BDBM279047 5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[[2-(trifluoromethyl)-3-pyridyl]methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 77::US10512632, Example 77::US10766893, Example S77::US10806718, Example 77

SMILES: CCOc1ncccc1-c1cc(NCc2cccnc2C(F)(F)F)c2n(nc(C)c2n1)C(C)C

InChI Key: InChIKey=TZBBGNNWRKPAEH-UHFFFAOYSA-N

Data: 15 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 279047   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (Homo sapiens (Human))	BDBM279047 (5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[[2-...) Show SMILES CCOc1ncccc1-c1cc(NCc2cccnc2C(F)(F)F)c2n(nc(C)c2n1)C(C)C Show InChI InChI=1S/C24H25F3N6O/c1-5-34-23-17(9-7-11-29-23)18-12-19(21-20(31-18)15(4)32-33(21)14(2)3)30-13-16-8-6-10-28-22(16)24(25,26)27/h6-12,14H,5,13H2,1-4H3,(H,30,31)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	21	n/a	n/a	n/a	n/a	7.6	25
H. Lundbeck A/S US Patent					Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...				US Patent US10034861 (2018) BindingDB Entry DOI: 10.7270/Q2X350HN
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (Homo sapiens (Human))	BDBM279047 (5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[[2-...) Show SMILES CCOc1ncccc1-c1cc(NCc2cccnc2C(F)(F)F)c2n(nc(C)c2n1)C(C)C Show InChI InChI=1S/C24H25F3N6O/c1-5-34-23-17(9-7-11-29-23)18-12-19(21-20(31-18)15(4)32-33(21)14(2)3)30-13-16-8-6-10-28-22(16)24(25,26)27/h6-12,14H,5,13H2,1-4H3,(H,30,31)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	64	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...				US Patent US11026923 (2021)
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (Homo sapiens (Human))	BDBM279047 (5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[[2-...) Show SMILES CCOc1ncccc1-c1cc(NCc2cccnc2C(F)(F)F)c2n(nc(C)c2n1)C(C)C Show InChI InChI=1S/C24H25F3N6O/c1-5-34-23-17(9-7-11-29-23)18-12-19(21-20(31-18)15(4)32-33(21)14(2)3)30-13-16-8-6-10-28-22(16)24(25,26)27/h6-12,14H,5,13H2,1-4H3,(H,30,31)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	64	n/a	n/a	n/a	n/a	7.6	25
H. Lundbeck A/S US Patent					Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...				US Patent US10034861 (2018) BindingDB Entry DOI: 10.7270/Q2X350HN
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic phosphodiesterase 1A (Homo sapiens (Human))	BDBM279047 (5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[[2-...) Show SMILES CCOc1ncccc1-c1cc(NCc2cccnc2C(F)(F)F)c2n(nc(C)c2n1)C(C)C Show InChI InChI=1S/C24H25F3N6O/c1-5-34-23-17(9-7-11-29-23)18-12-19(21-20(31-18)15(4)32-33(21)14(2)3)30-13-16-8-6-10-28-22(16)24(25,26)27/h6-12,14H,5,13H2,1-4H3,(H,30,31)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...				US Patent US10512632 (2019) BindingDB Entry DOI: 10.7270/Q25T3NVN
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM279047 (5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[[2-...) Show SMILES CCOc1ncccc1-c1cc(NCc2cccnc2C(F)(F)F)c2n(nc(C)c2n1)C(C)C Show InChI InChI=1S/C24H25F3N6O/c1-5-34-23-17(9-7-11-29-23)18-12-19(21-20(31-18)15(4)32-33(21)14(2)3)30-13-16-8-6-10-28-22(16)24(25,26)27/h6-12,14H,5,13H2,1-4H3,(H,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.220	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...				US Patent US10512632 (2019) BindingDB Entry DOI: 10.7270/Q25T3NVN
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (Homo sapiens (Human))	BDBM279047 (5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[[2-...) Show SMILES CCOc1ncccc1-c1cc(NCc2cccnc2C(F)(F)F)c2n(nc(C)c2n1)C(C)C Show InChI InChI=1S/C24H25F3N6O/c1-5-34-23-17(9-7-11-29-23)18-12-19(21-20(31-18)15(4)32-33(21)14(2)3)30-13-16-8-6-10-28-22(16)24(25,26)27/h6-12,14H,5,13H2,1-4H3,(H,30,31)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	64	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...				US Patent US10512632 (2019) BindingDB Entry DOI: 10.7270/Q25T3NVN
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic phosphodiesterase 1A (Homo sapiens (Human))	BDBM279047 (5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[[2-...) Show SMILES CCOc1ncccc1-c1cc(NCc2cccnc2C(F)(F)F)c2n(nc(C)c2n1)C(C)C Show InChI InChI=1S/C24H25F3N6O/c1-5-34-23-17(9-7-11-29-23)18-12-19(21-20(31-18)15(4)32-33(21)14(2)3)30-13-16-8-6-10-28-22(16)24(25,26)27/h6-12,14H,5,13H2,1-4H3,(H,30,31)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...				US Patent US10766893 (2020)
