BDBM278835 2-(1,4-diazepan-1-yl)- N-[3-(difluoromethyl)- 1-methyl-1H-pyrazol- 4-yl]thieno[2,3-b] pyrazine-7- carboxamide trifluoroacetate::US10040802, Example 14

SMILES: OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2csc3ncc(nc23)N2CCCNCC2)c(n1)C(F)F

InChI Key: InChIKey=UEDORIDQLYBLGP-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 278835   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Interleukin-1 receptor-associated kinase 4 (Homo sapiens (Human))	BDBM278835 (2-(1,4-diazepan-1-yl)- N-[3-(difluoromethyl)- 1-me...) Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2csc3ncc(nc23)N2CCCNCC2)c(n1)C(F)F Show InChI InChI=1S/C17H19F2N7OS/c1-25-8-11(14(24-25)15(18)19)22-16(27)10-9-28-17-13(10)23-12(7-21-17)26-5-2-3-20-4-6-26/h7-9,15,20H,2-6H2,1H3,(H,22,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	7.2	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...				US Patent US10040802 (2018) BindingDB Entry DOI: 10.7270/Q298891C
					More data for this Ligand-Target Pair