BDBM276355 5-Chloro-2-[[1-[3-(1,1-difluoroethyl)phenyl]triazol-4-::US10071988, Example 294::US10233173, Example 294

SMILES: CC(F)(F)c1cccc(c1)-n1cc(COc2ncc(Cl)cn2)nn1

InChI Key: InChIKey=SAYVLXHJEFSMFG-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 276355   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
GluN1/GluN2B NMDA receptor (Homo sapiens (Human))	BDBM276355 (5-Chloro-2-[[1-[3-(1,1-difluoroethyl)phenyl]triazo...) Show SMILES CC(F)(F)c1cccc(c1)-n1cc(COc2ncc(Cl)cn2)nn1 Show InChI InChI=1S/C15H12ClF2N5O/c1-15(17,18)10-3-2-4-13(5-10)23-8-12(21-22-23)9-24-14-19-6-11(16)7-20-14/h2-8H,9H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Lund University					Assay Description NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...				Bioorg Med Chem 14: 1215-20 (2006) BindingDB Entry DOI: 10.7270/Q23R0W6K
					More data for this Ligand-Target Pair
Retinoic acid receptor RXR-alpha (Homo sapiens (Human))	BDBM276355 (5-Chloro-2-[[1-[3-(1,1-difluoroethyl)phenyl]triazo...) Show SMILES CC(F)(F)c1cccc(c1)-n1cc(COc2ncc(Cl)cn2)nn1 Show InChI InChI=1S/C15H12ClF2N5O/c1-15(17,18)10-3-2-4-13(5-10)23-8-12(21-22-23)9-24-14-19-6-11(16)7-20-14/h2-8H,9H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	7.4	25
JANSSEN PHARMACEUTICA NV US Patent					Assay Description NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...				US Patent US10071988 (2018) BindingDB Entry DOI: 10.7270/Q20Z7591
					More data for this Ligand-Target Pair