BDBM2759 1-Bromo-4,4-bis[8,8-dichloro-2,2,2,2-tetramethyl-4,4-dioxo-6,6-(1,3-benzodioxyl)]-3-butene::6-[4-bromo-1-(8-chloro-2,2-dimethyl-4-oxo-2,4-dihydro-1,3-benzodioxin-6-yl)but-1-en-1-yl]-8-chloro-2,2-dimethyl-2,4-dihydro-1,3-benzodioxin-4-one::Alkenyldiarylmethane (ADAM) 35::Alkenyldiarylmethanes (ADAM) 35
SMILES: [#6]C1([#6])[#8]-[#6](=O)-c2cc(cc(Cl)c2-[#8]1)-[#6](=[#6]/[#6]-[#6]Br)\c1cc(Cl)c2-[#8]C([#6])([#6])[#8]-[#6](=O)-c2c1
InChI Key: InChIKey=XJMUIRCKKLBSBS-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
HIV-1 Reverse Transcriptase (Human immunodeficiency virus type 1) | BDBM2759 (1-Bromo-4,4-bis[8,8-dichloro-2,2,2,2-tetramethyl-4...) | PDB MMDB B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | 7.9 | n/a |
Purdue University | Assay Description The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro. | J Med Chem 41: 2076-89 (1998) Article DOI: 10.1021/jm9800595 BindingDB Entry DOI: 10.7270/Q2251GC2 | |||||||||||
More data for this Ligand-Target Pair |