BDBM275909 US10071974, Example 20::US10071974, Example 21::US10071974, Example 22::US10577336, Example 22
SMILES: Cn1nc(c2ccccc12)C(C)(C)NC(=O)C1CNCCOC1
InChI Key: InChIKey=IRHDWZLZUPTXTM-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Somatostatin receptor type 4 (Homo sapiens (Human)) | BDBM275909 (US10071974, Example 20 | US10071974, Example 21 | ...) | KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 89.2 | -9.61 | n/a | n/a | n/a | n/a | n/a | n/a | 25 |
Boehringer Ingelheim International GmbH US Patent | Assay Description For the binding experiments 200 μL of membrane homogenate from one of the following protein amounts is used: hSSTR1 (40 μg/well); hSSTR2 (2... | US Patent US10071974 (2018) BindingDB Entry DOI: 10.7270/Q28G8NQ7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Somatostatin receptor type 4 (Homo sapiens (Human)) | BDBM275909 (US10071974, Example 20 | US10071974, Example 21 | ...) | KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 89.2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim International GmbH US Patent | Assay Description Receptor binding assays refer to a technique in which labeled receptor ligands are used to detect binding to a receptor. In competition experiments t... | US Patent US10577336 (2020) BindingDB Entry DOI: 10.7270/Q24F1T4F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Somatostatin receptor type 3 (Homo sapiens (Human)) | BDBM275909 (US10071974, Example 20 | US10071974, Example 21 | ...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 8.62E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim International GmbH US Patent | Assay Description Receptor binding assays refer to a technique in which labeled receptor ligands are used to detect binding to a receptor. In competition experiments t... | US Patent US10577336 (2020) BindingDB Entry DOI: 10.7270/Q24F1T4F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Somatostatin receptor type 3 (Homo sapiens (Human)) | BDBM275909 (US10071974, Example 20 | US10071974, Example 21 | ...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 8.62E+3 | -6.90 | n/a | n/a | n/a | n/a | n/a | n/a | 25 |
Boehringer Ingelheim International GmbH US Patent | Assay Description For the binding experiments 200 μL of membrane homogenate from one of the following protein amounts is used: hSSTR1 (40 μg/well); hSSTR2 (2... | US Patent US10071974 (2018) BindingDB Entry DOI: 10.7270/Q28G8NQ7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Somatostatin receptor type 1 (Homo sapiens (Human)) | BDBM275909 (US10071974, Example 20 | US10071974, Example 21 | ...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 9.45E+3 | -6.85 | n/a | n/a | n/a | n/a | n/a | n/a | 25 |
Boehringer Ingelheim International GmbH US Patent | Assay Description For the binding experiments 200 μL of membrane homogenate from one of the following protein amounts is used: hSSTR1 (40 μg/well); hSSTR2 (2... | US Patent US10071974 (2018) BindingDB Entry DOI: 10.7270/Q28G8NQ7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Somatostatin receptor type 1 (Homo sapiens (Human)) | BDBM275909 (US10071974, Example 20 | US10071974, Example 21 | ...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 9.45E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim International GmbH US Patent | Assay Description Receptor binding assays refer to a technique in which labeled receptor ligands are used to detect binding to a receptor. In competition experiments t... | US Patent US10577336 (2020) BindingDB Entry DOI: 10.7270/Q24F1T4F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Somatostatin receptor type 2 (Homo sapiens (Human)) | BDBM275909 (US10071974, Example 20 | US10071974, Example 21 | ...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 9.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim International GmbH US Patent | Assay Description Receptor binding assays refer to a technique in which labeled receptor ligands are used to detect binding to a receptor. In competition experiments t... | US Patent US10577336 (2020) BindingDB Entry DOI: 10.7270/Q24F1T4F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Somatostatin receptor type 2 (Homo sapiens (Human)) | BDBM275909 (US10071974, Example 20 | US10071974, Example 21 | ...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 9.60E+3 | -6.84 | n/a | n/a | n/a | n/a | n/a | n/a | 25 |
