BDBM275908 US10071974, Example 19::US10577336, Example 19

SMILES: Cn1nc(c2ccccc12)C(C)(C)NC(=O)[C@@H]1CNCCO1

InChI Key: InChIKey=WHNDJETXLOREIT-ZDUSSCGKSA-N

Data: 10 KI  2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 275908   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Somatostatin receptor type 4 (Homo sapiens (Human))	BDBM275908 (US10071974, Example 19 | US10577336, Example 19) Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)[C@@H]1CNCCO1 |r| Show InChI InChI=1S/C16H22N4O2/c1-16(2,18-15(21)13-10-17-8-9-22-13)14-11-6-4-5-7-12(11)20(3)19-14/h4-7,13,17H,8-10H2,1-3H3,(H,18,21)/t13-/m0/s1	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	194	-9.15	n/a	n/a	n/a	n/a	n/a	n/a	25
Boehringer Ingelheim International GmbH US Patent					Assay Description For the binding experiments 200 μL of membrane homogenate from one of the following protein amounts is used: hSSTR1 (40 μg/well); hSSTR2 (2...				US Patent US10071974 (2018) BindingDB Entry DOI: 10.7270/Q28G8NQ7
					More data for this Ligand-Target Pair
Somatostatin receptor type 4 (Homo sapiens (Human))	BDBM275908 (US10071974, Example 19 | US10577336, Example 19) Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)[C@@H]1CNCCO1 |r| Show InChI InChI=1S/C16H22N4O2/c1-16(2,18-15(21)13-10-17-8-9-22-13)14-11-6-4-5-7-12(11)20(3)19-14/h4-7,13,17H,8-10H2,1-3H3,(H,18,21)/t13-/m0/s1	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	194	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description Receptor binding assays refer to a technique in which labeled receptor ligands are used to detect binding to a receptor. In competition experiments t...				US Patent US10577336 (2020) BindingDB Entry DOI: 10.7270/Q24F1T4F
					More data for this Ligand-Target Pair
Somatostatin receptor type 3 (Homo sapiens (Human))	BDBM275908 (US10071974, Example 19 | US10577336, Example 19) Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)[C@@H]1CNCCO1 |r| Show InChI InChI=1S/C16H22N4O2/c1-16(2,18-15(21)13-10-17-8-9-22-13)14-11-6-4-5-7-12(11)20(3)19-14/h4-7,13,17H,8-10H2,1-3H3,(H,18,21)/t13-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	8.71E+3	-6.90	n/a	n/a	n/a	n/a	n/a	n/a	25
Boehringer Ingelheim International GmbH US Patent					Assay Description For the binding experiments 200 μL of membrane homogenate from one of the following protein amounts is used: hSSTR1 (40 μg/well); hSSTR2 (2...				US Patent US10071974 (2018) BindingDB Entry DOI: 10.7270/Q28G8NQ7
					More data for this Ligand-Target Pair
Somatostatin receptor type 3 (Homo sapiens (Human))	BDBM275908 (US10071974, Example 19 | US10577336, Example 19) Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)[C@@H]1CNCCO1 |r| Show InChI InChI=1S/C16H22N4O2/c1-16(2,18-15(21)13-10-17-8-9-22-13)14-11-6-4-5-7-12(11)20(3)19-14/h4-7,13,17H,8-10H2,1-3H3,(H,18,21)/t13-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	8.71E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description Receptor binding assays refer to a technique in which labeled receptor ligands are used to detect binding to a receptor. In competition experiments t...				US Patent US10577336 (2020) BindingDB Entry DOI: 10.7270/Q24F1T4F
					More data for this Ligand-Target Pair
Somatostatin receptor type 1 (Homo sapiens (Human))	BDBM275908 (US10071974, Example 19 | US10577336, Example 19) Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)[C@@H]1CNCCO1 |r| Show InChI InChI=1S/C16H22N4O2/c1-16(2,18-15(21)13-10-17-8-9-22-13)14-11-6-4-5-7-12(11)20(3)19-14/h4-7,13,17H,8-10H2,1-3H3,(H,18,21)/t13-/m0/s1	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	9.01E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description Receptor binding assays refer to a technique in which labeled receptor ligands are used to detect binding to a receptor. In competition experiments t...				US Patent US10577336 (2020) BindingDB Entry DOI: 10.7270/Q24F1T4F
					More data for this Ligand-Target Pair
Somatostatin receptor type 1 (Homo sapiens (Human))	BDBM275908 (US10071974, Example 19 | US10577336, Example 19) Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)[C@@H]1CNCCO1 |r| Show InChI InChI=1S/C16H22N4O2/c1-16(2,18-15(21)13-10-17-8-9-22-13)14-11-6-4-5-7-12(11)20(3)19-14/h4-7,13,17H,8-10H2,1-3H3,(H,18,21)/t13-/m0/s1	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	9.01E+3	-6.88	n/a	n/a	n/a	n/a	n/a	n/a	25