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM279047 (5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[[2-...) Show SMILES CCOc1ncccc1-c1cc(NCc2cccnc2C(F)(F)F)c2n(nc(C)c2n1)C(C)C Show InChI InChI=1S/C24H25F3N6O/c1-5-34-23-17(9-7-11-29-23)18-12-19(21-20(31-18)15(4)32-33(21)14(2)3)30-13-16-8-6-10-28-22(16)24(25,26)27/h6-12,14H,5,13H2,1-4H3,(H,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.220	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...				US Patent US10766893 (2020)
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (Homo sapiens (Human))	BDBM279047 (5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[[2-...) Show SMILES CCOc1ncccc1-c1cc(NCc2cccnc2C(F)(F)F)c2n(nc(C)c2n1)C(C)C Show InChI InChI=1S/C24H25F3N6O/c1-5-34-23-17(9-7-11-29-23)18-12-19(21-20(31-18)15(4)32-33(21)14(2)3)30-13-16-8-6-10-28-22(16)24(25,26)27/h6-12,14H,5,13H2,1-4H3,(H,30,31)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	64	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...				US Patent US10766893 (2020)
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic phosphodiesterase 1A (Homo sapiens (Human))	BDBM279047 (5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[[2-...) Show SMILES CCOc1ncccc1-c1cc(NCc2cccnc2C(F)(F)F)c2n(nc(C)c2n1)C(C)C Show InChI InChI=1S/C24H25F3N6O/c1-5-34-23-17(9-7-11-29-23)18-12-19(21-20(31-18)15(4)32-33(21)14(2)3)30-13-16-8-6-10-28-22(16)24(25,26)27/h6-12,14H,5,13H2,1-4H3,(H,30,31)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...				US Patent US10806718 (2020)
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM279047 (5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[[2-...) Show SMILES CCOc1ncccc1-c1cc(NCc2cccnc2C(F)(F)F)c2n(nc(C)c2n1)C(C)C Show InChI InChI=1S/C24H25F3N6O/c1-5-34-23-17(9-7-11-29-23)18-12-19(21-20(31-18)15(4)32-33(21)14(2)3)30-13-16-8-6-10-28-22(16)24(25,26)27/h6-12,14H,5,13H2,1-4H3,(H,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.220	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...				US Patent US10806718 (2020)
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (Homo sapiens (Human))	BDBM279047 (5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[[2-...) Show SMILES CCOc1ncccc1-c1cc(NCc2cccnc2C(F)(F)F)c2n(nc(C)c2n1)C(C)C Show InChI InChI=1S/C24H25F3N6O/c1-5-34-23-17(9-7-11-29-23)18-12-19(21-20(31-18)15(4)32-33(21)14(2)3)30-13-16-8-6-10-28-22(16)24(25,26)27/h6-12,14H,5,13H2,1-4H3,(H,30,31)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	64	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...				US Patent US10806718 (2020)
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic phosphodiesterase 1A (Homo sapiens (Human))	BDBM279047 (5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[[2-...) Show SMILES CCOc1ncccc1-c1cc(NCc2cccnc2C(F)(F)F)c2n(nc(C)c2n1)C(C)C Show InChI InChI=1S/C24H25F3N6O/c1-5-34-23-17(9-7-11-29-23)18-12-19(21-20(31-18)15(4)32-33(21)14(2)3)30-13-16-8-6-10-28-22(16)24(25,26)27/h6-12,14H,5,13H2,1-4H3,(H,30,31)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...				US Patent US11026923 (2021)
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM279047 (5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[[2-...) Show SMILES CCOc1ncccc1-c1cc(NCc2cccnc2C(F)(F)F)c2n(nc(C)c2n1)C(C)C Show InChI InChI=1S/C24H25F3N6O/c1-5-34-23-17(9-7-11-29-23)18-12-19(21-20(31-18)15(4)32-33(21)14(2)3)30-13-16-8-6-10-28-22(16)24(25,26)27/h6-12,14H,5,13H2,1-4H3,(H,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.220	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...				US Patent US11026923 (2021)
					More data for this Ligand-Target Pair
Phosphodiesterase, PDE1/PDE5 (Homo sapiens (Human))	BDBM279047 (5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[[2-...) Show SMILES CCOc1ncccc1-c1cc(NCc2cccnc2C(F)(F)F)c2n(nc(C)c2n1)C(C)C Show InChI InChI=1S/C24H25F3N6O/c1-5-34-23-17(9-7-11-29-23)18-12-19(21-20(31-18)15(4)32-33(21)14(2)3)30-13-16-8-6-10-28-22(16)24(25,26)27/h6-12,14H,5,13H2,1-4H3,(H,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.220	n/a	n/a	n/a	n/a	7.6	25
H. Lundbeck A/S US Patent					Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...				US Patent US10034861 (2018) BindingDB Entry DOI: 10.7270/Q2X350HN
					More data for this Ligand-Target Pair