BDBM276092 5-[2-(cyclopropylmethoxy)-4-fluorophenyl]-1-methyl-4-{1H-[1,2,3]triazolo[4,5-c]pyridin-6-yl}-1H-imidazole::US10071984, Example 54::US10174003, Example 54::US9896436, Example 54

SMILES: Cn1cnc(c1-c1ccc(F)cc1OCC1CC1)-c1cc2[nH]nnc2cn1

InChI Key: InChIKey=IJEOCHNJDZZTLK-UHFFFAOYSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 276092   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM276092 (5-[2-(cyclopropylmethoxy)-4-fluorophenyl]-1-methyl...) Show SMILES Cn1cnc(c1-c1ccc(F)cc1OCC1CC1)-c1cc2[nH]nnc2cn1 |(2.41,-2.3,;.92,-2.7,;.45,-4.16,;-1.09,-4.16,;-1.57,-2.7,;-.32,-1.79,;.07,-.3,;-1.01,.79,;-.62,2.27,;.87,2.67,;1.27,4.16,;1.96,1.58,;1.56,.1,;2.65,-.99,;4.14,-.59,;5.23,-1.68,;5.63,-3.17,;6.72,-2.08,;-2.9,-1.93,;-2.9,-.39,;-4.24,.38,;-4.56,1.89,;-6.09,2.05,;-6.72,.65,;-5.57,-.39,;-5.57,-1.93,;-4.24,-2.7,)| Show InChI InChI=1S/C19H17FN6O/c1-26-10-22-18(15-7-14-16(8-21-15)24-25-23-14)19(26)13-5-4-12(20)6-17(13)27-9-11-2-3-11/h4-8,10-11H,2-3,9H2,1H3,(H,23,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	25
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...				US Patent US10071984 (2018) BindingDB Entry DOI: 10.7270/Q24Q7X0X
					More data for this Ligand-Target Pair
Histone lysine demethylase PHF8 (2) (Homo sapiens (Human))	BDBM276092 (5-[2-(cyclopropylmethoxy)-4-fluorophenyl]-1-methyl...) Show SMILES Cn1cnc(c1-c1ccc(F)cc1OCC1CC1)-c1cc2[nH]nnc2cn1 |(2.41,-2.3,;.92,-2.7,;.45,-4.16,;-1.09,-4.16,;-1.57,-2.7,;-.32,-1.79,;.07,-.3,;-1.01,.79,;-.62,2.27,;.87,2.67,;1.27,4.16,;1.96,1.58,;1.56,.1,;2.65,-.99,;4.14,-.59,;5.23,-1.68,;5.63,-3.17,;6.72,-2.08,;-2.9,-1.93,;-2.9,-.39,;-4.24,.38,;-4.56,1.89,;-6.09,2.05,;-6.72,.65,;-5.57,-.39,;-5.57,-1.93,;-4.24,-2.7,)| Show InChI InChI=1S/C19H17FN6O/c1-26-10-22-18(15-7-14-16(8-21-15)24-25-23-14)19(26)13-5-4-12(20)6-17(13)27-9-11-2-3-11/h4-8,10-11H,2-3,9H2,1H3,(H,23,24,25)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	25
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction conditions: 3 nM P...				US Patent US10071984 (2018) BindingDB Entry DOI: 10.7270/Q24Q7X0X
					More data for this Ligand-Target Pair
Histone lysine demethylase PHF8 (Homo sapiens (Human))	BDBM276092 (5-[2-(cyclopropylmethoxy)-4-fluorophenyl]-1-methyl...) Show SMILES Cn1cnc(c1-c1ccc(F)cc1OCC1CC1)-c1cc2[nH]nnc2cn1 |(2.41,-2.3,;.92,-2.7,;.45,-4.16,;-1.09,-4.16,;-1.57,-2.7,;-.32,-1.79,;.07,-.3,;-1.01,.79,;-.62,2.27,;.87,2.67,;1.27,4.16,;1.96,1.58,;1.56,.1,;2.65,-.99,;4.14,-.59,;5.23,-1.68,;5.63,-3.17,;6.72,-2.08,;-2.9,-1.93,;-2.9,-.39,;-4.24,.38,;-4.56,1.89,;-6.09,2.05,;-6.72,.65,;-5.57,-.39,;-5.57,-1.93,;-4.24,-2.7,)| Show InChI InChI=1S/C19H17FN6O/c1-26-10-22-18(15-7-14-16(8-21-15)24-25-23-14)19(26)13-5-4-12(20)6-17(13)27-9-11-2-3-11/h4-8,10-11H,2-3,9H2,1H3,(H,23,24,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>500	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description PHF8 Assay: The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction condit...				Bioorg Med Chem Lett 17: 1584-9 (2007) BindingDB Entry DOI: 10.7270/Q2FT8PBQ
