S1820Z
University of Kuopio Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
NAD-dependent protein deacylase sirtuin-5, mitochondrial (Homo sapiens (Human))	BDBM27507 (3-Pyridinecarboxamide \| CHEMBL1140 \| NAM \| niacina...) Show SMILES NC(=O)c1cccnc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Guiyang Medical University Curated by ChEMBL					Assay Description Inhibition of human SIRT5 assessed as reduction in desuccinylase activity using KQTAR(SuK)STGGKA substrate				Bioorg Med Chem Lett 25: 1671-4 (2015) Article DOI: 10.1016/j.bmcl.2015.03.018 BindingDB Entry DOI: 10.7270/Q2MK6FKB
Guiyang Medical University Curated by ChEMBL					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM27507 (3-Pyridinecarboxamide \| CHEMBL1140 \| NAM \| niacina...) Show SMILES NC(=O)c1cccnc1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.49E+5	n/a	n/a	n/a	n/a	n/a	n/a
National University of Singapore Curated by ChEMBL					Assay Description Inhibition of human recombinant SIRT1 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l...				Eur J Med Chem 92: 145-55 (2015) Article DOI: 10.1016/j.ejmech.2014.12.027 BindingDB Entry DOI: 10.7270/Q270834V
National University of Singapore Curated by ChEMBL					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-2 (Homo sapiens (Human))	BDBM27507 (3-Pyridinecarboxamide \| CHEMBL1140 \| NAM \| niacina...) Show SMILES NC(=O)c1cccnc1 Show InChI	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	6.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
National University of Singapore Curated by ChEMBL					Assay Description Inhibition of human recombinant SIRT2 assessed as deacetylation of N-acetyl lysine residue in p53 (317 to 320) after 30 mins by luciferase-mediated l...				Eur J Med Chem 92: 145-55 (2015) Article DOI: 10.1016/j.ejmech.2014.12.027 BindingDB Entry DOI: 10.7270/Q270834V
National University of Singapore Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
NAD-dependent protein deacylase sirtuin-6 (Homo sapiens (Human))	BDBM27507 (3-Pyridinecarboxamide \| CHEMBL1140 \| NAM \| niacina...) Show SMILES NC(=O)c1cccnc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	1.84E+5	n/a	n/a	n/a	n/a	n/a	n/a
Guiyang Medical University Curated by ChEMBL					Assay Description Inhibition of SIRT6 (unknown origin) using AMC containing peptide substructure by fluorogenic assay				Eur J Med Chem 96: 245-9 (2015) Article DOI: 10.1016/j.ejmech.2015.04.008 BindingDB Entry DOI: 10.7270/Q2FT8NRP
Guiyang Medical University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
NAD-dependent protein deacylase sirtuin-6 (Homo sapiens (Human))	BDBM27507 (3-Pyridinecarboxamide \| CHEMBL1140 \| NAM \| niacina...) Show SMILES NC(=O)c1cccnc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	2.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Guiyang Medical University Curated by ChEMBL					Assay Description Inhibition of SIRT6 (unknown origin) using (DABCYL)ISGASE(MyK)DIVHSE(EDANS)G substrate in presence of NAD followed by 1 hr incubation with trypsin by...				Eur J Med Chem 96: 245-9 (2015) Article DOI: 10.1016/j.ejmech.2015.04.008 BindingDB Entry DOI: 10.7270/Q2FT8NRP
Guiyang Medical University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM27507 (3-Pyridinecarboxamide \| CHEMBL1140 \| NAM \| niacina...) Show SMILES NC(=O)c1cccnc1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2.10E+5	n/a	n/a	n/a	n/a	n/a	n/a
Peking University Curated by ChEMBL					Assay Description Inhibition of PARP1 (unknown origin)				Bioorg Med Chem Lett 25: 2340-4 (2015) Article DOI: 10.1016/j.bmcl.2015.04.013 BindingDB Entry DOI: 10.7270/Q2N58P2F
Peking University Curated by ChEMBL					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM27507 (3-Pyridinecarboxamide \| CHEMBL1140 \| NAM \| niacina...) Show SMILES NC(=O)c1cccnc1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	5.20E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Akron Curated by ChEMBL					Assay Description Inhibition of human SIRT1				Bioorg Med Chem Lett 16: 3651-6 (2006) Article DOI: 10.1016/j.bmcl.2006.04.075 BindingDB Entry DOI: 10.7270/Q2WH2PMZ
