BDBM276073 4-(5-fluoro-1H-triazol-4-yl)-2-[1-(2-naphthalen-1-ylethyl)imidazol-4-yl]pyridine::US10071984, Example 35::US10174003, Example 35::US9896436, Example 35
SMILES: Fc1[nH]nnc1-c1ccnc(c1)-c1cn(CCc2cccc3ccccc23)cn1
InChI Key: InChIKey=LTPQCYDCWHATJI-UHFFFAOYSA-N
Data: 6 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Lysine-specific demethylase 2B (Homo sapiens (Human)) | BDBM276073 (4-(5-fluoro-1H-triazol-4-yl)-2-[1-(2-naphthalen-1-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | 25 |
Celgene Quanticel Research, Inc. US Patent | Assay Description The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ... | US Patent US10071984 (2018) BindingDB Entry DOI: 10.7270/Q24Q7X0X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
histone lysine demethylase PHF8 isoform 2 (Homo sapiens (Human)) | BDBM276073 (4-(5-fluoro-1H-triazol-4-yl)-2-[1-(2-naphthalen-1-...) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 550 | n/a | n/a | n/a | n/a | n/a | 25 |
Celgene Quanticel Research, Inc. US Patent | Assay Description The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction conditions: 3 nM P... | US Patent US10071984 (2018) BindingDB Entry DOI: 10.7270/Q24Q7X0X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone lysine demethylase PHF8 (Homo sapiens (Human)) | BDBM276073 (4-(5-fluoro-1H-triazol-4-yl)-2-[1-(2-naphthalen-1-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
GSK | Assay Description PHF8 Assay: The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction condit... | Bioorg Med Chem Lett 17: 1584-9 (2007) BindingDB Entry DOI: 10.7270/Q2FT8PBQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone lysine demethylase PHF8 (Homo sapiens (Human)) | BDBM276073 (4-(5-fluoro-1H-triazol-4-yl)-2-[1-(2-naphthalen-1-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 550 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Quanticel Research, Inc. US Patent | Assay Description The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction conditions: 3 nM P... | US Patent US10174003 (2019) BindingDB Entry DOI: 10.7270/Q2417053 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysine-specific demethylase 2B (Homo sapiens (Human)) | BDBM276073 (4-(5-fluoro-1H-triazol-4-yl)-2-[1-(2-naphthalen-1-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
GSK | Assay Description The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ... | Bioorg Med Chem Lett 17: 1584-9 (2007) BindingDB Entry DOI: 10.7270/Q2FT8PBQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysine-specific demethylase 2B (Homo sapiens (Human)) | BDBM276073 (4-(5-fluoro-1H-triazol-4-yl)-2-[1-(2-naphthalen-1-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Quanticel Research, Inc. US Patent | Assay Description The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ... | US Patent US10174003 (2019) BindingDB Entry DOI: 10.7270/Q2417053 | |||||||||||
More data for this Ligand-Target Pair |