BDBM277721 3-[(5-fluoro-1-pentyl-1H-indazol-3-yl)amino]pyridine-4-carboxylic acid::US10040779, Example 18::US10336727, Example 18::US9617242, Example 18

SMILES: CCCCCn1nc(Nc2cnccc2C(O)=O)c2cc(F)ccc12

InChI Key: InChIKey=CAPANHTUNRFSGB-UHFFFAOYSA-N

Data: 9 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 277721   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Lysine-specific demethylase 5A (Homo sapiens (Human))	BDBM277721 (3-[(5-fluoro-1-pentyl-1H-indazol-3-yl)amino]pyridi...) Show SMILES CCCCCn1nc(Nc2cnccc2C(O)=O)c2cc(F)ccc12 Show InChI InChI=1S/C18H19FN4O2/c1-2-3-4-9-23-16-6-5-12(19)10-14(16)17(22-23)21-15-11-20-8-7-13(15)18(24)25/h5-8,10-11H,2-4,9H2,1H3,(H,21,22)(H,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.100	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...				US Patent US10040779 (2018) BindingDB Entry DOI: 10.7270/Q26H4KF1
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5B (Homo sapiens (Human))	BDBM277721 (3-[(5-fluoro-1-pentyl-1H-indazol-3-yl)amino]pyridi...) Show SMILES CCCCCn1nc(Nc2cnccc2C(O)=O)c2cc(F)ccc12 Show InChI InChI=1S/C18H19FN4O2/c1-2-3-4-9-23-16-6-5-12(19)10-14(16)17(22-23)21-15-11-20-8-7-13(15)18(24)25/h5-8,10-11H,2-4,9H2,1H3,(H,21,22)(H,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.100	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...				US Patent US10040779 (2018) BindingDB Entry DOI: 10.7270/Q26H4KF1
					More data for this Ligand-Target Pair
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM277721 (3-[(5-fluoro-1-pentyl-1H-indazol-3-yl)amino]pyridi...) Show SMILES CCCCCn1nc(Nc2cnccc2C(O)=O)c2cc(F)ccc12 Show InChI InChI=1S/C18H19FN4O2/c1-2-3-4-9-23-16-6-5-12(19)10-14(16)17(22-23)21-15-11-20-8-7-13(15)18(24)25/h5-8,10-11H,2-4,9H2,1H3,(H,21,22)(H,24,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.550	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...				US Patent US10040779 (2018) BindingDB Entry DOI: 10.7270/Q26H4KF1
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5A (Homo sapiens (Human))	BDBM277721 (3-[(5-fluoro-1-pentyl-1H-indazol-3-yl)amino]pyridi...) Show SMILES CCCCCn1nc(Nc2cnccc2C(O)=O)c2cc(F)ccc12 Show InChI InChI=1S/C18H19FN4O2/c1-2-3-4-9-23-16-6-5-12(19)10-14(16)17(22-23)21-15-11-20-8-7-13(15)18(24)25/h5-8,10-11H,2-4,9H2,1H3,(H,21,22)(H,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
CELGENE QUANTICEL RESEARCH, INC. US Patent					Assay Description The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...				US Patent US9617242 (2017) BindingDB Entry DOI: 10.7270/Q2XK8HM5
					More data for this Ligand-Target Pair
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM277721 (3-[(5-fluoro-1-pentyl-1H-indazol-3-yl)amino]pyridi...) Show SMILES CCCCCn1nc(Nc2cnccc2C(O)=O)c2cc(F)ccc12 Show InChI InChI=1S/C18H19FN4O2/c1-2-3-4-9-23-16-6-5-12(19)10-14(16)17(22-23)21-15-11-20-8-7-13(15)18(24)25/h5-8,10-11H,2-4,9H2,1H3,(H,21,22)(H,24,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research Inc US Patent					Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...				US Patent US10336727 (2019) BindingDB Entry DOI: 10.7270/Q2571FBT
					More data for this Ligand-Target Pair
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM277721 (3-[(5-fluoro-1-pentyl-1H-indazol-3-yl)amino]pyridi...) Show SMILES CCCCCn1nc(Nc2cnccc2C(O)=O)c2cc(F)ccc12 Show InChI InChI=1S/C18H19FN4O2/c1-2-3-4-9-23-16-6-5-12(19)10-14(16)17(22-23)21-15-11-20-8-7-13(15)18(24)25/h5-8,10-11H,2-4,9H2,1H3,(H,21,22)(H,24,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
CELGENE QUANTICEL RESEARCH, INC. US Patent					Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...				US Patent US9617242 (2017) BindingDB Entry DOI: 10.7270/Q2XK8HM5
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5A (Homo sapiens (Human))	BDBM277721 (3-[(5-fluoro-1-pentyl-1H-indazol-3-yl)amino]pyridi...) Show SMILES CCCCCn1nc(Nc2cnccc2C(O)=O)c2cc(F)ccc12 Show InChI InChI=1S/C18H19FN4O2/c1-2-3-4-9-23-16-6-5-12(19)10-14(16)17(22-23)21-15-11-20-8-7-13(15)18(24)25/h5-8,10-11H,2-4,9H2,1H3,(H,21,22)(H,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research Inc US Patent					Assay Description The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...				US Patent US10336727 (2019) BindingDB Entry DOI: 10.7270/Q2571FBT
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5B (Homo sapiens (Human))	BDBM277721 (3-[(5-fluoro-1-pentyl-1H-indazol-3-yl)amino]pyridi...) Show SMILES CCCCCn1nc(Nc2cnccc2C(O)=O)c2cc(F)ccc12 Show InChI InChI=1S/C18H19FN4O2/c1-2-3-4-9-23-16-6-5-12(19)10-14(16)17(22-23)21-15-11-20-8-7-13(15)18(24)25/h5-8,10-11H,2-4,9H2,1H3,(H,21,22)(H,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research Inc US Patent					Assay Description The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...				US Patent US10336727 (2019) BindingDB Entry DOI: 10.7270/Q2571FBT
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5B (Homo sapiens (Human))	BDBM277721 (3-[(5-fluoro-1-pentyl-1H-indazol-3-yl)amino]pyridi...) Show SMILES CCCCCn1nc(Nc2cnccc2C(O)=O)c2cc(F)ccc12 Show InChI InChI=1S/C18H19FN4O2/c1-2-3-4-9-23-16-6-5-12(19)10-14(16)17(22-23)21-15-11-20-8-7-13(15)18(24)25/h5-8,10-11H,2-4,9H2,1H3,(H,21,22)(H,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
CELGENE QUANTICEL RESEARCH, INC. US Patent					Assay Description The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...				US Patent US9617242 (2017) BindingDB Entry DOI: 10.7270/Q2XK8HM5
					More data for this Ligand-Target Pair