BDBM279096 5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]-N-[(2-methyltetrazol-5-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 127::US10512632, Example 127::US10766893, Example S127::US10806718, Example 127

SMILES: CCOc1ncccc1-c1cc(NCc2nnn(C)n2)c2n(nc(C)c2n1)C(C)CC

InChI Key: InChIKey=ULBLNKNNIPTFLN-UHFFFAOYSA-N

Data: 12 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 279096   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (Homo sapiens (Human))	BDBM279096 (5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...) Show SMILES CCOc1ncccc1-c1cc(NCc2nnn(C)n2)c2n(nc(C)c2n1)C(C)CC Show InChI InChI=1S/C21H27N9O/c1-6-13(3)30-20-17(23-12-18-25-28-29(5)27-18)11-16(24-19(20)14(4)26-30)15-9-8-10-22-21(15)31-7-2/h8-11,13H,6-7,12H2,1-5H3,(H,23,24)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	7.6	25
H. Lundbeck A/S US Patent					Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...				US Patent US10034861 (2018) BindingDB Entry DOI: 10.7270/Q2X350HN
					More data for this Ligand-Target Pair
Phosphodiesterase, PDE1/PDE5 (Homo sapiens (Human))	BDBM279096 (5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...) Show SMILES CCOc1ncccc1-c1cc(NCc2nnn(C)n2)c2n(nc(C)c2n1)C(C)CC Show InChI InChI=1S/C21H27N9O/c1-6-13(3)30-20-17(23-12-18-25-28-29(5)27-18)11-16(24-19(20)14(4)26-30)15-9-8-10-22-21(15)31-7-2/h8-11,13H,6-7,12H2,1-5H3,(H,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.310	n/a	n/a	n/a	n/a	7.6	25
H. Lundbeck A/S US Patent					Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...				US Patent US10034861 (2018) BindingDB Entry DOI: 10.7270/Q2X350HN
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (Homo sapiens (Human))	BDBM279096 (5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...) Show SMILES CCOc1ncccc1-c1cc(NCc2nnn(C)n2)c2n(nc(C)c2n1)C(C)CC Show InChI InChI=1S/C21H27N9O/c1-6-13(3)30-20-17(23-12-18-25-28-29(5)27-18)11-16(24-19(20)14(4)26-30)15-9-8-10-22-21(15)31-7-2/h8-11,13H,6-7,12H2,1-5H3,(H,23,24)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.10	n/a	n/a	n/a	n/a	7.6	25
H. Lundbeck A/S US Patent					Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...				US Patent US10034861 (2018) BindingDB Entry DOI: 10.7270/Q2X350HN
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic phosphodiesterase 1A (Homo sapiens (Human))	BDBM279096 (5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...) Show SMILES CCOc1ncccc1-c1cc(NCc2nnn(C)n2)c2n(nc(C)c2n1)C(C)CC Show InChI InChI=1S/C21H27N9O/c1-6-13(3)30-20-17(23-12-18-25-28-29(5)27-18)11-16(24-19(20)14(4)26-30)15-9-8-10-22-21(15)31-7-2/h8-11,13H,6-7,12H2,1-5H3,(H,23,24)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...				US Patent US10512632 (2019) BindingDB Entry DOI: 10.7270/Q25T3NVN
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM279096 (5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...) Show SMILES CCOc1ncccc1-c1cc(NCc2nnn(C)n2)c2n(nc(C)c2n1)C(C)CC Show InChI InChI=1S/C21H27N9O/c1-6-13(3)30-20-17(23-12-18-25-28-29(5)27-18)11-16(24-19(20)14(4)26-30)15-9-8-10-22-21(15)31-7-2/h8-11,13H,6-7,12H2,1-5H3,(H,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.310	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...				US Patent US10512632 (2019) BindingDB Entry DOI: 10.7270/Q25T3NVN
