BDBM276064 2-[1-[[2-fluoro-3-(trifluoromethoxy)phenyl]methyl]imidazol-44-yl]-4-(1H-triazol-4-yl)pyridine::US10071984, Example 26::US10174003, Example 26::US9896436, Example 26

SMILES: Fc1c(Cn2cnc(c2)-c2cc(ccn2)-c2c[nH]nn2)cccc1OC(F)(F)F

InChI Key: InChIKey=NZTCCZUHIHSENS-UHFFFAOYSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 276064   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM276064 (2-[1-[[2-fluoro-3-(trifluoromethoxy)phenyl]methyl]...) Show SMILES Fc1c(Cn2cnc(c2)-c2cc(ccn2)-c2c[nH]nn2)cccc1OC(F)(F)F Show InChI InChI=1S/C18H12F4N6O/c19-17-12(2-1-3-16(17)29-18(20,21)22)8-28-9-15(24-10-28)13-6-11(4-5-23-13)14-7-25-27-26-14/h1-7,9-10H,8H2,(H,25,26,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	25
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...				US Patent US10071984 (2018) BindingDB Entry DOI: 10.7270/Q24Q7X0X
					More data for this Ligand-Target Pair
Histone lysine demethylase PHF8 (2) (Homo sapiens (Human))	BDBM276064 (2-[1-[[2-fluoro-3-(trifluoromethoxy)phenyl]methyl]...) Show SMILES Fc1c(Cn2cnc(c2)-c2cc(ccn2)-c2c[nH]nn2)cccc1OC(F)(F)F Show InChI InChI=1S/C18H12F4N6O/c19-17-12(2-1-3-16(17)29-18(20,21)22)8-28-9-15(24-10-28)13-6-11(4-5-23-13)14-7-25-27-26-14/h1-7,9-10H,8H2,(H,25,26,27)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	25
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction conditions: 3 nM P...				US Patent US10071984 (2018) BindingDB Entry DOI: 10.7270/Q24Q7X0X
					More data for this Ligand-Target Pair
Histone lysine demethylase PHF8 (Homo sapiens (Human))	BDBM276064 (2-[1-[[2-fluoro-3-(trifluoromethoxy)phenyl]methyl]...) Show SMILES Fc1c(Cn2cnc(c2)-c2cc(ccn2)-c2c[nH]nn2)cccc1OC(F)(F)F Show InChI InChI=1S/C18H12F4N6O/c19-17-12(2-1-3-16(17)29-18(20,21)22)8-28-9-15(24-10-28)13-6-11(4-5-23-13)14-7-25-27-26-14/h1-7,9-10H,8H2,(H,25,26,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>500	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description PHF8 Assay: The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction condit...				Bioorg Med Chem Lett 17: 1584-9 (2007) BindingDB Entry DOI: 10.7270/Q2FT8PBQ
					More data for this Ligand-Target Pair
Histone lysine demethylase PHF8 (Homo sapiens (Human))	BDBM276064 (2-[1-[[2-fluoro-3-(trifluoromethoxy)phenyl]methyl]...) Show SMILES Fc1c(Cn2cnc(c2)-c2cc(ccn2)-c2c[nH]nn2)cccc1OC(F)(F)F Show InChI InChI=1S/C18H12F4N6O/c19-17-12(2-1-3-16(17)29-18(20,21)22)8-28-9-15(24-10-28)13-6-11(4-5-23-13)14-7-25-27-26-14/h1-7,9-10H,8H2,(H,25,26,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction conditions: 3 nM P...				US Patent US10174003 (2019) BindingDB Entry DOI: 10.7270/Q2417053
					More data for this Ligand-Target Pair
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM276064 (2-[1-[[2-fluoro-3-(trifluoromethoxy)phenyl]methyl]...) Show SMILES Fc1c(Cn2cnc(c2)-c2cc(ccn2)-c2c[nH]nn2)cccc1OC(F)(F)F Show InChI InChI=1S/C18H12F4N6O/c19-17-12(2-1-3-16(17)29-18(20,21)22)8-28-9-15(24-10-28)13-6-11(4-5-23-13)14-7-25-27-26-14/h1-7,9-10H,8H2,(H,25,26,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...				Bioorg Med Chem Lett 17: 1584-9 (2007) BindingDB Entry DOI: 10.7270/Q2FT8PBQ
					More data for this Ligand-Target Pair
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM276064 (2-[1-[[2-fluoro-3-(trifluoromethoxy)phenyl]methyl]...) Show SMILES Fc1c(Cn2cnc(c2)-c2cc(ccn2)-c2c[nH]nn2)cccc1OC(F)(F)F Show InChI InChI=1S/C18H12F4N6O/c19-17-12(2-1-3-16(17)29-18(20,21)22)8-28-9-15(24-10-28)13-6-11(4-5-23-13)14-7-25-27-26-14/h1-7,9-10H,8H2,(H,25,26,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...				US Patent US10174003 (2019) BindingDB Entry DOI: 10.7270/Q2417053
					More data for this Ligand-Target Pair