					More data for this Ligand-Target Pair
Histone lysine demethylase PHF8 (Homo sapiens (Human))	BDBM276092 (5-[2-(cyclopropylmethoxy)-4-fluorophenyl]-1-methyl...) Show SMILES Cn1cnc(c1-c1ccc(F)cc1OCC1CC1)-c1cc2[nH]nnc2cn1 |(2.41,-2.3,;.92,-2.7,;.45,-4.16,;-1.09,-4.16,;-1.57,-2.7,;-.32,-1.79,;.07,-.3,;-1.01,.79,;-.62,2.27,;.87,2.67,;1.27,4.16,;1.96,1.58,;1.56,.1,;2.65,-.99,;4.14,-.59,;5.23,-1.68,;5.63,-3.17,;6.72,-2.08,;-2.9,-1.93,;-2.9,-.39,;-4.24,.38,;-4.56,1.89,;-6.09,2.05,;-6.72,.65,;-5.57,-.39,;-5.57,-1.93,;-4.24,-2.7,)| Show InChI InChI=1S/C19H17FN6O/c1-26-10-22-18(15-7-14-16(8-21-15)24-25-23-14)19(26)13-5-4-12(20)6-17(13)27-9-11-2-3-11/h4-8,10-11H,2-3,9H2,1H3,(H,23,24,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of PHF8 was determined in 384-well plate format under the following reaction conditions: 3 nM P...				US Patent US10174003 (2019) BindingDB Entry DOI: 10.7270/Q2417053
					More data for this Ligand-Target Pair
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM276092 (5-[2-(cyclopropylmethoxy)-4-fluorophenyl]-1-methyl...) Show SMILES Cn1cnc(c1-c1ccc(F)cc1OCC1CC1)-c1cc2[nH]nnc2cn1 |(2.41,-2.3,;.92,-2.7,;.45,-4.16,;-1.09,-4.16,;-1.57,-2.7,;-.32,-1.79,;.07,-.3,;-1.01,.79,;-.62,2.27,;.87,2.67,;1.27,4.16,;1.96,1.58,;1.56,.1,;2.65,-.99,;4.14,-.59,;5.23,-1.68,;5.63,-3.17,;6.72,-2.08,;-2.9,-1.93,;-2.9,-.39,;-4.24,.38,;-4.56,1.89,;-6.09,2.05,;-6.72,.65,;-5.57,-.39,;-5.57,-1.93,;-4.24,-2.7,)| Show InChI InChI=1S/C19H17FN6O/c1-26-10-22-18(15-7-14-16(8-21-15)24-25-23-14)19(26)13-5-4-12(20)6-17(13)27-9-11-2-3-11/h4-8,10-11H,2-3,9H2,1H3,(H,23,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...				Bioorg Med Chem Lett 17: 1584-9 (2007) BindingDB Entry DOI: 10.7270/Q2FT8PBQ
					More data for this Ligand-Target Pair
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM276092 (5-[2-(cyclopropylmethoxy)-4-fluorophenyl]-1-methyl...) Show SMILES Cn1cnc(c1-c1ccc(F)cc1OCC1CC1)-c1cc2[nH]nnc2cn1 |(2.41,-2.3,;.92,-2.7,;.45,-4.16,;-1.09,-4.16,;-1.57,-2.7,;-.32,-1.79,;.07,-.3,;-1.01,.79,;-.62,2.27,;.87,2.67,;1.27,4.16,;1.96,1.58,;1.56,.1,;2.65,-.99,;4.14,-.59,;5.23,-1.68,;5.63,-3.17,;6.72,-2.08,;-2.9,-1.93,;-2.9,-.39,;-4.24,.38,;-4.56,1.89,;-6.09,2.05,;-6.72,.65,;-5.57,-.39,;-5.57,-1.93,;-4.24,-2.7,)| Show InChI InChI=1S/C19H17FN6O/c1-26-10-22-18(15-7-14-16(8-21-15)24-25-23-14)19(26)13-5-4-12(20)6-17(13)27-9-11-2-3-11/h4-8,10-11H,2-3,9H2,1H3,(H,23,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...				US Patent US10174003 (2019) BindingDB Entry DOI: 10.7270/Q2417053
					More data for this Ligand-Target Pair