BDBM276044 2-[1-[2-(2-chlorophenyl)ethyl]imidazol-4-yl]-4-(1H-triazol-4-yl)pyridine::US10071984, Example 6::US10174003, Example 6::US9896436, Example 6

SMILES: Clc1ccccc1CCn1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1

InChI Key: InChIKey=SSFFXSKRQXVLOJ-UHFFFAOYSA-N

Data: 9 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 276044   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM276044 (2-[1-[2-(2-chlorophenyl)ethyl]imidazol-4-yl]-4-(1H...) Show SMILES Clc1ccccc1CCn1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1 Show InChI InChI=1S/C18H15ClN6/c19-15-4-2-1-3-13(15)6-8-25-11-18(21-12-25)16-9-14(5-7-20-16)17-10-22-24-23-17/h1-5,7,9-12H,6,8H2,(H,22,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	25
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...				US Patent US10071984 (2018) BindingDB Entry DOI: 10.7270/Q24Q7X0X
					More data for this Ligand-Target Pair
Homo sapiens lysine demethylase 2A (KDM2A) (Homo sapiens (Human))	BDBM276044 (2-[1-[2-(2-chlorophenyl)ethyl]imidazol-4-yl]-4-(1H...) Show SMILES Clc1ccccc1CCn1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1 Show InChI InChI=1S/C18H15ClN6/c19-15-4-2-1-3-13(15)6-8-25-11-18(21-12-25)16-9-14(5-7-20-16)17-10-22-24-23-17/h1-5,7,9-12H,6,8H2,(H,22,23,24)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	25
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of FBXL11 was determined in 384-well plate format under the following reaction conditions: 0.15...				US Patent US10071984 (2018) BindingDB Entry DOI: 10.7270/Q24Q7X0X
					More data for this Ligand-Target Pair
histone lysine demethylase PHF8 isoform 2 (Homo sapiens (Human))	BDBM276044 (2-[1-[2-(2-chlorophenyl)ethyl]imidazol-4-yl]-4-(1H...) Show SMILES Clc1ccccc1CCn1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1 Show InChI InChI=1S/C18H15ClN6/c19-15-4-2-1-3-13(15)6-8-25-11-18(21-12-25)16-9-14(5-7-20-16)17-10-22-24-23-17/h1-5,7,9-12H,6,8H2,(H,22,23,24)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	25
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction conditions: 3 nM P...				US Patent US10071984 (2018) BindingDB Entry DOI: 10.7270/Q24Q7X0X
					More data for this Ligand-Target Pair
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM276044 (2-[1-[2-(2-chlorophenyl)ethyl]imidazol-4-yl]-4-(1H...) Show SMILES Clc1ccccc1CCn1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1 Show InChI InChI=1S/C18H15ClN6/c19-15-4-2-1-3-13(15)6-8-25-11-18(21-12-25)16-9-14(5-7-20-16)17-10-22-24-23-17/h1-5,7,9-12H,6,8H2,(H,22,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...				US Patent US10174003 (2019) BindingDB Entry DOI: 10.7270/Q2417053
					More data for this Ligand-Target Pair
Histone lysine demethylase PHF8 (Homo sapiens (Human))	BDBM276044 (2-[1-[2-(2-chlorophenyl)ethyl]imidazol-4-yl]-4-(1H...) Show SMILES Clc1ccccc1CCn1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1 Show InChI InChI=1S/C18H15ClN6/c19-15-4-2-1-3-13(15)6-8-25-11-18(21-12-25)16-9-14(5-7-20-16)17-10-22-24-23-17/h1-5,7,9-12H,6,8H2,(H,22,23,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description PHF8 Assay: The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction condit...				Bioorg Med Chem Lett 17: 1584-9 (2007) BindingDB Entry DOI: 10.7270/Q2FT8PBQ
					More data for this Ligand-Target Pair
Histone lysine demethylase PHF8 (Homo sapiens (Human))	BDBM276044 (2-[1-[2-(2-chlorophenyl)ethyl]imidazol-4-yl]-4-(1H...) Show SMILES Clc1ccccc1CCn1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1 Show InChI InChI=1S/C18H15ClN6/c19-15-4-2-1-3-13(15)6-8-25-11-18(21-12-25)16-9-14(5-7-20-16)17-10-22-24-23-17/h1-5,7,9-12H,6,8H2,(H,22,23,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction conditions: 3 nM P...				US Patent US10174003 (2019) BindingDB Entry DOI: 10.7270/Q2417053
					More data for this Ligand-Target Pair
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM276044 (2-[1-[2-(2-chlorophenyl)ethyl]imidazol-4-yl]-4-(1H...) Show SMILES Clc1ccccc1CCn1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1 Show InChI InChI=1S/C18H15ClN6/c19-15-4-2-1-3-13(15)6-8-25-11-18(21-12-25)16-9-14(5-7-20-16)17-10-22-24-23-17/h1-5,7,9-12H,6,8H2,(H,22,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...				Bioorg Med Chem Lett 17: 1584-9 (2007) BindingDB Entry DOI: 10.7270/Q2FT8PBQ
					More data for this Ligand-Target Pair
Homo sapiens lysine demethylase 2A (KDM2A) (Homo sapiens (Human))	BDBM276044 (2-[1-[2-(2-chlorophenyl)ethyl]imidazol-4-yl]-4-(1H...) Show SMILES Clc1ccccc1CCn1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1 Show InChI InChI=1S/C18H15ClN6/c19-15-4-2-1-3-13(15)6-8-25-11-18(21-12-25)16-9-14(5-7-20-16)17-10-22-24-23-17/h1-5,7,9-12H,6,8H2,(H,22,23,24)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description PHF8 Assay: The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction condit...				Bioorg Med Chem Lett 17: 1584-9 (2007) BindingDB Entry DOI: 10.7270/Q2FT8PBQ
					More data for this Ligand-Target Pair
Homo sapiens lysine demethylase 2A (KDM2A) (Homo sapiens (Human))	BDBM276044 (2-[1-[2-(2-chlorophenyl)ethyl]imidazol-4-yl]-4-(1H...) Show SMILES Clc1ccccc1CCn1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1 Show InChI InChI=1S/C18H15ClN6/c19-15-4-2-1-3-13(15)6-8-25-11-18(21-12-25)16-9-14(5-7-20-16)17-10-22-24-23-17/h1-5,7,9-12H,6,8H2,(H,22,23,24)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of FBXL11 was determined in 384-well plate format under the following reaction conditions: 0.15...				US Patent US10174003 (2019) BindingDB Entry DOI: 10.7270/Q2417053
					More data for this Ligand-Target Pair