University of Akron Curated by ChEMBL					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-2 (Homo sapiens (Human))	BDBM27507 (3-Pyridinecarboxamide \| CHEMBL1140 \| NAM \| niacina...) Show SMILES NC(=O)c1cccnc1 Show InChI	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	3.23E+4	n/a	n/a	n/a	n/a	n/a	n/a
Albert-Ludwigs-Universität Freiburg Curated by ChEMBL					Assay Description Inhibition of human recombinant SIRT2				J Med Chem 49: 7307-16 (2006) Article DOI: 10.1021/jm060118b BindingDB Entry DOI: 10.7270/Q2TQ616P
Albert-Ludwigs-Universität Freiburg Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM27507 (3-Pyridinecarboxamide \| CHEMBL1140 \| NAM \| niacina...) Show SMILES NC(=O)c1cccnc1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2.10E+5	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of PARP1 (unknown origin)				Bioorg Med Chem Lett 25: 4557-61 (2015) Article DOI: 10.1016/j.bmcl.2015.08.060 BindingDB Entry DOI: 10.7270/Q2KD20Q6
China Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM27507 (3-Pyridinecarboxamide \| CHEMBL1140 \| NAM \| niacina...) Show SMILES NC(=O)c1cccnc1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Albert-Ludwigs-University Freiburg Curated by ChEMBL					Assay Description Inhibition of human SIRT1 using MPSDKTIGG as substrate by liquid scintillation counting analysis in presence of [3H]-acetic acid				J Med Chem 59: 1599-612 (2016) Article DOI: 10.1021/acs.jmedchem.5b01517 BindingDB Entry DOI: 10.7270/Q2HX1FH2
Albert-Ludwigs-University Freiburg Curated by ChEMBL					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-2 (Homo sapiens (Human))	BDBM27507 (3-Pyridinecarboxamide \| CHEMBL1140 \| NAM \| niacina...) Show SMILES NC(=O)c1cccnc1 Show InChI	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Albert-Ludwigs-University Freiburg Curated by ChEMBL					Assay Description Inhibition of GST-tagged recombinant human SIRT2 using MPSDKTIGG as substrate by liquid scintillation counting analysis in presence of [3H]-acetic ac...				J Med Chem 59: 1599-612 (2016) Article DOI: 10.1021/acs.jmedchem.5b01517 BindingDB Entry DOI: 10.7270/Q2HX1FH2
Albert-Ludwigs-University Freiburg Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM27507 (3-Pyridinecarboxamide \| CHEMBL1140 \| NAM \| niacina...) Show SMILES NC(=O)c1cccnc1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Nagoya City University Curated by ChEMBL					Assay Description Inhibition of human recombinant SIRT1 after 60 mins by fluorimetric analysis				Bioorg Med Chem Lett 19: 5670-2 (2009) Article DOI: 10.1016/j.bmcl.2009.08.028 BindingDB Entry DOI: 10.7270/Q2WH2Q1R
Nagoya City University Curated by ChEMBL					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-2 (Homo sapiens (Human))	BDBM27507 (3-Pyridinecarboxamide \| CHEMBL1140 \| NAM \| niacina...) Show SMILES NC(=O)c1cccnc1 Show InChI	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Nagoya City University Curated by ChEMBL					Assay Description Inhibition of human recombinant SIRT2 after 60 mins by fluorimetric analysis				Bioorg Med Chem Lett 19: 5670-2 (2009) Article DOI: 10.1016/j.bmcl.2009.08.028 BindingDB Entry DOI: 10.7270/Q2WH2Q1R
Nagoya City University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
NAD-dependent protein deacetylase sirtuin-3, mitochondrial (Homo sapiens (Human))	BDBM27507 (3-Pyridinecarboxamide \| CHEMBL1140 \| NAM \| niacina...) Show SMILES NC(=O)c1cccnc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
Nagoya City University Curated by ChEMBL					Assay Description Inhibition of human recombinant SIRT3 after 60 mins by fluorimetric analysis				Bioorg Med Chem Lett 19: 5670-2 (2009) Article DOI: 10.1016/j.bmcl.2009.08.028 BindingDB Entry DOI: 10.7270/Q2WH2Q1R
