null

SMILES: CN1CCOC(CCn2nc(Nc3cnccc3C(O)=O)c3cc(F)ccc23)C1

InChI Key: InChIKey=DNOHWOWSEKJTNK-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 277761   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Lysine-specific demethylase 5A (Homo sapiens (Human))	BDBM277761 (3-({5-fluoro-1-[2-(4-methylmorpholin-2-yl)ethyl]-1...) Show SMILES CN1CCOC(CCn2nc(Nc3cnccc3C(O)=O)c3cc(F)ccc23)C1 Show InChI InChI=1S/C20H22FN5O3/c1-25-8-9-29-14(12-25)5-7-26-18-3-2-13(21)10-16(18)19(24-26)23-17-11-22-6-4-15(17)20(27)28/h2-4,6,10-11,14H,5,7-9,12H2,1H3,(H,23,24)(H,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.100	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...				US Patent US10040779 (2018) BindingDB Entry DOI: 10.7270/Q26H4KF1
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5B (Homo sapiens (Human))	BDBM277761 (3-({5-fluoro-1-[2-(4-methylmorpholin-2-yl)ethyl]-1...) Show SMILES CN1CCOC(CCn2nc(Nc3cnccc3C(O)=O)c3cc(F)ccc23)C1 Show InChI InChI=1S/C20H22FN5O3/c1-25-8-9-29-14(12-25)5-7-26-18-3-2-13(21)10-16(18)19(24-26)23-17-11-22-6-4-15(17)20(27)28/h2-4,6,10-11,14H,5,7-9,12H2,1H3,(H,23,24)(H,27,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.100	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...				US Patent US10040779 (2018) BindingDB Entry DOI: 10.7270/Q26H4KF1
					More data for this Ligand-Target Pair
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM277761 (3-({5-fluoro-1-[2-(4-methylmorpholin-2-yl)ethyl]-1...) Show SMILES CN1CCOC(CCn2nc(Nc3cnccc3C(O)=O)c3cc(F)ccc23)C1 Show InChI InChI=1S/C20H22FN5O3/c1-25-8-9-29-14(12-25)5-7-26-18-3-2-13(21)10-16(18)19(24-26)23-17-11-22-6-4-15(17)20(27)28/h2-4,6,10-11,14H,5,7-9,12H2,1H3,(H,23,24)(H,27,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.100	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...				US Patent US10040779 (2018) BindingDB Entry DOI: 10.7270/Q26H4KF1
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5A (Homo sapiens (Human))	BDBM277761 (3-({5-fluoro-1-[2-(4-methylmorpholin-2-yl)ethyl]-1...) Show SMILES CN1CCOC(CCn2nc(Nc3cnccc3C(O)=O)c3cc(F)ccc23)C1 Show InChI InChI=1S/C20H22FN5O3/c1-25-8-9-29-14(12-25)5-7-26-18-3-2-13(21)10-16(18)19(24-26)23-17-11-22-6-4-15(17)20(27)28/h2-4,6,10-11,14H,5,7-9,12H2,1H3,(H,23,24)(H,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
CELGENE QUANTICEL RESEARCH, INC. US Patent					Assay Description The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...				US Patent US9617242 (2017) BindingDB Entry DOI: 10.7270/Q2XK8HM5
					More data for this Ligand-Target Pair
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM277761 (3-({5-fluoro-1-[2-(4-methylmorpholin-2-yl)ethyl]-1...) Show SMILES CN1CCOC(CCn2nc(Nc3cnccc3C(O)=O)c3cc(F)ccc23)C1 Show InChI InChI=1S/C20H22FN5O3/c1-25-8-9-29-14(12-25)5-7-26-18-3-2-13(21)10-16(18)19(24-26)23-17-11-22-6-4-15(17)20(27)28/h2-4,6,10-11,14H,5,7-9,12H2,1H3,(H,23,24)(H,27,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research Inc US Patent					Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...				US Patent US10336727 (2019) BindingDB Entry DOI: 10.7270/Q2571FBT
					More data for this Ligand-Target Pair
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM277761 (3-({5-fluoro-1-[2-(4-methylmorpholin-2-yl)ethyl]-1...) Show SMILES CN1CCOC(CCn2nc(Nc3cnccc3C(O)=O)c3cc(F)ccc23)C1 Show InChI InChI=1S/C20H22FN5O3/c1-25-8-9-29-14(12-25)5-7-26-18-3-2-13(21)10-16(18)19(24-26)23-17-11-22-6-4-15(17)20(27)28/h2-4,6,10-11,14H,5,7-9,12H2,1H3,(H,23,24)(H,27,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
CELGENE QUANTICEL RESEARCH, INC. US Patent					Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...				US Patent US9617242 (2017) BindingDB Entry DOI: 10.7270/Q2XK8HM5
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5A (Homo sapiens (Human))	BDBM277761 (3-({5-fluoro-1-[2-(4-methylmorpholin-2-yl)ethyl]-1...) Show SMILES CN1CCOC(CCn2nc(Nc3cnccc3C(O)=O)c3cc(F)ccc23)C1 Show InChI InChI=1S/C20H22FN5O3/c1-25-8-9-29-14(12-25)5-7-26-18-3-2-13(21)10-16(18)19(24-26)23-17-11-22-6-4-15(17)20(27)28/h2-4,6,10-11,14H,5,7-9,12H2,1H3,(H,23,24)(H,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research Inc US Patent					Assay Description The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...				US Patent US10336727 (2019) BindingDB Entry DOI: 10.7270/Q2571FBT
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5B (Homo sapiens (Human))	BDBM277761 (3-({5-fluoro-1-[2-(4-methylmorpholin-2-yl)ethyl]-1...) Show SMILES CN1CCOC(CCn2nc(Nc3cnccc3C(O)=O)c3cc(F)ccc23)C1 Show InChI InChI=1S/C20H22FN5O3/c1-25-8-9-29-14(12-25)5-7-26-18-3-2-13(21)10-16(18)19(24-26)23-17-11-22-6-4-15(17)20(27)28/h2-4,6,10-11,14H,5,7-9,12H2,1H3,(H,23,24)(H,27,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research Inc US Patent					Assay Description The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...				US Patent US10336727 (2019) BindingDB Entry DOI: 10.7270/Q2571FBT
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5B (Homo sapiens (Human))	BDBM277761 (3-({5-fluoro-1-[2-(4-methylmorpholin-2-yl)ethyl]-1...) Show SMILES CN1CCOC(CCn2nc(Nc3cnccc3C(O)=O)c3cc(F)ccc23)C1 Show InChI InChI=1S/C20H22FN5O3/c1-25-8-9-29-14(12-25)5-7-26-18-3-2-13(21)10-16(18)19(24-26)23-17-11-22-6-4-15(17)20(27)28/h2-4,6,10-11,14H,5,7-9,12H2,1H3,(H,23,24)(H,27,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
CELGENE QUANTICEL RESEARCH, INC. US Patent					Assay Description The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...				US Patent US9617242 (2017) BindingDB Entry DOI: 10.7270/Q2XK8HM5
					More data for this Ligand-Target Pair