Boehringer Ingelheim International GmbH US Patent | Assay Description For the binding experiments 200 μL of membrane homogenate from one of the following protein amounts is used: hSSTR1 (40 μg/well); hSSTR2 (2... | US Patent US10071974 (2018) BindingDB Entry DOI: 10.7270/Q28G8NQ7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Somatostatin receptor type 5 (Homo sapiens (Human)) | BDBM275909 (US10071974, Example 20 | US10071974, Example 21 | ...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 9.75E+3 | -6.83 | n/a | n/a | n/a | n/a | n/a | n/a | 25 |
Boehringer Ingelheim International GmbH US Patent | Assay Description For the binding experiments 200 μL of membrane homogenate from one of the following protein amounts is used: hSSTR1 (40 μg/well); hSSTR2 (2... | US Patent US10071974 (2018) BindingDB Entry DOI: 10.7270/Q28G8NQ7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Somatostatin receptor type 5 (Homo sapiens (Human)) | BDBM275909 (US10071974, Example 20 | US10071974, Example 21 | ...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 9.75E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim International GmbH US Patent | Assay Description Receptor binding assays refer to a technique in which labeled receptor ligands are used to detect binding to a receptor. In competition experiments t... | US Patent US10577336 (2020) BindingDB Entry DOI: 10.7270/Q24F1T4F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Somatostatin receptor type 4 (Homo sapiens (Human)) | BDBM275909 (US10071974, Example 20 | US10071974, Example 21 | ...) | KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 3.90 | n/a | n/a | 7.4 | 25 |
Boehringer Ingelheim International GmbH US Patent | Assay Description Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026... | US Patent US10071974 (2018) BindingDB Entry DOI: 10.7270/Q28G8NQ7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Somatostatin receptor type 4 (Homo sapiens (Human)) | BDBM275909 (US10071974, Example 20 | US10071974, Example 21 | ...) | KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 3.20 | n/a | n/a | n/a | n/a |
Boehringer Ingelheim International GmbH US Patent | Assay Description The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia... | US Patent US10577336 (2020) BindingDB Entry DOI: 10.7270/Q24F1T4F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Somatostatin receptor type 4 (Homo sapiens (Human)) | BDBM275909 (US10071974, Example 20 | US10071974, Example 21 | ...) | KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 3.90 | n/a | n/a | n/a | n/a |
Boehringer Ingelheim International GmbH US Patent | Assay Description The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia... | US Patent US10577336 (2020) BindingDB Entry DOI: 10.7270/Q24F1T4F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Somatostatin receptor type 4 (Homo sapiens (Human)) | BDBM275909 (US10071974, Example 20 | US10071974, Example 21 | ...) | KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 192 | n/a | n/a | 7.4 | 25 |
Boehringer Ingelheim International GmbH US Patent | Assay Description Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026... | US Patent US10071974 (2018) BindingDB Entry DOI: 10.7270/Q28G8NQ7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Somatostatin receptor type 4 (Homo sapiens (Human)) | BDBM275909 (US10071974, Example 20 | US10071974, Example 21 | ...) | KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 3.20 | n/a | n/a | 7.4 | 25 |
Boehringer Ingelheim International GmbH US Patent | Assay Description Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026... | US Patent US10071974 (2018) BindingDB Entry DOI: 10.7270/Q28G8NQ7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Somatostatin receptor type 4 (Homo sapiens (Human)) | BDBM275909 (US10071974, Example 20 | US10071974, Example 21 | ...) | KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 192 | n/a | n/a | n/a | n/a |
Boehringer Ingelheim International GmbH US Patent | Assay Description The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia... | US Patent US10577336 (2020) BindingDB Entry DOI: 10.7270/Q24F1T4F | |||||||||||
More data for this Ligand-Target Pair |