BDBM275912 US10071974, Example 23::US10071974, Example 24::US10071974, Example 25::US10577336, Example 25
SMILES: Cn1nc(c2ccccc12)C(C)(C)NC(=O)C1CNCCCO1
InChI Key: InChIKey=GWOJVVDZCRLEDR-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Somatostatin receptor type 4 (Homo sapiens (Human)) | BDBM275912 (US10071974, Example 23 | US10071974, Example 24 | ...) | KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 522 | -8.56 | n/a | n/a | n/a | n/a | n/a | n/a | 25 |
Boehringer Ingelheim International GmbH US Patent | Assay Description For the binding experiments 200 μL of membrane homogenate from one of the following protein amounts is used: hSSTR1 (40 μg/well); hSSTR2 (2... | US Patent US10071974 (2018) BindingDB Entry DOI: 10.7270/Q28G8NQ7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Somatostatin receptor type 4 (Homo sapiens (Human)) | BDBM275912 (US10071974, Example 23 | US10071974, Example 24 | ...) | KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 522 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim International GmbH US Patent | Assay Description Receptor binding assays refer to a technique in which labeled receptor ligands are used to detect binding to a receptor. In competition experiments t... | US Patent US10577336 (2020) BindingDB Entry DOI: 10.7270/Q24F1T4F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Somatostatin receptor type 3 (Homo sapiens (Human)) | BDBM275912 (US10071974, Example 23 | US10071974, Example 24 | ...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 8.62E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim International GmbH US Patent | Assay Description Receptor binding assays refer to a technique in which labeled receptor ligands are used to detect binding to a receptor. In competition experiments t... | US Patent US10577336 (2020) BindingDB Entry DOI: 10.7270/Q24F1T4F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Somatostatin receptor type 3 (Homo sapiens (Human)) | BDBM275912 (US10071974, Example 23 | US10071974, Example 24 | ...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 8.62E+3 | -6.90 | n/a | n/a | n/a | n/a | n/a | n/a | 25 |
Boehringer Ingelheim International GmbH US Patent | Assay Description For the binding experiments 200 μL of membrane homogenate from one of the following protein amounts is used: hSSTR1 (40 μg/well); hSSTR2 (2... | US Patent US10071974 (2018) BindingDB Entry DOI: 10.7270/Q28G8NQ7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Somatostatin receptor type 1 (Homo sapiens (Human)) | BDBM275912 (US10071974, Example 23 | US10071974, Example 24 | ...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 9.45E+3 | -6.85 | n/a | n/a | n/a | n/a | n/a | n/a | 25 |
Boehringer Ingelheim International GmbH US Patent | Assay Description For the binding experiments 200 μL of membrane homogenate from one of the following protein amounts is used: hSSTR1 (40 μg/well); hSSTR2 (2... | US Patent US10071974 (2018) BindingDB Entry DOI: 10.7270/Q28G8NQ7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Somatostatin receptor type 1 (Homo sapiens (Human)) | BDBM275912 (US10071974, Example 23 | US10071974, Example 24 | ...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 9.45E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim International GmbH US Patent | Assay Description Receptor binding assays refer to a technique in which labeled receptor ligands are used to detect binding to a receptor. In competition experiments t... | US Patent US10577336 (2020) BindingDB Entry DOI: 10.7270/Q24F1T4F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Somatostatin receptor type 2 (Homo sapiens (Human)) | BDBM275912 (US10071974, Example 23 | US10071974, Example 24 | ...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 9.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim International GmbH US Patent | Assay Description Receptor binding assays refer to a technique in which labeled receptor ligands are used to detect binding to a receptor. In competition experiments t... | US Patent US10577336 (2020) BindingDB Entry DOI: 10.7270/Q24F1T4F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Somatostatin receptor type 2 (Homo sapiens (Human)) | BDBM275912 (US10071974, Example 23 | US10071974, Example 24 | ...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 9.60E+3 | -6.84 | n/a | n/a | n/a | n/a | n/a | n/a | 25 |
