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SMILES: Cn1cc(NC(=O)c2csc3ncc(N[C@@H]4CCCC[C@@H]4O)nc23)c(n1)C(F)F

InChI Key: InChIKey=ICHDHJVZCACABZ-PWSUYJOCSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 278831   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM278831
PNG
(N-[3-(difluoromethyl)- 1-methyl-1H-pyrazol- 4-yl]-...)
Show SMILES Cn1cc(NC(=O)c2csc3ncc(N[C@@H]4CCCC[C@@H]4O)nc23)c(n1)C(F)F |r|
Show InChI InChI=1S/C18H20F2N6O2S/c1-26-7-11(15(25-26)16(19)20)23-17(28)9-8-29-18-14(9)24-13(6-21-18)22-10-4-2-3-5-12(10)27/h6-8,10,12,16,27H,2-5H2,1H3,(H,22,24)(H,23,28)/t10-,12+/m1/s1
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PC cid
PC sid
UniChem
US Patent
n/an/a 30n/an/an/an/a7.2n/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...

US Patent US10040802 (2018)


BindingDB Entry DOI: 10.7270/Q298891C
More data for this
Ligand-Target Pair