null

SMILES: CCOc1ncccc1-c1cc(NCc2cc(OC)ncn2)c2n(nc(C)c2n1)C(C)C

InChI Key: InChIKey=RTCQCKBUFIYEDZ-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 279148   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (Homo sapiens (Human))	BDBM279148 (5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(6-methoxypy...) Show SMILES CCOc1ncccc1-c1cc(NCc2cc(OC)ncn2)c2n(nc(C)c2n1)C(C)C Show InChI InChI=1S/C23H27N7O2/c1-6-32-23-17(8-7-9-24-23)18-11-19(25-12-16-10-20(31-5)27-13-26-16)22-21(28-18)15(4)29-30(22)14(2)3/h7-11,13-14H,6,12H2,1-5H3,(H,25,28)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.80	n/a	n/a	n/a	n/a	7.6	25
H. Lundbeck A/S US Patent					Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...				US Patent US10034861 (2018) BindingDB Entry DOI: 10.7270/Q2X350HN
					More data for this Ligand-Target Pair
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (Homo sapiens (Human))	BDBM279148 (5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(6-methoxypy...) Show SMILES CCOc1ncccc1-c1cc(NCc2cc(OC)ncn2)c2n(nc(C)c2n1)C(C)C Show InChI InChI=1S/C23H27N7O2/c1-6-32-23-17(8-7-9-24-23)18-11-19(25-12-16-10-20(31-5)27-13-26-16)22-21(28-18)15(4)29-30(22)14(2)3/h7-11,13-14H,6,12H2,1-5H3,(H,25,28)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78K2T
					More data for this Ligand-Target Pair
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (Homo sapiens (Human))	BDBM279148 (5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(6-methoxypy...) Show SMILES CCOc1ncccc1-c1cc(NCc2cc(OC)ncn2)c2n(nc(C)c2n1)C(C)C Show InChI InChI=1S/C23H27N7O2/c1-6-32-23-17(8-7-9-24-23)18-11-19(25-12-16-10-20(31-5)27-13-26-16)22-21(28-18)15(4)29-30(22)14(2)3/h7-11,13-14H,6,12H2,1-5H3,(H,25,28)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	7.6	25
H. Lundbeck A/S US Patent					Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...				US Patent US10034861 (2018) BindingDB Entry DOI: 10.7270/Q2X350HN
					More data for this Ligand-Target Pair
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (Homo sapiens (Human))	BDBM279148 (5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(6-methoxypy...) Show SMILES CCOc1ncccc1-c1cc(NCc2cc(OC)ncn2)c2n(nc(C)c2n1)C(C)C Show InChI InChI=1S/C23H27N7O2/c1-6-32-23-17(8-7-9-24-23)18-11-19(25-12-16-10-20(31-5)27-13-26-16)22-21(28-18)15(4)29-30(22)14(2)3/h7-11,13-14H,6,12H2,1-5H3,(H,25,28)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...				US Patent US10512632 (2019) BindingDB Entry DOI: 10.7270/Q25T3NVN
					More data for this Ligand-Target Pair
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM279148 (5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(6-methoxypy...) Show SMILES CCOc1ncccc1-c1cc(NCc2cc(OC)ncn2)c2n(nc(C)c2n1)C(C)C Show InChI InChI=1S/C23H27N7O2/c1-6-32-23-17(8-7-9-24-23)18-11-19(25-12-16-10-20(31-5)27-13-26-16)22-21(28-18)15(4)29-30(22)14(2)3/h7-11,13-14H,6,12H2,1-5H3,(H,25,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.510	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...				US Patent US10512632 (2019) BindingDB Entry DOI: 10.7270/Q25T3NVN
					More data for this Ligand-Target Pair
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (Homo sapiens (Human))	BDBM279148 (5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(6-methoxypy...) Show SMILES CCOc1ncccc1-c1cc(NCc2cc(OC)ncn2)c2n(nc(C)c2n1)C(C)C Show InChI InChI=1S/C23H27N7O2/c1-6-32-23-17(8-7-9-24-23)18-11-19(25-12-16-10-20(31-5)27-13-26-16)22-21(28-18)15(4)29-30(22)14(2)3/h7-11,13-14H,6,12H2,1-5H3,(H,25,28)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...				US Patent US10512632 (2019) BindingDB Entry DOI: 10.7270/Q25T3NVN
					More data for this Ligand-Target Pair
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (Homo sapiens (Human))	BDBM279148 (5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(6-methoxypy...) Show SMILES CCOc1ncccc1-c1cc(NCc2cc(OC)ncn2)c2n(nc(C)c2n1)C(C)C Show InChI InChI=1S/C23H27N7O2/c1-6-32-23-17(8-7-9-24-23)18-11-19(25-12-16-10-20(31-5)27-13-26-16)22-21(28-18)15(4)29-30(22)14(2)3/h7-11,13-14H,6,12H2,1-5H3,(H,25,28)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...				US Patent US10766893 (2020) BindingDB Entry DOI: 10.7270/Q2ZP495P