Boehringer Ingelheim International GmbH US Patent | Assay Description For the binding experiments 200 μL of membrane homogenate from one of the following protein amounts is used: hSSTR1 (40 μg/well); hSSTR2 (2... | US Patent US10071974 (2018) BindingDB Entry DOI: 10.7270/Q28G8NQ7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Somatostatin receptor type 5 (Homo sapiens (Human)) | BDBM275912 (US10071974, Example 23 | US10071974, Example 24 | ...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 9.75E+3 | -6.83 | n/a | n/a | n/a | n/a | n/a | n/a | 25 |
Boehringer Ingelheim International GmbH US Patent | Assay Description For the binding experiments 200 μL of membrane homogenate from one of the following protein amounts is used: hSSTR1 (40 μg/well); hSSTR2 (2... | US Patent US10071974 (2018) BindingDB Entry DOI: 10.7270/Q28G8NQ7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Somatostatin receptor type 5 (Homo sapiens (Human)) | BDBM275912 (US10071974, Example 23 | US10071974, Example 24 | ...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 9.75E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim International GmbH US Patent | Assay Description Receptor binding assays refer to a technique in which labeled receptor ligands are used to detect binding to a receptor. In competition experiments t... | US Patent US10577336 (2020) BindingDB Entry DOI: 10.7270/Q24F1T4F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Somatostatin receptor type 4 (Homo sapiens (Human)) | BDBM275912 (US10071974, Example 23 | US10071974, Example 24 | ...) | KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 36.5 | n/a | n/a | 7.4 | 25 |
Boehringer Ingelheim International GmbH US Patent | Assay Description Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026... | US Patent US10071974 (2018) BindingDB Entry DOI: 10.7270/Q28G8NQ7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Somatostatin receptor type 4 (Homo sapiens (Human)) | BDBM275912 (US10071974, Example 23 | US10071974, Example 24 | ...) | KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 36.2 | n/a | n/a | n/a | n/a |
Boehringer Ingelheim International GmbH US Patent | Assay Description The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia... | US Patent US10577336 (2020) BindingDB Entry DOI: 10.7270/Q24F1T4F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Somatostatin receptor type 4 (Homo sapiens (Human)) | BDBM275912 (US10071974, Example 23 | US10071974, Example 24 | ...) | KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 36.5 | n/a | n/a | n/a | n/a |
Boehringer Ingelheim International GmbH US Patent | Assay Description The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia... | US Patent US10577336 (2020) BindingDB Entry DOI: 10.7270/Q24F1T4F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Somatostatin receptor type 4 (Homo sapiens (Human)) | BDBM275912 (US10071974, Example 23 | US10071974, Example 24 | ...) | KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 1.00E+3 | n/a | n/a | 7.4 | 25 |
Boehringer Ingelheim International GmbH US Patent | Assay Description Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026... | US Patent US10071974 (2018) BindingDB Entry DOI: 10.7270/Q28G8NQ7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Somatostatin receptor type 4 (Homo sapiens (Human)) | BDBM275912 (US10071974, Example 23 | US10071974, Example 24 | ...) | KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 36.2 | n/a | n/a | 7.4 | 25 |
Boehringer Ingelheim International GmbH US Patent | Assay Description Compounds are dissolved and diluted in DMSO. The final test solution contains 1% DMSO. The cAMP standard (Lance cAMP 384 Kit; PerkinElmer, Cat# AD026... | US Patent US10071974 (2018) BindingDB Entry DOI: 10.7270/Q28G8NQ7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Somatostatin receptor type 4 (Homo sapiens (Human)) | BDBM275912 (US10071974, Example 23 | US10071974, Example 24 | ...) | KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a |
Boehringer Ingelheim International GmbH US Patent | Assay Description The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia... | US Patent US10577336 (2020) BindingDB Entry DOI: 10.7270/Q24F1T4F | |||||||||||
More data for this Ligand-Target Pair |