BDBM277731 3-{[1-(cyclobutylmethyl)-5-fluoro-1H-indazol-3-yl]amino}pyridine-4-carboxylic acid::US10040779, Example 28::US10336727, Example 28::US9617242, Example 28

SMILES: OC(=O)c1ccncc1Nc1nn(CC2CCC2)c2ccc(F)cc12

InChI Key: InChIKey=GBPMUZDFXMYGAC-UHFFFAOYSA-N

Data: 9 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 277731   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Lysine-specific demethylase 5A (Homo sapiens (Human))	BDBM277731 (3-{[1-(cyclobutylmethyl)-5-fluoro-1H-indazol-3-yl]...) Show SMILES OC(=O)c1ccncc1Nc1nn(CC2CCC2)c2ccc(F)cc12 Show InChI InChI=1S/C18H17FN4O2/c19-12-4-5-16-14(8-12)17(22-23(16)10-11-2-1-3-11)21-15-9-20-7-6-13(15)18(24)25/h4-9,11H,1-3,10H2,(H,21,22)(H,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.100	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...				US Patent US10040779 (2018) BindingDB Entry DOI: 10.7270/Q26H4KF1
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5B (Homo sapiens (Human))	BDBM277731 (3-{[1-(cyclobutylmethyl)-5-fluoro-1H-indazol-3-yl]...) Show SMILES OC(=O)c1ccncc1Nc1nn(CC2CCC2)c2ccc(F)cc12 Show InChI InChI=1S/C18H17FN4O2/c19-12-4-5-16-14(8-12)17(22-23(16)10-11-2-1-3-11)21-15-9-20-7-6-13(15)18(24)25/h4-9,11H,1-3,10H2,(H,21,22)(H,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.100	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...				US Patent US10040779 (2018) BindingDB Entry DOI: 10.7270/Q26H4KF1
					More data for this Ligand-Target Pair
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM277731 (3-{[1-(cyclobutylmethyl)-5-fluoro-1H-indazol-3-yl]...) Show SMILES OC(=O)c1ccncc1Nc1nn(CC2CCC2)c2ccc(F)cc12 Show InChI InChI=1S/C18H17FN4O2/c19-12-4-5-16-14(8-12)17(22-23(16)10-11-2-1-3-11)21-15-9-20-7-6-13(15)18(24)25/h4-9,11H,1-3,10H2,(H,21,22)(H,24,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.550	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...				US Patent US10040779 (2018) BindingDB Entry DOI: 10.7270/Q26H4KF1
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5A (Homo sapiens (Human))	BDBM277731 (3-{[1-(cyclobutylmethyl)-5-fluoro-1H-indazol-3-yl]...) Show SMILES OC(=O)c1ccncc1Nc1nn(CC2CCC2)c2ccc(F)cc12 Show InChI InChI=1S/C18H17FN4O2/c19-12-4-5-16-14(8-12)17(22-23(16)10-11-2-1-3-11)21-15-9-20-7-6-13(15)18(24)25/h4-9,11H,1-3,10H2,(H,21,22)(H,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
CELGENE QUANTICEL RESEARCH, INC. US Patent					Assay Description The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...				US Patent US9617242 (2017) BindingDB Entry DOI: 10.7270/Q2XK8HM5
					More data for this Ligand-Target Pair
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM277731 (3-{[1-(cyclobutylmethyl)-5-fluoro-1H-indazol-3-yl]...) Show SMILES OC(=O)c1ccncc1Nc1nn(CC2CCC2)c2ccc(F)cc12 Show InChI InChI=1S/C18H17FN4O2/c19-12-4-5-16-14(8-12)17(22-23(16)10-11-2-1-3-11)21-15-9-20-7-6-13(15)18(24)25/h4-9,11H,1-3,10H2,(H,21,22)(H,24,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research Inc US Patent					Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...				US Patent US10336727 (2019) BindingDB Entry DOI: 10.7270/Q2571FBT
					More data for this Ligand-Target Pair
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM277731 (3-{[1-(cyclobutylmethyl)-5-fluoro-1H-indazol-3-yl]...) Show SMILES OC(=O)c1ccncc1Nc1nn(CC2CCC2)c2ccc(F)cc12 Show InChI InChI=1S/C18H17FN4O2/c19-12-4-5-16-14(8-12)17(22-23(16)10-11-2-1-3-11)21-15-9-20-7-6-13(15)18(24)25/h4-9,11H,1-3,10H2,(H,21,22)(H,24,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
CELGENE QUANTICEL RESEARCH, INC. US Patent					Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...				US Patent US9617242 (2017) BindingDB Entry DOI: 10.7270/Q2XK8HM5
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5A (Homo sapiens (Human))	BDBM277731 (3-{[1-(cyclobutylmethyl)-5-fluoro-1H-indazol-3-yl]...) Show SMILES OC(=O)c1ccncc1Nc1nn(CC2CCC2)c2ccc(F)cc12 Show InChI InChI=1S/C18H17FN4O2/c19-12-4-5-16-14(8-12)17(22-23(16)10-11-2-1-3-11)21-15-9-20-7-6-13(15)18(24)25/h4-9,11H,1-3,10H2,(H,21,22)(H,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research Inc US Patent					Assay Description The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...				US Patent US10336727 (2019) BindingDB Entry DOI: 10.7270/Q2571FBT
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5B (Homo sapiens (Human))	BDBM277731 (3-{[1-(cyclobutylmethyl)-5-fluoro-1H-indazol-3-yl]...) Show SMILES OC(=O)c1ccncc1Nc1nn(CC2CCC2)c2ccc(F)cc12 Show InChI InChI=1S/C18H17FN4O2/c19-12-4-5-16-14(8-12)17(22-23(16)10-11-2-1-3-11)21-15-9-20-7-6-13(15)18(24)25/h4-9,11H,1-3,10H2,(H,21,22)(H,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research Inc US Patent					Assay Description The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...				US Patent US10336727 (2019) BindingDB Entry DOI: 10.7270/Q2571FBT
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5B (Homo sapiens (Human))	BDBM277731 (3-{[1-(cyclobutylmethyl)-5-fluoro-1H-indazol-3-yl]...) Show SMILES OC(=O)c1ccncc1Nc1nn(CC2CCC2)c2ccc(F)cc12 Show InChI InChI=1S/C18H17FN4O2/c19-12-4-5-16-14(8-12)17(22-23(16)10-11-2-1-3-11)21-15-9-20-7-6-13(15)18(24)25/h4-9,11H,1-3,10H2,(H,21,22)(H,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
CELGENE QUANTICEL RESEARCH, INC. US Patent					Assay Description The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...				US Patent US9617242 (2017) BindingDB Entry DOI: 10.7270/Q2XK8HM5
					More data for this Ligand-Target Pair