BDBM277723 3-[(7-fluoro-1-propyl-1H-indazol-3-yl)amino]pyridine-4-carboxylic acid::US10040779, Example 20::US10336727, Example 20::US9617242, Example 20

SMILES: CCCn1nc(Nc2cnccc2C(O)=O)c2cccc(F)c12

InChI Key: InChIKey=LWBSTDMGDQNQBE-UHFFFAOYSA-N

Data: 9 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 277723   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Lysine-specific demethylase 5A (Homo sapiens (Human))	BDBM277723 (3-[(7-fluoro-1-propyl-1H-indazol-3-yl)amino]pyridi...) Show SMILES CCCn1nc(Nc2cnccc2C(O)=O)c2cccc(F)c12 Show InChI InChI=1S/C16H15FN4O2/c1-2-8-21-14-11(4-3-5-12(14)17)15(20-21)19-13-9-18-7-6-10(13)16(22)23/h3-7,9H,2,8H2,1H3,(H,19,20)(H,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.100	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...				US Patent US10040779 (2018) BindingDB Entry DOI: 10.7270/Q26H4KF1
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5B (Homo sapiens (Human))	BDBM277723 (3-[(7-fluoro-1-propyl-1H-indazol-3-yl)amino]pyridi...) Show SMILES CCCn1nc(Nc2cnccc2C(O)=O)c2cccc(F)c12 Show InChI InChI=1S/C16H15FN4O2/c1-2-8-21-14-11(4-3-5-12(14)17)15(20-21)19-13-9-18-7-6-10(13)16(22)23/h3-7,9H,2,8H2,1H3,(H,19,20)(H,22,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.100	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...				US Patent US10040779 (2018) BindingDB Entry DOI: 10.7270/Q26H4KF1
					More data for this Ligand-Target Pair
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM277723 (3-[(7-fluoro-1-propyl-1H-indazol-3-yl)amino]pyridi...) Show SMILES CCCn1nc(Nc2cnccc2C(O)=O)c2cccc(F)c12 Show InChI InChI=1S/C16H15FN4O2/c1-2-8-21-14-11(4-3-5-12(14)17)15(20-21)19-13-9-18-7-6-10(13)16(22)23/h3-7,9H,2,8H2,1H3,(H,19,20)(H,22,23)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.100	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...				US Patent US10040779 (2018) BindingDB Entry DOI: 10.7270/Q26H4KF1
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5A (Homo sapiens (Human))	BDBM277723 (3-[(7-fluoro-1-propyl-1H-indazol-3-yl)amino]pyridi...) Show SMILES CCCn1nc(Nc2cnccc2C(O)=O)c2cccc(F)c12 Show InChI InChI=1S/C16H15FN4O2/c1-2-8-21-14-11(4-3-5-12(14)17)15(20-21)19-13-9-18-7-6-10(13)16(22)23/h3-7,9H,2,8H2,1H3,(H,19,20)(H,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
CELGENE QUANTICEL RESEARCH, INC. US Patent					Assay Description The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...				US Patent US9617242 (2017) BindingDB Entry DOI: 10.7270/Q2XK8HM5
					More data for this Ligand-Target Pair
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM277723 (3-[(7-fluoro-1-propyl-1H-indazol-3-yl)amino]pyridi...) Show SMILES CCCn1nc(Nc2cnccc2C(O)=O)c2cccc(F)c12 Show InChI InChI=1S/C16H15FN4O2/c1-2-8-21-14-11(4-3-5-12(14)17)15(20-21)19-13-9-18-7-6-10(13)16(22)23/h3-7,9H,2,8H2,1H3,(H,19,20)(H,22,23)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research Inc US Patent					Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...				US Patent US10336727 (2019) BindingDB Entry DOI: 10.7270/Q2571FBT
					More data for this Ligand-Target Pair
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM277723 (3-[(7-fluoro-1-propyl-1H-indazol-3-yl)amino]pyridi...) Show SMILES CCCn1nc(Nc2cnccc2C(O)=O)c2cccc(F)c12 Show InChI InChI=1S/C16H15FN4O2/c1-2-8-21-14-11(4-3-5-12(14)17)15(20-21)19-13-9-18-7-6-10(13)16(22)23/h3-7,9H,2,8H2,1H3,(H,19,20)(H,22,23)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
CELGENE QUANTICEL RESEARCH, INC. US Patent					Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...				US Patent US9617242 (2017) BindingDB Entry DOI: 10.7270/Q2XK8HM5
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5A (Homo sapiens (Human))	BDBM277723 (3-[(7-fluoro-1-propyl-1H-indazol-3-yl)amino]pyridi...) Show SMILES CCCn1nc(Nc2cnccc2C(O)=O)c2cccc(F)c12 Show InChI InChI=1S/C16H15FN4O2/c1-2-8-21-14-11(4-3-5-12(14)17)15(20-21)19-13-9-18-7-6-10(13)16(22)23/h3-7,9H,2,8H2,1H3,(H,19,20)(H,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research Inc US Patent					Assay Description The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...				US Patent US10336727 (2019) BindingDB Entry DOI: 10.7270/Q2571FBT
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5B (Homo sapiens (Human))	BDBM277723 (3-[(7-fluoro-1-propyl-1H-indazol-3-yl)amino]pyridi...) Show SMILES CCCn1nc(Nc2cnccc2C(O)=O)c2cccc(F)c12 Show InChI InChI=1S/C16H15FN4O2/c1-2-8-21-14-11(4-3-5-12(14)17)15(20-21)19-13-9-18-7-6-10(13)16(22)23/h3-7,9H,2,8H2,1H3,(H,19,20)(H,22,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research Inc US Patent					Assay Description The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...				US Patent US10336727 (2019) BindingDB Entry DOI: 10.7270/Q2571FBT
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5B (Homo sapiens (Human))	BDBM277723 (3-[(7-fluoro-1-propyl-1H-indazol-3-yl)amino]pyridi...) Show SMILES CCCn1nc(Nc2cnccc2C(O)=O)c2cccc(F)c12 Show InChI InChI=1S/C16H15FN4O2/c1-2-8-21-14-11(4-3-5-12(14)17)15(20-21)19-13-9-18-7-6-10(13)16(22)23/h3-7,9H,2,8H2,1H3,(H,19,20)(H,22,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
CELGENE QUANTICEL RESEARCH, INC. US Patent					Assay Description The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...				US Patent US9617242 (2017) BindingDB Entry DOI: 10.7270/Q2XK8HM5
					More data for this Ligand-Target Pair