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (Homo sapiens (Human))	BDBM279096 (5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...) Show SMILES CCOc1ncccc1-c1cc(NCc2nnn(C)n2)c2n(nc(C)c2n1)C(C)CC Show InChI InChI=1S/C21H27N9O/c1-6-13(3)30-20-17(23-12-18-25-28-29(5)27-18)11-16(24-19(20)14(4)26-30)15-9-8-10-22-21(15)31-7-2/h8-11,13H,6-7,12H2,1-5H3,(H,23,24)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.10	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...				US Patent US10806718 (2020)
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic phosphodiesterase 1A (Homo sapiens (Human))	BDBM279096 (5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...) Show SMILES CCOc1ncccc1-c1cc(NCc2nnn(C)n2)c2n(nc(C)c2n1)C(C)CC Show InChI InChI=1S/C21H27N9O/c1-6-13(3)30-20-17(23-12-18-25-28-29(5)27-18)11-16(24-19(20)14(4)26-30)15-9-8-10-22-21(15)31-7-2/h8-11,13H,6-7,12H2,1-5H3,(H,23,24)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...				US Patent US10766893 (2020)
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM279096 (5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...) Show SMILES CCOc1ncccc1-c1cc(NCc2nnn(C)n2)c2n(nc(C)c2n1)C(C)CC Show InChI InChI=1S/C21H27N9O/c1-6-13(3)30-20-17(23-12-18-25-28-29(5)27-18)11-16(24-19(20)14(4)26-30)15-9-8-10-22-21(15)31-7-2/h8-11,13H,6-7,12H2,1-5H3,(H,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.310	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...				US Patent US10766893 (2020)
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (Homo sapiens (Human))	BDBM279096 (5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...) Show SMILES CCOc1ncccc1-c1cc(NCc2nnn(C)n2)c2n(nc(C)c2n1)C(C)CC Show InChI InChI=1S/C21H27N9O/c1-6-13(3)30-20-17(23-12-18-25-28-29(5)27-18)11-16(24-19(20)14(4)26-30)15-9-8-10-22-21(15)31-7-2/h8-11,13H,6-7,12H2,1-5H3,(H,23,24)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.10	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...				US Patent US10766893 (2020)
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic phosphodiesterase 1A (Homo sapiens (Human))	BDBM279096 (5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...) Show SMILES CCOc1ncccc1-c1cc(NCc2nnn(C)n2)c2n(nc(C)c2n1)C(C)CC Show InChI InChI=1S/C21H27N9O/c1-6-13(3)30-20-17(23-12-18-25-28-29(5)27-18)11-16(24-19(20)14(4)26-30)15-9-8-10-22-21(15)31-7-2/h8-11,13H,6-7,12H2,1-5H3,(H,23,24)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...				US Patent US10806718 (2020)
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM279096 (5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...) Show SMILES CCOc1ncccc1-c1cc(NCc2nnn(C)n2)c2n(nc(C)c2n1)C(C)CC Show InChI InChI=1S/C21H27N9O/c1-6-13(3)30-20-17(23-12-18-25-28-29(5)27-18)11-16(24-19(20)14(4)26-30)15-9-8-10-22-21(15)31-7-2/h8-11,13H,6-7,12H2,1-5H3,(H,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.310	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...				US Patent US10806718 (2020)
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (Homo sapiens (Human))	BDBM279096 (5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...) Show SMILES CCOc1ncccc1-c1cc(NCc2nnn(C)n2)c2n(nc(C)c2n1)C(C)CC Show InChI InChI=1S/C21H27N9O/c1-6-13(3)30-20-17(23-12-18-25-28-29(5)27-18)11-16(24-19(20)14(4)26-30)15-9-8-10-22-21(15)31-7-2/h8-11,13H,6-7,12H2,1-5H3,(H,23,24)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.10	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...				US Patent US10512632 (2019) BindingDB Entry DOI: 10.7270/Q25T3NVN
					More data for this Ligand-Target Pair