BDBM279024 N-[(1,5-dimethylpyrazol-3-yl)methyl]-5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 54::US10512632, Example 54::US10806718, Example 54
SMILES: CCOc1ncccc1-c1cc(NCc2cc(C)n(C)n2)c2n(nc(C)c2n1)C(C)C
InChI Key: InChIKey=LOSBPLVFUGTAOA-UHFFFAOYSA-N
Data: 12 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (Homo sapiens (Human)) | BDBM279024 (N-[(1,5-dimethylpyrazol-3-yl)methyl]-5-(2-ethoxy-3...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.390 | n/a | n/a | n/a | n/a | 7.6 | 25 |
H. Lundbeck A/S US Patent | Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ... | US Patent US10034861 (2018) BindingDB Entry DOI: 10.7270/Q2X350HN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase, PDE1/PDE5 (Homo sapiens (Human)) | BDBM279024 (N-[(1,5-dimethylpyrazol-3-yl)methyl]-5-(2-ethoxy-3...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.180 | n/a | n/a | n/a | n/a | 7.6 | 25 |
H. Lundbeck A/S US Patent | Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ... | US Patent US10034861 (2018) BindingDB Entry DOI: 10.7270/Q2X350HN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (Homo sapiens (Human)) | BDBM279024 (N-[(1,5-dimethylpyrazol-3-yl)methyl]-5-(2-ethoxy-3...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.60 | n/a | n/a | n/a | n/a | 7.6 | 25 |
H. Lundbeck A/S US Patent | Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ... | US Patent US10034861 (2018) BindingDB Entry DOI: 10.7270/Q2X350HN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Calcium/calmodulin-dependent 3',5'-cyclic phosphodiesterase 1A (Homo sapiens (Human)) | BDBM279024 (N-[(1,5-dimethylpyrazol-3-yl)methyl]-5-(2-ethoxy-3...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.390 | n/a | n/a | n/a | n/a | n/a | n/a |
H. Lundbeck A/S US Patent | Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ... | US Patent US10512632 (2019) BindingDB Entry DOI: 10.7270/Q25T3NVN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human)) | BDBM279024 (N-[(1,5-dimethylpyrazol-3-yl)methyl]-5-(2-ethoxy-3...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.180 | n/a | n/a | n/a | n/a | n/a | n/a |
H. Lundbeck A/S US Patent | Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ... | US Patent US10512632 (2019) BindingDB Entry DOI: 10.7270/Q25T3NVN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (Homo sapiens (Human)) | BDBM279024 (N-[(1,5-dimethylpyrazol-3-yl)methyl]-5-(2-ethoxy-3...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.60 | n/a | n/a | n/a | n/a | n/a | n/a |
H. Lundbeck A/S US Patent | Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff... | US Patent US11026923 (2021) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Calcium/calmodulin-dependent 3',5'-cyclic phosphodiesterase 1A (Homo sapiens (Human)) | BDBM279024 (N-[(1,5-dimethylpyrazol-3-yl)methyl]-5-(2-ethoxy-3...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.390 | n/a | n/a | n/a | n/a | n/a | n/a |
H. Lundbeck A/S US Patent | Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ... | US Patent US10806718 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human)) | BDBM279024 (N-[(1,5-dimethylpyrazol-3-yl)methyl]-5-(2-ethoxy-3...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.180 | n/a | n/a | n/a | n/a | n/a | n/a |
H. Lundbeck A/S US Patent | Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ... | US Patent US10806718 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (Homo sapiens (Human)) | BDBM279024 (N-[(1,5-dimethylpyrazol-3-yl)methyl]-5-(2-ethoxy-3...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.60 | n/a | n/a | n/a | n/a | n/a | n/a |
H. Lundbeck A/S US Patent | Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ... | US Patent US10806718 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Calcium/calmodulin-dependent 3',5'-cyclic phosphodiesterase 1A (Homo sapiens (Human)) | BDBM279024 (N-[(1,5-dimethylpyrazol-3-yl)methyl]-5-(2-ethoxy-3...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.390 | n/a | n/a | n/a | n/a | n/a | n/a |
H. Lundbeck A/S US Patent | Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff... | US Patent US11026923 (2021) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human)) | BDBM279024 (N-[(1,5-dimethylpyrazol-3-yl)methyl]-5-(2-ethoxy-3...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.180 | n/a | n/a | n/a | n/a | n/a | n/a |
H. Lundbeck A/S US Patent | Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff... | US Patent US11026923 (2021) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (Homo sapiens (Human)) | BDBM279024 (N-[(1,5-dimethylpyrazol-3-yl)methyl]-5-(2-ethoxy-3...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.60 | n/a | n/a | n/a | n/a | n/a | n/a |
H. Lundbeck A/S US Patent | Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ... | US Patent US10512632 (2019) BindingDB Entry DOI: 10.7270/Q25T3NVN | |||||||||||
More data for this Ligand-Target Pair |