Nagoya City University Curated by ChEMBL					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM27507 (3-Pyridinecarboxamide \| CHEMBL1140 \| NAM \| niacina...) Show SMILES NC(=O)c1cccnc1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2.10E+5	n/a	n/a	n/a	n/a	n/a	n/a
Johns Hopkins University Brain Science Institute Curated by ChEMBL					Assay Description Inhibition of PARP1				J Med Chem 53: 4561-84 (2010) Article DOI: 10.1021/jm100012m BindingDB Entry DOI: 10.7270/Q2NV9JF0
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM27507 (3-Pyridinecarboxamide \| CHEMBL1140 \| NAM \| niacina...) Show SMILES NC(=O)c1cccnc1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2.10E+5	n/a	n/a	n/a	n/a	n/a	n/a
Guilford Pharmaceuticals Inc Curated by ChEMBL					Assay Description Inhibitory activity against Poly (ADP-ribose) polymerase 1				J Med Chem 46: 3138-51 (2003) Article DOI: 10.1021/jm030109s BindingDB Entry DOI: 10.7270/Q2Z89D5P
Guilford Pharmaceuticals Inc Curated by ChEMBL					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM27507 (3-Pyridinecarboxamide \| CHEMBL1140 \| NAM \| niacina...) Show SMILES NC(=O)c1cccnc1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	<5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Guru Jambheshwar University of Science and Technology Curated by ChEMBL					Assay Description Non-competitive inhibition of recombinant human SIRT1 using acetylated histone as substrate measured after 30 mins by fluorimetric analysis				Eur J Med Chem 119: 45-69 (2016) Article DOI: 10.1016/j.ejmech.2016.04.063 BindingDB Entry DOI: 10.7270/Q2VH5QTW
					More data for this Ligand-Target Pair
NAD-dependent histone deacetylase SIR2 (Saccharomyces cerevisiae)	BDBM27507 (3-Pyridinecarboxamide \| CHEMBL1140 \| NAM \| niacina...) Show SMILES NC(=O)c1cccnc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	<5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Guru Jambheshwar University of Science and Technology Curated by ChEMBL					Assay Description Non-competitive inhibition of recombinant yeast glutathione-S-transferase-tagged SIRT2 using acetylated histone as substrate measured after 30 mins b...				Eur J Med Chem 119: 45-69 (2016) Article DOI: 10.1016/j.ejmech.2016.04.063 BindingDB Entry DOI: 10.7270/Q2VH5QTW
					More data for this Ligand-Target Pair				3D Structure (crystal)
NAD-dependent protein deacetylase sirtuin-2 (Homo sapiens (Human))	BDBM27507 (3-Pyridinecarboxamide \| CHEMBL1140 \| NAM \| niacina...) Show SMILES NC(=O)c1cccnc1 Show InChI	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	3.23E+4	n/a	n/a	n/a	n/a	n/a	n/a
Albert-Ludwigs-Universit£t Freiburg Curated by ChEMBL					Assay Description Inhibition of human recombinant Sirt2 expressed in Escherichia coli BL21 by fluorescent deacetylase assay				J Med Chem 51: 1203-13 (2008) Article DOI: 10.1021/jm700972e BindingDB Entry DOI: 10.7270/Q22N534Q
Albert-Ludwigs-Universit£t Freiburg Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM27507 (3-Pyridinecarboxamide \| CHEMBL1140 \| NAM \| niacina...) Show SMILES NC(=O)c1cccnc1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2.10E+5	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of PARP1 (unknown origin)				Bioorg Med Chem Lett 23: 1993-6 (2013) Article DOI: 10.1016/j.bmcl.2013.02.032 BindingDB Entry DOI: 10.7270/Q2736S9N
China Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase (Leishmania infantum)	BDBM27507 (3-Pyridinecarboxamide \| CHEMBL1140 \| NAM \| niacina...) Show SMILES NC(=O)c1cccnc1 Show InChI	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	3.94E+4	n/a	n/a	n/a	n/a	n/a	n/a
Jiangsu University Curated by ChEMBL					Assay Description Inhibition of Leishmania infantum SIR2RP1				Eur J Med Chem 59: 132-40 (2013) Article DOI: 10.1016/j.ejmech.2012.11.014 BindingDB Entry DOI: 10.7270/Q2CF9RDD
