BDBM276981 US10072001, Example 157::US10259811, Example 157
SMILES: OCC(=O)N1CCC(CC1)Oc1ccc(cc1C#N)-c1ncnc2[nH]c(cc12)-c1ccc(cc1)N1CCN(CC1)C1COC1
InChI Key: InChIKey=DVAHGKLQAATZGZ-UHFFFAOYSA-N
Data: 4 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Inhibitor of nuclear factor kappa-B kinase subunit epsilon (Homo sapiens (Human)) | BDBM276981 (US10072001, Example 157 | US10259811, Example 157) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.43 | n/a | n/a | n/a | n/a | 7.0 | n/a |
Gilead Sciences, Inc. US Patent | Assay Description Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m... | US Patent US10072001 (2018) BindingDB Entry DOI: 10.7270/Q27H1MMV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein cereblon/Serine/threonine-protein kinase TBK1 (Homo sapiens (Human)) | BDBM276981 (US10072001, Example 157 | US10259811, Example 157) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.849 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tokyo | Assay Description Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m... | Bioorg Med Chem 16: 4272-85 (2008) BindingDB Entry DOI: 10.7270/Q2ZG6VKC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Inhibitor of nuclear factor kappa-B kinase subunit epsilon (Homo sapiens (Human)) | BDBM276981 (US10072001, Example 157 | US10259811, Example 157) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.43 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tokyo | Assay Description Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m... | Bioorg Med Chem 16: 4272-85 (2008) BindingDB Entry DOI: 10.7270/Q2ZG6VKC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein cereblon/Serine/threonine-protein kinase TBK1 (Homo sapiens (Human)) | BDBM276981 (US10072001, Example 157 | US10259811, Example 157) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.849 | n/a | n/a | n/a | n/a | 7.0 | n/a |
Gilead Sciences, Inc. US Patent | Assay Description Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m... | US Patent US10072001 (2018) BindingDB Entry DOI: 10.7270/Q27H1MMV | |||||||||||
More data for this Ligand-Target Pair |