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BDBM276468 2-[[1-[3-(Difluoromethyl)-4-fluoro-phenyl]triazol-4-yl]methoxy]-5-::US10071988, Example 407::US10233173, Example 407

SMILES: Cc1nc(OCc2cn(nn2)-c2ccc(F)c(c2)C(F)F)ncc1F

InChI Key: InChIKey=GYZVAUNIHWKONN-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 276468   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
GluN1/GluN2B NMDA receptor


(Homo sapiens (Human))
BDBM276468
PNG
(2-[[1-[3-(Difluoromethyl)-4-fluoro-phenyl]triazol-...)
Show SMILES Cc1nc(OCc2cn(nn2)-c2ccc(F)c(c2)C(F)F)ncc1F
Show InChI InChI=1S/C15H11F4N5O/c1-8-13(17)5-20-15(21-8)25-7-9-6-24(23-22-9)10-2-3-12(16)11(4-10)14(18)19/h2-6,14H,7H2,1H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1n/an/an/an/an/an/a



Lund University



Assay Description
NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...


Bioorg Med Chem 14: 1215-20 (2006)


BindingDB Entry DOI: 10.7270/Q23R0W6K
More data for this
Ligand-Target Pair
Retinoic acid receptor RXR-alpha


(Homo sapiens (Human))
BDBM276468
PNG
(2-[[1-[3-(Difluoromethyl)-4-fluoro-phenyl]triazol-...)
Show SMILES Cc1nc(OCc2cn(nn2)-c2ccc(F)c(c2)C(F)F)ncc1F
Show InChI InChI=1S/C15H11F4N5O/c1-8-13(17)5-20-15(21-8)25-7-9-6-24(23-22-9)10-2-3-12(16)11(4-10)14(18)19/h2-6,14H,7H2,1H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1n/an/an/an/a7.425



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...


US Patent US10071988 (2018)


BindingDB Entry DOI: 10.7270/Q20Z7591
More data for this
Ligand-Target Pair