Jiangsu University Curated by ChEMBL					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM27507 (3-Pyridinecarboxamide \| CHEMBL1140 \| NAM \| niacina...) Show SMILES NC(=O)c1cccnc1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	9.04E+4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of N-terminal His6-tagged SIRT1 coding region (156-664) (unknown origin) expressed in Escherichia coli BL21(DE3) using 31.25 uM ac-RHKKac-...				Eur J Med Chem 60: 441-50 (2013) Article DOI: 10.1016/j.ejmech.2012.12.026 BindingDB Entry DOI: 10.7270/Q2WW7K0B
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM27507 (3-Pyridinecarboxamide \| CHEMBL1140 \| NAM \| niacina...) Show SMILES NC(=O)c1cccnc1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2.50E+5	n/a	n/a	n/a	n/a	n/a	n/a
Institute Curated by ChEMBL					Assay Description Inhibition of human full length SIRT1 expressed in DE3 cells by fluorimetric assay				Bioorg Med Chem 17: 7031-41 (2009) Article DOI: 10.1016/j.bmc.2009.07.073 BindingDB Entry DOI: 10.7270/Q21V5FWG
Institute Curated by ChEMBL					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase HST2 (Saccharomyces cerevisiae)	BDBM27507 (3-Pyridinecarboxamide \| CHEMBL1140 \| NAM \| niacina...) Show SMILES NC(=O)c1cccnc1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	9.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Institute Curated by ChEMBL					Assay Description Inhibition of yeast Hst2 by fluorimetric assay				Bioorg Med Chem 17: 7031-41 (2009) Article DOI: 10.1016/j.bmc.2009.07.073 BindingDB Entry DOI: 10.7270/Q21V5FWG
Institute Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM27507 (3-Pyridinecarboxamide \| CHEMBL1140 \| NAM \| niacina...) Show SMILES NC(=O)c1cccnc1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of recombinant SIRT1 using ZMAL substrate after 4 hrs by homogeneous fluorescence assay				ACS Med Chem Lett 3: 1050-1053 (2012) Article DOI: 10.1021/ml3002709 BindingDB Entry DOI: 10.7270/Q29C6ZKP
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-2 (Homo sapiens (Human))	BDBM27507 (3-Pyridinecarboxamide \| CHEMBL1140 \| NAM \| niacina...) Show SMILES NC(=O)c1cccnc1 Show InChI	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of recombinant SIRT2 using ZMAL substrate after 4 hrs by homogeneous fluorescence assay				ACS Med Chem Lett 3: 1050-1053 (2012) Article DOI: 10.1021/ml3002709 BindingDB Entry DOI: 10.7270/Q29C6ZKP
TBA Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
NAD-dependent protein deacylase sirtuin-5, mitochondrial (Homo sapiens (Human))	BDBM27507 (3-Pyridinecarboxamide \| CHEMBL1140 \| NAM \| niacina...) Show SMILES NC(=O)c1cccnc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	4.66E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of SIRT5 using ZK(suc)A substrate after 1 hr by homogeneous fluorescence assay				ACS Med Chem Lett 3: 1050-1053 (2012) Article DOI: 10.1021/ml3002709 BindingDB Entry DOI: 10.7270/Q29C6ZKP
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-3, mitochondrial (Homo sapiens (Human))	BDBM27507 (3-Pyridinecarboxamide \| CHEMBL1140 \| NAM \| niacina...) Show SMILES NC(=O)c1cccnc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of recombinant SIRT3 using ZMAL substrate after 4 hrs by homogeneous fluorescence assay				ACS Med Chem Lett 3: 1050-1053 (2012) Article DOI: 10.1021/ml3002709 BindingDB Entry DOI: 10.7270/Q29C6ZKP
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-3, mitochondrial (Homo sapiens (Human))	BDBM27507 (3-Pyridinecarboxamide \| CHEMBL1140 \| NAM \| niacina...) Show SMILES NC(=O)c1cccnc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	3.77E+5	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi del Piemonte Orientale A. Avogadro Curated by ChEMBL					Assay Description Inhibition of human SIRT3 expressed in Escherichia coli using Z-MAL as substrate after 6 hrs by fluorescence assay				Eur J Med Chem 55: 58-66 (2012) Article DOI: 10.1016/j.ejmech.2012.07.001 BindingDB Entry DOI: 10.7270/Q20K29NG
					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM27507 (3-Pyridinecarboxamide \| CHEMBL1140 \| NAM \| niacina...) Show SMILES NC(=O)c1cccnc1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	8.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
