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BDBM27827 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine, 10::4-fluoro-2-[(2-{[2-methoxy-4-(4-propylpiperazin-1-yl)phenyl]amino}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]benzamide

SMILES: CCCN1CCN(CC1)c1ccc(Nc2nc(Nc3cc(F)ccc3C(N)=O)c3cc[nH]c3n2)c(OC)c1

InChI Key: InChIKey=WDQRIUWJCINPFK-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 27827   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM27827
PNG
(4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine, 10 | ...)
Show SMILES CCCN1CCN(CC1)c1ccc(Nc2nc(Nc3cc(F)ccc3C(N)=O)c3cc[nH]c3n2)c(OC)c1
Show InChI InChI=1S/C27H31FN8O2/c1-3-10-35-11-13-36(14-12-35)18-5-7-21(23(16-18)38-2)32-27-33-25-20(8-9-30-25)26(34-27)31-22-15-17(28)4-6-19(22)24(29)37/h4-9,15-16H,3,10-14H2,1-2H3,(H2,29,37)(H3,30,31,32,33,34)
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MMDB

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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.60n/an/an/an/a7.522



GSK



Assay Description
Assays are performed in 384-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified activated GST-IGF-1R in th...


Bioorg Med Chem Lett 19: 469-73 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.046
BindingDB Entry DOI: 10.7270/Q2J67F88
More data for this
Ligand-Target Pair