BDBM278914 2-[(3S)- or (3R)- azepan-3- ylamino]-N-(2- cyanophenyl)- thieno[2,3-b]- pyrazine-7- carboxamide trifluoroacetate::US10040802, Example 94
SMILES: OC(=O)C(F)(F)F.O=C(Nc1ccccc1C#N)c1csc2ncc(N[C@@H]3CCCCNC3)nc12
InChI Key: InChIKey=KEILVEJHAHKBIS-PFEQFJNWSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Interleukin-1 receptor-associated kinase 4 (Homo sapiens (Human)) | BDBM278914 (2-[(3S)- or (3R)- azepan-3- ylamino]-N-(2- cyanoph...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 9 | n/a | n/a | n/a | n/a | 7.2 | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp... | US Patent US10040802 (2018) BindingDB Entry DOI: 10.7270/Q298891C | |||||||||||
More data for this Ligand-Target Pair |