BDBM277733 3-{[1-(cyclopentylmethyl)-5-fluoro-1H-indazol-3-yl]amino}pyridine-4-carboxylic acid::US10040779, Example 30::US10336727, Example 30::US9617242, Example 30

SMILES: OC(=O)c1ccncc1Nc1nn(CC2CCCC2)c2ccc(F)cc12

InChI Key: InChIKey=ZIISMGYCXSHSOU-UHFFFAOYSA-N

Data: 9 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 277733   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Lysine-specific demethylase 5A (Homo sapiens (Human))	BDBM277733 (3-{[1-(cyclopentylmethyl)-5-fluoro-1H-indazol-3-yl...) Show SMILES OC(=O)c1ccncc1Nc1nn(CC2CCCC2)c2ccc(F)cc12 Show InChI InChI=1S/C19H19FN4O2/c20-13-5-6-17-15(9-13)18(23-24(17)11-12-3-1-2-4-12)22-16-10-21-8-7-14(16)19(25)26/h5-10,12H,1-4,11H2,(H,22,23)(H,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.100	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...				US Patent US10040779 (2018) BindingDB Entry DOI: 10.7270/Q26H4KF1
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5B (Homo sapiens (Human))	BDBM277733 (3-{[1-(cyclopentylmethyl)-5-fluoro-1H-indazol-3-yl...) Show SMILES OC(=O)c1ccncc1Nc1nn(CC2CCCC2)c2ccc(F)cc12 Show InChI InChI=1S/C19H19FN4O2/c20-13-5-6-17-15(9-13)18(23-24(17)11-12-3-1-2-4-12)22-16-10-21-8-7-14(16)19(25)26/h5-10,12H,1-4,11H2,(H,22,23)(H,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.100	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...				US Patent US10040779 (2018) BindingDB Entry DOI: 10.7270/Q26H4KF1
					More data for this Ligand-Target Pair
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM277733 (3-{[1-(cyclopentylmethyl)-5-fluoro-1H-indazol-3-yl...) Show SMILES OC(=O)c1ccncc1Nc1nn(CC2CCCC2)c2ccc(F)cc12 Show InChI InChI=1S/C19H19FN4O2/c20-13-5-6-17-15(9-13)18(23-24(17)11-12-3-1-2-4-12)22-16-10-21-8-7-14(16)19(25)26/h5-10,12H,1-4,11H2,(H,22,23)(H,25,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.550	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...				US Patent US10040779 (2018) BindingDB Entry DOI: 10.7270/Q26H4KF1
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5A (Homo sapiens (Human))	BDBM277733 (3-{[1-(cyclopentylmethyl)-5-fluoro-1H-indazol-3-yl...) Show SMILES OC(=O)c1ccncc1Nc1nn(CC2CCCC2)c2ccc(F)cc12 Show InChI InChI=1S/C19H19FN4O2/c20-13-5-6-17-15(9-13)18(23-24(17)11-12-3-1-2-4-12)22-16-10-21-8-7-14(16)19(25)26/h5-10,12H,1-4,11H2,(H,22,23)(H,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
CELGENE QUANTICEL RESEARCH, INC. US Patent					Assay Description The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...				US Patent US9617242 (2017) BindingDB Entry DOI: 10.7270/Q2XK8HM5
					More data for this Ligand-Target Pair
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM277733 (3-{[1-(cyclopentylmethyl)-5-fluoro-1H-indazol-3-yl...) Show SMILES OC(=O)c1ccncc1Nc1nn(CC2CCCC2)c2ccc(F)cc12 Show InChI InChI=1S/C19H19FN4O2/c20-13-5-6-17-15(9-13)18(23-24(17)11-12-3-1-2-4-12)22-16-10-21-8-7-14(16)19(25)26/h5-10,12H,1-4,11H2,(H,22,23)(H,25,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research Inc US Patent					Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...				US Patent US10336727 (2019) BindingDB Entry DOI: 10.7270/Q2571FBT
					More data for this Ligand-Target Pair
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM277733 (3-{[1-(cyclopentylmethyl)-5-fluoro-1H-indazol-3-yl...) Show SMILES OC(=O)c1ccncc1Nc1nn(CC2CCCC2)c2ccc(F)cc12 Show InChI InChI=1S/C19H19FN4O2/c20-13-5-6-17-15(9-13)18(23-24(17)11-12-3-1-2-4-12)22-16-10-21-8-7-14(16)19(25)26/h5-10,12H,1-4,11H2,(H,22,23)(H,25,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
CELGENE QUANTICEL RESEARCH, INC. US Patent					Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...				US Patent US9617242 (2017) BindingDB Entry DOI: 10.7270/Q2XK8HM5
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5A (Homo sapiens (Human))	BDBM277733 (3-{[1-(cyclopentylmethyl)-5-fluoro-1H-indazol-3-yl...) Show SMILES OC(=O)c1ccncc1Nc1nn(CC2CCCC2)c2ccc(F)cc12 Show InChI InChI=1S/C19H19FN4O2/c20-13-5-6-17-15(9-13)18(23-24(17)11-12-3-1-2-4-12)22-16-10-21-8-7-14(16)19(25)26/h5-10,12H,1-4,11H2,(H,22,23)(H,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research Inc US Patent					Assay Description The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...				US Patent US10336727 (2019) BindingDB Entry DOI: 10.7270/Q2571FBT
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5B (Homo sapiens (Human))	BDBM277733 (3-{[1-(cyclopentylmethyl)-5-fluoro-1H-indazol-3-yl...) Show SMILES OC(=O)c1ccncc1Nc1nn(CC2CCCC2)c2ccc(F)cc12 Show InChI InChI=1S/C19H19FN4O2/c20-13-5-6-17-15(9-13)18(23-24(17)11-12-3-1-2-4-12)22-16-10-21-8-7-14(16)19(25)26/h5-10,12H,1-4,11H2,(H,22,23)(H,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research Inc US Patent					Assay Description The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...				US Patent US10336727 (2019) BindingDB Entry DOI: 10.7270/Q2571FBT
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5B (Homo sapiens (Human))	BDBM277733 (3-{[1-(cyclopentylmethyl)-5-fluoro-1H-indazol-3-yl...) Show SMILES OC(=O)c1ccncc1Nc1nn(CC2CCCC2)c2ccc(F)cc12 Show InChI InChI=1S/C19H19FN4O2/c20-13-5-6-17-15(9-13)18(23-24(17)11-12-3-1-2-4-12)22-16-10-21-8-7-14(16)19(25)26/h5-10,12H,1-4,11H2,(H,22,23)(H,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
CELGENE QUANTICEL RESEARCH, INC. US Patent					Assay Description The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...				US Patent US9617242 (2017) BindingDB Entry DOI: 10.7270/Q2XK8HM5
					More data for this Ligand-Target Pair