Dipartimento di Chimica e Tecnologie del Farmaco "Sapienza" Universit£ di Roma Curated by ChEMBL					Assay Description Inhibition of human SIRT1				J Med Chem 60: 4780-4804 (2017) Article DOI: 10.1021/acs.jmedchem.6b01595 BindingDB Entry DOI: 10.7270/Q2JD50D0
					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase (Leishmania infantum)	BDBM27507 (3-Pyridinecarboxamide \| CHEMBL1140 \| NAM \| niacina...) Show SMILES NC(=O)c1cccnc1 Show InChI	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Dipartimento di Chimica e Tecnologie del Farmaco "Sapienza" Universit£ di Roma Curated by ChEMBL					Assay Description Inhibition of N-terminal His6-tagged recombinant Leishmania infantum SIR2RP1 expressed in Escherichia coli in presence of NAD+ by fluorimetric method				J Med Chem 60: 4780-4804 (2017) Article DOI: 10.1021/acs.jmedchem.6b01595 BindingDB Entry DOI: 10.7270/Q2JD50D0
					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM27507 (3-Pyridinecarboxamide \| CHEMBL1140 \| NAM \| niacina...) Show SMILES NC(=O)c1cccnc1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.18E+5	n/a	n/a	n/a	n/a	n/a	n/a
Dipartimento di Chimica e Tecnologie del Farmaco "Sapienza" Universit£ di Roma Curated by ChEMBL					Assay Description Inhibition of human SIRT1 in presence of NAD+ by fluorimetric method				J Med Chem 60: 4780-4804 (2017) Article DOI: 10.1021/acs.jmedchem.6b01595 BindingDB Entry DOI: 10.7270/Q2JD50D0
					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase (Schistosoma mansoni)	BDBM27507 (3-Pyridinecarboxamide \| CHEMBL1140 \| NAM \| niacina...) Show SMILES NC(=O)c1cccnc1 Show InChI	MMDB NCI pathway Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2.31E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Freiburg Curated by ChEMBL					Assay Description Inhibition of recombinant Schistosoma mansoni sirtuin 2 (21 to 322 residues) expressed in Escherichia coli BL21(DE3) cells assessed as inhibition of ...				J Med Chem 62: 8733-8759 (2019) Article DOI: 10.1021/acs.jmedchem.9b00638 BindingDB Entry DOI: 10.7270/Q25142HK
University of Freiburg Curated by ChEMBL					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-2 (Homo sapiens (Human))	BDBM27507 (3-Pyridinecarboxamide \| CHEMBL1140 \| NAM \| niacina...) Show SMILES NC(=O)c1cccnc1 Show InChI	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	4.98E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Freiburg Curated by ChEMBL					Assay Description Inhibition of human sirtuin 2 assessed as inhibition of substrate deacetylation using ZMAL as substrate				J Med Chem 62: 8733-8759 (2019) Article DOI: 10.1021/acs.jmedchem.9b00638 BindingDB Entry DOI: 10.7270/Q25142HK
University of Freiburg Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
NAD-dependent protein deacetylase sirtuin-2 (Homo sapiens (Human))	BDBM27507 (3-Pyridinecarboxamide \| CHEMBL1140 \| NAM \| niacina...) Show SMILES NC(=O)c1cccnc1 Show InChI	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	3.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
Nagoya City University Curated by ChEMBL					Assay Description Inhibition of recombinant human SIRT2 deacylation activity using Fluor de Lys Sirt2 as substrate measured at 5 mins interval for 30 mins in presence ...				J Med Chem 62: 5434-5452 (2019) Article DOI: 10.1021/acs.jmedchem.9b00315 BindingDB Entry DOI: 10.7270/Q2HH6P91
Nagoya City University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human))	BDBM27507 (3-Pyridinecarboxamide \| CHEMBL1140 \| NAM \| niacina...) Show SMILES NC(=O)c1cccnc1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	3.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
Nagoya City University Curated by ChEMBL					Assay Description Inhibition of recombinant human C-terminal His6-tagged SIRT1 (Met1 to Ser747 residues) defatty-acylase activity expressed in Escherichia coli using S...				J Med Chem 62: 5434-5452 (2019) Article DOI: 10.1021/acs.jmedchem.9b00315 BindingDB Entry DOI: 10.7270/Q2HH6P91
