BDBM276066 2-[1-[(2-fluoro-3-methylphenyl)methyl]imidazol-4-yl]-4-(1H-triazol-4-yl)pyridin::US10071984, Example 28::US10174003, Example 28::US9896436, Example 28

SMILES: Cc1cccc(Cn2cnc(c2)-c2cc(ccn2)-c2c[nH]nn2)c1F

InChI Key: InChIKey=LGVMSGMOXACFLZ-UHFFFAOYSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 276066   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM276066 (2-[1-[(2-fluoro-3-methylphenyl)methyl]imidazol-4-y...) Show SMILES Cc1cccc(Cn2cnc(c2)-c2cc(ccn2)-c2c[nH]nn2)c1F Show InChI InChI=1S/C18H15FN6/c1-12-3-2-4-14(18(12)19)9-25-10-17(21-11-25)15-7-13(5-6-20-15)16-8-22-24-23-16/h2-8,10-11H,9H2,1H3,(H,22,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	25
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...				US Patent US10071984 (2018) BindingDB Entry DOI: 10.7270/Q24Q7X0X
					More data for this Ligand-Target Pair
histone lysine demethylase PHF8 isoform 2 (Homo sapiens (Human))	BDBM276066 (2-[1-[(2-fluoro-3-methylphenyl)methyl]imidazol-4-y...) Show SMILES Cc1cccc(Cn2cnc(c2)-c2cc(ccn2)-c2c[nH]nn2)c1F Show InChI InChI=1S/C18H15FN6/c1-12-3-2-4-14(18(12)19)9-25-10-17(21-11-25)15-7-13(5-6-20-15)16-8-22-24-23-16/h2-8,10-11H,9H2,1H3,(H,22,23,24)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	25
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction conditions: 3 nM P...				US Patent US10071984 (2018) BindingDB Entry DOI: 10.7270/Q24Q7X0X
					More data for this Ligand-Target Pair
Histone lysine demethylase PHF8 (Homo sapiens (Human))	BDBM276066 (2-[1-[(2-fluoro-3-methylphenyl)methyl]imidazol-4-y...) Show SMILES Cc1cccc(Cn2cnc(c2)-c2cc(ccn2)-c2c[nH]nn2)c1F Show InChI InChI=1S/C18H15FN6/c1-12-3-2-4-14(18(12)19)9-25-10-17(21-11-25)15-7-13(5-6-20-15)16-8-22-24-23-16/h2-8,10-11H,9H2,1H3,(H,22,23,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description PHF8 Assay: The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction condit...				Bioorg Med Chem Lett 17: 1584-9 (2007) BindingDB Entry DOI: 10.7270/Q2FT8PBQ
					More data for this Ligand-Target Pair
Histone lysine demethylase PHF8 (Homo sapiens (Human))	BDBM276066 (2-[1-[(2-fluoro-3-methylphenyl)methyl]imidazol-4-y...) Show SMILES Cc1cccc(Cn2cnc(c2)-c2cc(ccn2)-c2c[nH]nn2)c1F Show InChI InChI=1S/C18H15FN6/c1-12-3-2-4-14(18(12)19)9-25-10-17(21-11-25)15-7-13(5-6-20-15)16-8-22-24-23-16/h2-8,10-11H,9H2,1H3,(H,22,23,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction conditions: 3 nM P...				US Patent US10174003 (2019) BindingDB Entry DOI: 10.7270/Q2417053
					More data for this Ligand-Target Pair
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM276066 (2-[1-[(2-fluoro-3-methylphenyl)methyl]imidazol-4-y...) Show SMILES Cc1cccc(Cn2cnc(c2)-c2cc(ccn2)-c2c[nH]nn2)c1F Show InChI InChI=1S/C18H15FN6/c1-12-3-2-4-14(18(12)19)9-25-10-17(21-11-25)15-7-13(5-6-20-15)16-8-22-24-23-16/h2-8,10-11H,9H2,1H3,(H,22,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...				Bioorg Med Chem Lett 17: 1584-9 (2007) BindingDB Entry DOI: 10.7270/Q2FT8PBQ
					More data for this Ligand-Target Pair
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM276066 (2-[1-[(2-fluoro-3-methylphenyl)methyl]imidazol-4-y...) Show SMILES Cc1cccc(Cn2cnc(c2)-c2cc(ccn2)-c2c[nH]nn2)c1F Show InChI InChI=1S/C18H15FN6/c1-12-3-2-4-14(18(12)19)9-25-10-17(21-11-25)15-7-13(5-6-20-15)16-8-22-24-23-16/h2-8,10-11H,9H2,1H3,(H,22,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...				US Patent US10174003 (2019) BindingDB Entry DOI: 10.7270/Q2417053
					More data for this Ligand-Target Pair