BDBM27848 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine, 34::5-fluoro-2-{[2-({2-methoxy-4-[4-(propan-2-yl)piperazin-1-yl]phenyl}amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}-N-(2-methoxyethyl)benzamide

SMILES: COCCNC(=O)c1cc(F)ccc1Nc1nc(Nc2ccc(cc2OC)N2CCN(CC2)C(C)C)nc2[nH]ccc12

InChI Key: InChIKey=ASNDXJNBHVPPGQ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 27848   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Insulin-like growth factor I receptor (Homo sapiens (Human))	BDBM27848 (4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine, 34 | ...) Show SMILES COCCNC(=O)c1cc(F)ccc1Nc1nc(Nc2ccc(cc2OC)N2CCN(CC2)C(C)C)nc2[nH]ccc12 Show InChI InChI=1S/C30H37FN8O3/c1-19(2)38-12-14-39(15-13-38)21-6-8-25(26(18-21)42-4)35-30-36-27-22(9-10-32-27)28(37-30)34-24-7-5-20(31)17-23(24)29(40)33-11-16-41-3/h5-10,17-19H,11-16H2,1-4H3,(H,33,40)(H3,32,34,35,36,37)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description Assays are performed in 384-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified activated GST-IGF-1R in th...				Bioorg Med Chem Lett 19: 469-73 (2009) Article DOI: 10.1016/j.bmcl.2008.11.046 BindingDB Entry DOI: 10.7270/Q2J67F88
					More data for this Ligand-Target Pair