BDBM27749 3-[(4-fluorophenyl)methyl]-9-hydroxy-5-methoxy-6H,7H,8H-pyrrolo[3,4-g]quinolin-8-one::tricyclic pyrroloquinoline, 9

SMILES: COc1c2CNC(=O)c2c(O)c2ncc(Cc3ccc(F)cc3)cc12

InChI Key: InChIKey=XRBIRQRZNGSARA-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 27749   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
HIV-1 Integrase (Human immunodeficiency virus type 1)	BDBM27749 (3-[(4-fluorophenyl)methyl]-9-hydroxy-5-methoxy-6H,...) Show SMILES COc1c2CNC(=O)c2c(O)c2ncc(Cc3ccc(F)cc3)cc12 Show InChI InChI=1S/C19H15FN2O3/c1-25-18-13-7-11(6-10-2-4-12(20)5-3-10)8-21-16(13)17(23)15-14(18)9-22-19(15)24/h2-5,7-8,23H,6,9H2,1H3,(H,22,24)	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	7.3	22
Gilead Sciences Inc.					Assay Description In the strand-transfer assay, the biotinylated donor DNA was bound to streptavidin-coated plates, and integrase was added to each well to allow proce...				Bioorg Med Chem Lett 19: 1187-90 (2009) Article DOI: 10.1016/j.bmcl.2008.12.079 BindingDB Entry DOI: 10.7270/Q2XG9PGS
					More data for this Ligand-Target Pair