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SMILES: Cn1cnc(c1-c1ccc(F)cc1)-c1cc2[nH]nnc2cn1

InChI Key: InChIKey=DFIZSWCEVFIDEP-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 276091   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM276091 (5-(4-fluorophenyl)-1-methyl-4-{1H-[1,2,3]triazolo[...) Show SMILES Cn1cnc(c1-c1ccc(F)cc1)-c1cc2[nH]nnc2cn1 Show InChI InChI=1S/C15H11FN6/c1-22-8-18-14(15(22)9-2-4-10(16)5-3-9)12-6-11-13(7-17-12)20-21-19-11/h2-8H,1H3,(H,19,20,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	25
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...				US Patent US10071984 (2018) BindingDB Entry DOI: 10.7270/Q24Q7X0X
					More data for this Ligand-Target Pair
Isoform 2 of Histone lysine demethylase PHF8 (2) (Homo sapiens (Human))	BDBM276091 (5-(4-fluorophenyl)-1-methyl-4-{1H-[1,2,3]triazolo[...) Show SMILES Cn1cnc(c1-c1ccc(F)cc1)-c1cc2[nH]nnc2cn1 Show InChI InChI=1S/C15H11FN6/c1-22-8-18-14(15(22)9-2-4-10(16)5-3-9)12-6-11-13(7-17-12)20-21-19-11/h2-8H,1H3,(H,19,20,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	25
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction conditions: 3 nM P...				US Patent US10071984 (2018) BindingDB Entry DOI: 10.7270/Q24Q7X0X
					More data for this Ligand-Target Pair
Histone lysine demethylase PHF8 (Homo sapiens (Human))	BDBM276091 (5-(4-fluorophenyl)-1-methyl-4-{1H-[1,2,3]triazolo[...) Show SMILES Cn1cnc(c1-c1ccc(F)cc1)-c1cc2[nH]nnc2cn1 Show InChI InChI=1S/C15H11FN6/c1-22-8-18-14(15(22)9-2-4-10(16)5-3-9)12-6-11-13(7-17-12)20-21-19-11/h2-8H,1H3,(H,19,20,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>500	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description PHF8 Assay: The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction condit...				Bioorg Med Chem Lett 17: 1584-9 (2007) BindingDB Entry DOI: 10.7270/Q2FT8PBQ
					More data for this Ligand-Target Pair
Histone lysine demethylase PHF8 (Homo sapiens (Human))	BDBM276091 (5-(4-fluorophenyl)-1-methyl-4-{1H-[1,2,3]triazolo[...) Show SMILES Cn1cnc(c1-c1ccc(F)cc1)-c1cc2[nH]nnc2cn1 Show InChI InChI=1S/C15H11FN6/c1-22-8-18-14(15(22)9-2-4-10(16)5-3-9)12-6-11-13(7-17-12)20-21-19-11/h2-8H,1H3,(H,19,20,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction conditions: 3 nM P...				US Patent US10174003 (2019) BindingDB Entry DOI: 10.7270/Q2417053
					More data for this Ligand-Target Pair
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM276091 (5-(4-fluorophenyl)-1-methyl-4-{1H-[1,2,3]triazolo[...) Show SMILES Cn1cnc(c1-c1ccc(F)cc1)-c1cc2[nH]nnc2cn1 Show InChI InChI=1S/C15H11FN6/c1-22-8-18-14(15(22)9-2-4-10(16)5-3-9)12-6-11-13(7-17-12)20-21-19-11/h2-8H,1H3,(H,19,20,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...				Bioorg Med Chem Lett 17: 1584-9 (2007) BindingDB Entry DOI: 10.7270/Q2FT8PBQ
					More data for this Ligand-Target Pair
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM276091 (5-(4-fluorophenyl)-1-methyl-4-{1H-[1,2,3]triazolo[...) Show SMILES Cn1cnc(c1-c1ccc(F)cc1)-c1cc2[nH]nnc2cn1 Show InChI InChI=1S/C15H11FN6/c1-22-8-18-14(15(22)9-2-4-10(16)5-3-9)12-6-11-13(7-17-12)20-21-19-11/h2-8H,1H3,(H,19,20,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...				US Patent US10174003 (2019) BindingDB Entry DOI: 10.7270/Q2417053
					More data for this Ligand-Target Pair