BDBM27688 1,3-dimethyl-1H,4H,5H,6H,7H,8H,9H-pyrazolo[3,4-b]quinolin-4-one::ring-fused pyrazolo pyridin-2-one, 16

SMILES: Cc1nn(C)c2nc3CCCCc3c(O)c12

InChI Key: InChIKey=BRGVVESKICPCPN-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 27688   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM27688 (1,3-dimethyl-1H,4H,5H,6H,7H,8H,9H-pyrazolo[3,4-b]q...) Show SMILES Cc1nn(C)c2nc3CCCCc3c(O)c12 Show InChI InChI=1S/C12H15N3O/c1-7-10-11(16)8-5-3-4-6-9(8)13-12(10)15(2)14-7/h3-6H2,1-2H3,(H,13,16)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	8.0	23
Deltagen Research Laboratories					Assay Description To assess the inhibitory activity of novel inhibitors, the PARP-1 enzyme assay was carried out in reaction mixture consisting of Escherichia coli str...				Bioorg Med Chem Lett 18: 5126-9 (2008) Article DOI: 10.1016/j.bmcl.2008.07.091 BindingDB Entry DOI: 10.7270/Q29S1PCX
					More data for this Ligand-Target Pair