BDBM279103 3-methyl-1-[1-methylpropyl]-N-[(1-methyl-1,2,4-triazol-3-yl)methyl]-5-(2-propoxy-3-pyridyl)pyrazolo[4,3-b]pyridin-7-amine,enantiomer 2::US10034861, Example 134::US10512632, Example 134::US10766893, Example S134::US10806718, Example 134

SMILES: CCCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(nc(C)c2n1)C(C)CC

InChI Key: InChIKey=SXNFSKBWTTYFLI-UHFFFAOYSA-N

Data: 12 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 279103   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (Homo sapiens (Human))	BDBM279103 (3-methyl-1-[1-methylpropyl]-N-[(1-methyl-1,2,4-tri...) Show SMILES CCCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(nc(C)c2n1)C(C)CC Show InChI InChI=1S/C23H30N8O/c1-6-11-32-23-17(9-8-10-24-23)18-12-19(25-13-20-26-14-30(5)29-20)22-21(27-18)16(4)28-31(22)15(3)7-2/h8-10,12,14-15H,6-7,11,13H2,1-5H3,(H,25,27)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.960	n/a	n/a	n/a	n/a	7.6	25
H. Lundbeck A/S US Patent					Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...				US Patent US10034861 (2018) BindingDB Entry DOI: 10.7270/Q2X350HN
					More data for this Ligand-Target Pair
Phosphodiesterase, PDE1/PDE5 (Homo sapiens (Human))	BDBM279103 (3-methyl-1-[1-methylpropyl]-N-[(1-methyl-1,2,4-tri...) Show SMILES CCCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(nc(C)c2n1)C(C)CC Show InChI InChI=1S/C23H30N8O/c1-6-11-32-23-17(9-8-10-24-23)18-12-19(25-13-20-26-14-30(5)29-20)22-21(27-18)16(4)28-31(22)15(3)7-2/h8-10,12,14-15H,6-7,11,13H2,1-5H3,(H,25,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.120	n/a	n/a	n/a	n/a	7.6	25
H. Lundbeck A/S US Patent					Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...				US Patent US10034861 (2018) BindingDB Entry DOI: 10.7270/Q2X350HN
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (Homo sapiens (Human))	BDBM279103 (3-methyl-1-[1-methylpropyl]-N-[(1-methyl-1,2,4-tri...) Show SMILES CCCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(nc(C)c2n1)C(C)CC Show InChI InChI=1S/C23H30N8O/c1-6-11-32-23-17(9-8-10-24-23)18-12-19(25-13-20-26-14-30(5)29-20)22-21(27-18)16(4)28-31(22)15(3)7-2/h8-10,12,14-15H,6-7,11,13H2,1-5H3,(H,25,27)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	7.6	25
H. Lundbeck A/S US Patent					Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...				US Patent US10034861 (2018) BindingDB Entry DOI: 10.7270/Q2X350HN
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic phosphodiesterase 1A (Homo sapiens (Human))	BDBM279103 (3-methyl-1-[1-methylpropyl]-N-[(1-methyl-1,2,4-tri...) Show SMILES CCCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(nc(C)c2n1)C(C)CC Show InChI InChI=1S/C23H30N8O/c1-6-11-32-23-17(9-8-10-24-23)18-12-19(25-13-20-26-14-30(5)29-20)22-21(27-18)16(4)28-31(22)15(3)7-2/h8-10,12,14-15H,6-7,11,13H2,1-5H3,(H,25,27)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.960	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...				US Patent US10512632 (2019) BindingDB Entry DOI: 10.7270/Q25T3NVN
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM279103 (3-methyl-1-[1-methylpropyl]-N-[(1-methyl-1,2,4-tri...) Show SMILES CCCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(nc(C)c2n1)C(C)CC Show InChI InChI=1S/C23H30N8O/c1-6-11-32-23-17(9-8-10-24-23)18-12-19(25-13-20-26-14-30(5)29-20)22-21(27-18)16(4)28-31(22)15(3)7-2/h8-10,12,14-15H,6-7,11,13H2,1-5H3,(H,25,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.120	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...				US Patent US10512632 (2019) BindingDB Entry DOI: 10.7270/Q25T3NVN
