BDBM278722 2-{[(1R,2S)-2- aminocyclo- hexyl]amino}-N-[3- (difluoromethyl)-1- methyl-1H-pyrazol-4- yl]pyrrolo[1,2- b]pyridazine-7- carboxamide trifluoroacetate::US10040798, Example 19
SMILES: OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2ccc3ccc(N[C@@H]4CCCC[C@@H]4N)nn23)c(n1)C(F)F
InChI Key: InChIKey=WNEGSSZSBWEIPF-JHEYCYPBSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Interleukin-1 receptor-associated kinase 4 (Homo sapiens (Human)) | BDBM278722 (2-{[(1R,2S)-2- aminocyclo- hexyl]amino}-N-[3- (dif...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | 7.2 | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp... | US Patent US10040798 (2018) BindingDB Entry DOI: 10.7270/Q2F191Q7 | |||||||||||
More data for this Ligand-Target Pair |