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SMILES: Clc1cccc(Cn2cnc(c2)-c2cc(ccn2)-c2nn[nH]c2C#N)c1Cl

InChI Key: InChIKey=NDYPWCYOQWUTQR-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 276052   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM276052 (4-[2-[1-[(2,3-dichlorophenyl)methyl]imidazol-4-yl]...) Show SMILES Clc1cccc(Cn2cnc(c2)-c2cc(ccn2)-c2nn[nH]c2C#N)c1Cl Show InChI InChI=1S/C18H11Cl2N7/c19-13-3-1-2-12(17(13)20)8-27-9-16(23-10-27)14-6-11(4-5-22-14)18-15(7-21)24-26-25-18/h1-6,9-10H,8H2,(H,24,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	25
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...				US Patent US10071984 (2018) BindingDB Entry DOI: 10.7270/Q24Q7X0X
					More data for this Ligand-Target Pair
Histone lysine demethylase PHF8 (Homo sapiens (Human))	BDBM276052 (4-[2-[1-[(2,3-dichlorophenyl)methyl]imidazol-4-yl]...) Show SMILES Clc1cccc(Cn2cnc(c2)-c2cc(ccn2)-c2nn[nH]c2C#N)c1Cl Show InChI InChI=1S/C18H11Cl2N7/c19-13-3-1-2-12(17(13)20)8-27-9-16(23-10-27)14-6-11(4-5-22-14)18-15(7-21)24-26-25-18/h1-6,9-10H,8H2,(H,24,25,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>500	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description PHF8 Assay: The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction condit...				Bioorg Med Chem Lett 17: 1584-9 (2007) BindingDB Entry DOI: 10.7270/Q2FT8PBQ
					More data for this Ligand-Target Pair
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM276052 (4-[2-[1-[(2,3-dichlorophenyl)methyl]imidazol-4-yl]...) Show SMILES Clc1cccc(Cn2cnc(c2)-c2cc(ccn2)-c2nn[nH]c2C#N)c1Cl Show InChI InChI=1S/C18H11Cl2N7/c19-13-3-1-2-12(17(13)20)8-27-9-16(23-10-27)14-6-11(4-5-22-14)18-15(7-21)24-26-25-18/h1-6,9-10H,8H2,(H,24,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...				Bioorg Med Chem Lett 17: 1584-9 (2007) BindingDB Entry DOI: 10.7270/Q2FT8PBQ
					More data for this Ligand-Target Pair
Isoform 2 of Histone lysine demethylase PHF8 (2) (Homo sapiens (Human))	BDBM276052 (4-[2-[1-[(2,3-dichlorophenyl)methyl]imidazol-4-yl]...) Show SMILES Clc1cccc(Cn2cnc(c2)-c2cc(ccn2)-c2nn[nH]c2C#N)c1Cl Show InChI InChI=1S/C18H11Cl2N7/c19-13-3-1-2-12(17(13)20)8-27-9-16(23-10-27)14-6-11(4-5-22-14)18-15(7-21)24-26-25-18/h1-6,9-10H,8H2,(H,24,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	25
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction conditions: 3 nM P...				US Patent US10071984 (2018) BindingDB Entry DOI: 10.7270/Q24Q7X0X
					More data for this Ligand-Target Pair