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (Homo sapiens (Human))	BDBM279103 (3-methyl-1-[1-methylpropyl]-N-[(1-methyl-1,2,4-tri...) Show SMILES CCCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(nc(C)c2n1)C(C)CC Show InChI InChI=1S/C23H30N8O/c1-6-11-32-23-17(9-8-10-24-23)18-12-19(25-13-20-26-14-30(5)29-20)22-21(27-18)16(4)28-31(22)15(3)7-2/h8-10,12,14-15H,6-7,11,13H2,1-5H3,(H,25,27)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...				US Patent US10806718 (2020)
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic phosphodiesterase 1A (Homo sapiens (Human))	BDBM279103 (3-methyl-1-[1-methylpropyl]-N-[(1-methyl-1,2,4-tri...) Show SMILES CCCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(nc(C)c2n1)C(C)CC Show InChI InChI=1S/C23H30N8O/c1-6-11-32-23-17(9-8-10-24-23)18-12-19(25-13-20-26-14-30(5)29-20)22-21(27-18)16(4)28-31(22)15(3)7-2/h8-10,12,14-15H,6-7,11,13H2,1-5H3,(H,25,27)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.960	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...				US Patent US10766893 (2020)
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM279103 (3-methyl-1-[1-methylpropyl]-N-[(1-methyl-1,2,4-tri...) Show SMILES CCCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(nc(C)c2n1)C(C)CC Show InChI InChI=1S/C23H30N8O/c1-6-11-32-23-17(9-8-10-24-23)18-12-19(25-13-20-26-14-30(5)29-20)22-21(27-18)16(4)28-31(22)15(3)7-2/h8-10,12,14-15H,6-7,11,13H2,1-5H3,(H,25,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.120	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...				US Patent US10766893 (2020)
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (Homo sapiens (Human))	BDBM279103 (3-methyl-1-[1-methylpropyl]-N-[(1-methyl-1,2,4-tri...) Show SMILES CCCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(nc(C)c2n1)C(C)CC Show InChI InChI=1S/C23H30N8O/c1-6-11-32-23-17(9-8-10-24-23)18-12-19(25-13-20-26-14-30(5)29-20)22-21(27-18)16(4)28-31(22)15(3)7-2/h8-10,12,14-15H,6-7,11,13H2,1-5H3,(H,25,27)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...				US Patent US10766893 (2020)
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic phosphodiesterase 1A (Homo sapiens (Human))	BDBM279103 (3-methyl-1-[1-methylpropyl]-N-[(1-methyl-1,2,4-tri...) Show SMILES CCCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(nc(C)c2n1)C(C)CC Show InChI InChI=1S/C23H30N8O/c1-6-11-32-23-17(9-8-10-24-23)18-12-19(25-13-20-26-14-30(5)29-20)22-21(27-18)16(4)28-31(22)15(3)7-2/h8-10,12,14-15H,6-7,11,13H2,1-5H3,(H,25,27)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.960	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...				US Patent US10806718 (2020)
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM279103 (3-methyl-1-[1-methylpropyl]-N-[(1-methyl-1,2,4-tri...) Show SMILES CCCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(nc(C)c2n1)C(C)CC Show InChI InChI=1S/C23H30N8O/c1-6-11-32-23-17(9-8-10-24-23)18-12-19(25-13-20-26-14-30(5)29-20)22-21(27-18)16(4)28-31(22)15(3)7-2/h8-10,12,14-15H,6-7,11,13H2,1-5H3,(H,25,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.120	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...				US Patent US10806718 (2020)
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (Homo sapiens (Human))	BDBM279103 (3-methyl-1-[1-methylpropyl]-N-[(1-methyl-1,2,4-tri...) Show SMILES CCCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(nc(C)c2n1)C(C)CC Show InChI InChI=1S/C23H30N8O/c1-6-11-32-23-17(9-8-10-24-23)18-12-19(25-13-20-26-14-30(5)29-20)22-21(27-18)16(4)28-31(22)15(3)7-2/h8-10,12,14-15H,6-7,11,13H2,1-5H3,(H,25,27)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...				US Patent US10512632 (2019) BindingDB Entry DOI: 10.7270/Q25T3NVN
					More data for this Ligand-Target Pair