BDBM276469 2-[[1-[3-(Difluoromethyl)-4-fluoro-phenyl]triazol-4-yl]methoxy]-4,5-::US10071988, Example 408::US10233173, Example 408

SMILES: Cc1cnc(OCc2cn(nn2)-c2ccc(F)c(c2)C(F)F)nc1C

InChI Key: InChIKey=NVGYKVFFMQKJJU-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 276469   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
GluN1/GluN2B NMDA receptor (Homo sapiens (Human))	BDBM276469 (2-[[1-[3-(Difluoromethyl)-4-fluoro-phenyl]triazol-...) Show SMILES Cc1cnc(OCc2cn(nn2)-c2ccc(F)c(c2)C(F)F)nc1C Show InChI InChI=1S/C16H14F3N5O/c1-9-6-20-16(21-10(9)2)25-8-11-7-24(23-22-11)12-3-4-14(17)13(5-12)15(18)19/h3-7,15H,8H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Lund University					Assay Description NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...				Bioorg Med Chem 14: 1215-20 (2006) BindingDB Entry DOI: 10.7270/Q23R0W6K
					More data for this Ligand-Target Pair
Retinoic acid receptor RXR-alpha (Homo sapiens (Human))	BDBM276469 (2-[[1-[3-(Difluoromethyl)-4-fluoro-phenyl]triazol-...) Show SMILES Cc1cnc(OCc2cn(nn2)-c2ccc(F)c(c2)C(F)F)nc1C Show InChI InChI=1S/C16H14F3N5O/c1-9-6-20-16(21-10(9)2)25-8-11-7-24(23-22-11)12-3-4-14(17)13(5-12)15(18)19/h3-7,15H,8H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	7.4	25
JANSSEN PHARMACEUTICA NV US Patent					Assay Description NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...				US Patent US10071988 (2018) BindingDB Entry DOI: 10.7270/Q20Z7591
					More data for this Ligand-Target Pair