Boehringer Ingelheim International GmbH US Patent					Assay Description For the binding experiments 200 μL of membrane homogenate from one of the following protein amounts is used: hSSTR1 (40 μg/well); hSSTR2 (2...				US Patent US10071974 (2018) BindingDB Entry DOI: 10.7270/Q28G8NQ7
					More data for this Ligand-Target Pair
Somatostatin receptor type 2 (Homo sapiens (Human))	BDBM275908 (US10071974, Example 19 | US10577336, Example 19) Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)[C@@H]1CNCCO1 |r| Show InChI InChI=1S/C16H22N4O2/c1-16(2,18-15(21)13-10-17-8-9-22-13)14-11-6-4-5-7-12(11)20(3)19-14/h4-7,13,17H,8-10H2,1-3H3,(H,18,21)/t13-/m0/s1	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	9.63E+3	-6.84	n/a	n/a	n/a	n/a	n/a	n/a	25
Boehringer Ingelheim International GmbH US Patent					Assay Description For the binding experiments 200 μL of membrane homogenate from one of the following protein amounts is used: hSSTR1 (40 μg/well); hSSTR2 (2...				US Patent US10071974 (2018) BindingDB Entry DOI: 10.7270/Q28G8NQ7
					More data for this Ligand-Target Pair
Somatostatin receptor type 2 (Homo sapiens (Human))	BDBM275908 (US10071974, Example 19 | US10577336, Example 19) Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)[C@@H]1CNCCO1 |r| Show InChI InChI=1S/C16H22N4O2/c1-16(2,18-15(21)13-10-17-8-9-22-13)14-11-6-4-5-7-12(11)20(3)19-14/h4-7,13,17H,8-10H2,1-3H3,(H,18,21)/t13-/m0/s1	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	9.63E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description Receptor binding assays refer to a technique in which labeled receptor ligands are used to detect binding to a receptor. In competition experiments t...				US Patent US10577336 (2020) BindingDB Entry DOI: 10.7270/Q24F1T4F
					More data for this Ligand-Target Pair
Somatostatin receptor type 5 (Homo sapiens (Human))	BDBM275908 (US10071974, Example 19 | US10577336, Example 19) Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)[C@@H]1CNCCO1 |r| Show InChI InChI=1S/C16H22N4O2/c1-16(2,18-15(21)13-10-17-8-9-22-13)14-11-6-4-5-7-12(11)20(3)19-14/h4-7,13,17H,8-10H2,1-3H3,(H,18,21)/t13-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	9.86E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description Receptor binding assays refer to a technique in which labeled receptor ligands are used to detect binding to a receptor. In competition experiments t...				US Patent US10577336 (2020) BindingDB Entry DOI: 10.7270/Q24F1T4F
					More data for this Ligand-Target Pair
Somatostatin receptor type 5 (Homo sapiens (Human))	BDBM275908 (US10071974, Example 19 | US10577336, Example 19) Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)[C@@H]1CNCCO1 |r| Show InChI InChI=1S/C16H22N4O2/c1-16(2,18-15(21)13-10-17-8-9-22-13)14-11-6-4-5-7-12(11)20(3)19-14/h4-7,13,17H,8-10H2,1-3H3,(H,18,21)/t13-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	9.86E+3	-6.82	n/a	n/a	n/a	n/a	n/a	n/a	25
Boehringer Ingelheim International GmbH US Patent					Assay Description For the binding experiments 200 μL of membrane homogenate from one of the following protein amounts is used: hSSTR1 (40 μg/well); hSSTR2 (2...				US Patent US10071974 (2018) BindingDB Entry DOI: 10.7270/Q28G8NQ7
					More data for this Ligand-Target Pair
Somatostatin receptor type 4 (Homo sapiens (Human))	BDBM275908 (US10071974, Example 19 | US10577336, Example 19) Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)[C@@H]1CNCCO1 |r| Show InChI InChI=1S/C16H22N4O2/c1-16(2,18-15(21)13-10-17-8-9-22-13)14-11-6-4-5-7-12(11)20(3)19-14/h4-7,13,17H,8-10H2,1-3H3,(H,18,21)/t13-/m0/s1	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	13.3	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...				US Patent US10577336 (2020) BindingDB Entry DOI: 10.7270/Q24F1T4F
					More data for this Ligand-Target Pair
Somatostatin receptor type 4 (Homo sapiens (Human))	BDBM275908 (US10071974, Example 19 | US10577336, Example 19) Show SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)[C@@H]1CNCCO1 |r| Show InChI InChI=1S/C16H22N4O2/c1-16(2,18-15(21)13-10-17-8-9-22-13)14-11-6-4-5-7-12(11)20(3)19-14/h4-7,13,17H,8-10H2,1-3H3,(H,18,21)/t13-/m0/s1	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	13.3	n/a	n/a	7.4	25
Boehringer Ingelheim International GmbH US Patent					Assay Description Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026...				US Patent US10071974 (2018) BindingDB Entry DOI: 10.7270/Q28G8NQ7
					More data for this Ligand-Target Pair