Nagoya City University Curated by ChEMBL					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-3, mitochondrial (Homo sapiens (Human))	BDBM27507 (3-Pyridinecarboxamide \| CHEMBL1140 \| NAM \| niacina...) Show SMILES NC(=O)c1cccnc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Nagoya City University Curated by ChEMBL					Assay Description Inhibition of recombinant human SIRT3 (118 to 399 residues) defatty-acylase activity expressed in Escherichia coli using SFP3 as substrate measured a...				J Med Chem 62: 5434-5452 (2019) Article DOI: 10.1021/acs.jmedchem.9b00315 BindingDB Entry DOI: 10.7270/Q2HH6P91
Nagoya City University Curated by ChEMBL					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-2 (Homo sapiens (Human))	BDBM27507 (3-Pyridinecarboxamide \| CHEMBL1140 \| NAM \| niacina...) Show SMILES NC(=O)c1cccnc1 Show InChI	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Nagoya City University Curated by ChEMBL					Assay Description Inhibition of recombinant human SIRT2 defatty-acylase activity using SFP3 as substrate measured at 5 mins interval for 60 mins in presence of NAD+ by...				J Med Chem 62: 5434-5452 (2019) Article DOI: 10.1021/acs.jmedchem.9b00315 BindingDB Entry DOI: 10.7270/Q2HH6P91
Nagoya City University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
NAD-dependent protein deacylase sirtuin-6 (Homo sapiens (Human))	BDBM27507 (3-Pyridinecarboxamide \| CHEMBL1140 \| NAM \| niacina...) Show SMILES NC(=O)c1cccnc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	1.20E+5	n/a	n/a	n/a	n/a	n/a	n/a
Nagoya City University Curated by ChEMBL					Assay Description Inhibition of recombinant human N-terminal polyhis-tagged SIRT6 (1 to 355 residues) defatty-acylase activity expressed in Escherichia coli using SFP3...				J Med Chem 62: 5434-5452 (2019) Article DOI: 10.1021/acs.jmedchem.9b00315 BindingDB Entry DOI: 10.7270/Q2HH6P91
Nagoya City University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
NAD-dependent protein deacetylase sirtuin-2 (Homo sapiens (Human))	BDBM27507 (3-Pyridinecarboxamide \| CHEMBL1140 \| NAM \| niacina...) Show SMILES NC(=O)c1cccnc1 Show InChI	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Nagoya City University Curated by ChEMBL					Assay Description Inhibition of recombinant human SIRT2 demyristoylase activity using p53(Myr)-AMC as substrate measured after 3 hrs in presence of NAD+ and trypsin by...				J Med Chem 62: 5434-5452 (2019) Article DOI: 10.1021/acs.jmedchem.9b00315 BindingDB Entry DOI: 10.7270/Q2HH6P91
Nagoya City University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
NAD-dependent protein deacetylase (Schistosoma mansoni)	BDBM27507 (3-Pyridinecarboxamide \| CHEMBL1140 \| NAM \| niacina...) Show SMILES NC(=O)c1cccnc1 Show InChI	MMDB NCI pathway Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	4.20E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Freiburg Curated by ChEMBL					Assay Description Inhibition of recombinant Schistosoma mansoni sirtuin 2 (21 to 322 residues) expressed in Escherichia coli BL21(DE3) cells assessed as inhibition of ...				J Med Chem 62: 8733-8759 (2019) Article DOI: 10.1021/acs.jmedchem.9b00638 BindingDB Entry DOI: 10.7270/Q25142HK
University of Freiburg Curated by ChEMBL					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-3, mitochondrial (Homo sapiens (Human))	BDBM27507 (3-Pyridinecarboxamide \| CHEMBL1140 \| NAM \| niacina...) Show SMILES NC(=O)c1cccnc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	7.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of human SIRT3 assessed as reduction in deacetylase activity using acetylated H3K9 as substrate preincubated for 15 mins followed by subst...				J Med Chem 62: 4131-4141 (2019) Article DOI: 10.1021/acs.jmedchem.9b00191 BindingDB Entry DOI: 10.7270/Q21C21BC
TBA Curated by ChEMBL					More data for this Ligand-Target Pair

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