BDBM278863 2-{[(1R,2S)-2- aminocyclohexyl]amino}- N-(1-methyl-5- (trifluoromethyl)-1H- pyrazol-4- yl]thieno[2,3-b] pyrazine-7- carboxamide trifluoroacetate::US10040802, Example 42
SMILES: OC(=O)C(F)(F)F.C[N]1=C(C(NC(=O)c2csc3ncc(N[C@@H]4CCCC[C@@H]4N)nc23)=CN1)C(F)(F)F
InChI Key: InChIKey=OIAUWHPYXMWGKA-VZXYPILPSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Interleukin-1 receptor-associated kinase 4 (Homo sapiens (Human)) | BDBM278863 (2-{[(1R,2S)-2- aminocyclohexyl]amino}- N-(1-methyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 16 | n/a | n/a | n/a | n/a | 7.2 | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp... | US Patent US10040802 (2018) BindingDB Entry DOI: 10.7270/Q298891C | |||||||||||
More data for this Ligand-Target Pair |