null

SMILES: Cn1cnc(c1-c1ccc(F)cc1OCC1CC1)-c1cc(ccn1)-c1nn[nH]c1[N+]#[C-]

InChI Key: InChIKey=DABPDMJCBJOCIH-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 276077   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM276077 (4-[2-[5-[2-(cyclopropylmethoxy)-4-fluorophenyl]-1-...) Show SMILES Cn1cnc(c1-c1ccc(F)cc1OCC1CC1)-c1cc(ccn1)-c1nn[nH]c1[N+]#[C-] |(2.9,-3.53,;1.41,-3.92,;.5,-5.17,;-.96,-4.69,;-.96,-3.15,;.5,-2.68,;.9,-1.19,;-.19,-.1,;.21,1.39,;1.7,1.78,;2.1,3.27,;2.79,.7,;2.39,-.79,;3.48,-1.88,;4.97,-1.48,;6.05,-2.57,;6.45,-4.06,;7.54,-2.97,;-2.3,-2.38,;-2.3,-.84,;-3.63,-.07,;-4.96,-.84,;-4.96,-2.38,;-3.63,-3.15,;-3.63,1.47,;-2.38,2.37,;-2.86,3.84,;-4.4,3.84,;-4.91,2.36,;-6.38,1.88,;-7.84,1.41,)| Show InChI InChI=1S/C22H18FN7O/c1-24-22-19(27-29-28-22)14-7-8-25-17(9-14)20-21(30(2)12-26-20)16-6-5-15(23)10-18(16)31-11-13-3-4-13/h5-10,12-13H,3-4,11H2,2H3,(H,27,28,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	25
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...				US Patent US10071984 (2018) BindingDB Entry DOI: 10.7270/Q24Q7X0X
					More data for this Ligand-Target Pair
Histone lysine demethylase PHF8 (Homo sapiens (Human))	BDBM276077 (4-[2-[5-[2-(cyclopropylmethoxy)-4-fluorophenyl]-1-...) Show SMILES Cn1cnc(c1-c1ccc(F)cc1OCC1CC1)-c1cc(ccn1)-c1nn[nH]c1[N+]#[C-] |(2.9,-3.53,;1.41,-3.92,;.5,-5.17,;-.96,-4.69,;-.96,-3.15,;.5,-2.68,;.9,-1.19,;-.19,-.1,;.21,1.39,;1.7,1.78,;2.1,3.27,;2.79,.7,;2.39,-.79,;3.48,-1.88,;4.97,-1.48,;6.05,-2.57,;6.45,-4.06,;7.54,-2.97,;-2.3,-2.38,;-2.3,-.84,;-3.63,-.07,;-4.96,-.84,;-4.96,-2.38,;-3.63,-3.15,;-3.63,1.47,;-2.38,2.37,;-2.86,3.84,;-4.4,3.84,;-4.91,2.36,;-6.38,1.88,;-7.84,1.41,)| Show InChI InChI=1S/C22H18FN7O/c1-24-22-19(27-29-28-22)14-7-8-25-17(9-14)20-21(30(2)12-26-20)16-6-5-15(23)10-18(16)31-11-13-3-4-13/h5-10,12-13H,3-4,11H2,2H3,(H,27,28,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction conditions: 3 nM P...				US Patent US10174003 (2019) BindingDB Entry DOI: 10.7270/Q2417053
					More data for this Ligand-Target Pair
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM276077 (4-[2-[5-[2-(cyclopropylmethoxy)-4-fluorophenyl]-1-...) Show SMILES Cn1cnc(c1-c1ccc(F)cc1OCC1CC1)-c1cc(ccn1)-c1nn[nH]c1[N+]#[C-] |(2.9,-3.53,;1.41,-3.92,;.5,-5.17,;-.96,-4.69,;-.96,-3.15,;.5,-2.68,;.9,-1.19,;-.19,-.1,;.21,1.39,;1.7,1.78,;2.1,3.27,;2.79,.7,;2.39,-.79,;3.48,-1.88,;4.97,-1.48,;6.05,-2.57,;6.45,-4.06,;7.54,-2.97,;-2.3,-2.38,;-2.3,-.84,;-3.63,-.07,;-4.96,-.84,;-4.96,-2.38,;-3.63,-3.15,;-3.63,1.47,;-2.38,2.37,;-2.86,3.84,;-4.4,3.84,;-4.91,2.36,;-6.38,1.88,;-7.84,1.41,)| Show InChI InChI=1S/C22H18FN7O/c1-24-22-19(27-29-28-22)14-7-8-25-17(9-14)20-21(30(2)12-26-20)16-6-5-15(23)10-18(16)31-11-13-3-4-13/h5-10,12-13H,3-4,11H2,2H3,(H,27,28,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...				US Patent US10174003 (2019) BindingDB Entry DOI: 10.7270/Q2417053
					More data for this Ligand-Target Pair
Isoform 2 of Histone lysine demethylase PHF8 (2) (Homo sapiens (Human))	BDBM276077 (4-[2-[5-[2-(cyclopropylmethoxy)-4-fluorophenyl]-1-...) Show SMILES Cn1cnc(c1-c1ccc(F)cc1OCC1CC1)-c1cc(ccn1)-c1nn[nH]c1[N+]#[C-] |(2.9,-3.53,;1.41,-3.92,;.5,-5.17,;-.96,-4.69,;-.96,-3.15,;.5,-2.68,;.9,-1.19,;-.19,-.1,;.21,1.39,;1.7,1.78,;2.1,3.27,;2.79,.7,;2.39,-.79,;3.48,-1.88,;4.97,-1.48,;6.05,-2.57,;6.45,-4.06,;7.54,-2.97,;-2.3,-2.38,;-2.3,-.84,;-3.63,-.07,;-4.96,-.84,;-4.96,-2.38,;-3.63,-3.15,;-3.63,1.47,;-2.38,2.37,;-2.86,3.84,;-4.4,3.84,;-4.91,2.36,;-6.38,1.88,;-7.84,1.41,)| Show InChI InChI=1S/C22H18FN7O/c1-24-22-19(27-29-28-22)14-7-8-25-17(9-14)20-21(30(2)12-26-20)16-6-5-15(23)10-18(16)31-11-13-3-4-13/h5-10,12-13H,3-4,11H2,2H3,(H,27,28,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	25
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction conditions: 3 nM P...				US Patent US10071984 (2018) BindingDB Entry DOI: 10.7270/Q24Q7X0X
					More data for this Ligand-Target Pair