					More data for this Ligand-Target Pair
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM279148 (5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(6-methoxypy...) Show SMILES CCOc1ncccc1-c1cc(NCc2cc(OC)ncn2)c2n(nc(C)c2n1)C(C)C Show InChI InChI=1S/C23H27N7O2/c1-6-32-23-17(8-7-9-24-23)18-11-19(25-12-16-10-20(31-5)27-13-26-16)22-21(28-18)15(4)29-30(22)14(2)3/h7-11,13-14H,6,12H2,1-5H3,(H,25,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.510	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...				US Patent US10766893 (2020) BindingDB Entry DOI: 10.7270/Q2ZP495P
					More data for this Ligand-Target Pair
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (Homo sapiens (Human))	BDBM279148 (5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(6-methoxypy...) Show SMILES CCOc1ncccc1-c1cc(NCc2cc(OC)ncn2)c2n(nc(C)c2n1)C(C)C Show InChI InChI=1S/C23H27N7O2/c1-6-32-23-17(8-7-9-24-23)18-11-19(25-12-16-10-20(31-5)27-13-26-16)22-21(28-18)15(4)29-30(22)14(2)3/h7-11,13-14H,6,12H2,1-5H3,(H,25,28)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...				US Patent US10766893 (2020) BindingDB Entry DOI: 10.7270/Q2ZP495P
					More data for this Ligand-Target Pair
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (Homo sapiens (Human))	BDBM279148 (5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(6-methoxypy...) Show SMILES CCOc1ncccc1-c1cc(NCc2cc(OC)ncn2)c2n(nc(C)c2n1)C(C)C Show InChI InChI=1S/C23H27N7O2/c1-6-32-23-17(8-7-9-24-23)18-11-19(25-12-16-10-20(31-5)27-13-26-16)22-21(28-18)15(4)29-30(22)14(2)3/h7-11,13-14H,6,12H2,1-5H3,(H,25,28)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...				US Patent US10806718 (2020) BindingDB Entry DOI: 10.7270/Q27P92FR
					More data for this Ligand-Target Pair
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM279148 (5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(6-methoxypy...) Show SMILES CCOc1ncccc1-c1cc(NCc2cc(OC)ncn2)c2n(nc(C)c2n1)C(C)C Show InChI InChI=1S/C23H27N7O2/c1-6-32-23-17(8-7-9-24-23)18-11-19(25-12-16-10-20(31-5)27-13-26-16)22-21(28-18)15(4)29-30(22)14(2)3/h7-11,13-14H,6,12H2,1-5H3,(H,25,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.510	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...				US Patent US10806718 (2020) BindingDB Entry DOI: 10.7270/Q27P92FR
					More data for this Ligand-Target Pair
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (Homo sapiens (Human))	BDBM279148 (5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(6-methoxypy...) Show SMILES CCOc1ncccc1-c1cc(NCc2cc(OC)ncn2)c2n(nc(C)c2n1)C(C)C Show InChI InChI=1S/C23H27N7O2/c1-6-32-23-17(8-7-9-24-23)18-11-19(25-12-16-10-20(31-5)27-13-26-16)22-21(28-18)15(4)29-30(22)14(2)3/h7-11,13-14H,6,12H2,1-5H3,(H,25,28)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...				US Patent US10806718 (2020) BindingDB Entry DOI: 10.7270/Q27P92FR
					More data for this Ligand-Target Pair
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (Homo sapiens (Human))	BDBM279148 (5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(6-methoxypy...) Show SMILES CCOc1ncccc1-c1cc(NCc2cc(OC)ncn2)c2n(nc(C)c2n1)C(C)C Show InChI InChI=1S/C23H27N7O2/c1-6-32-23-17(8-7-9-24-23)18-11-19(25-12-16-10-20(31-5)27-13-26-16)22-21(28-18)15(4)29-30(22)14(2)3/h7-11,13-14H,6,12H2,1-5H3,(H,25,28)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...				US Patent US11026923 (2021) BindingDB Entry DOI: 10.7270/Q20R9SJ9
					More data for this Ligand-Target Pair
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM279148 (5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(6-methoxypy...) Show SMILES CCOc1ncccc1-c1cc(NCc2cc(OC)ncn2)c2n(nc(C)c2n1)C(C)C Show InChI InChI=1S/C23H27N7O2/c1-6-32-23-17(8-7-9-24-23)18-11-19(25-12-16-10-20(31-5)27-13-26-16)22-21(28-18)15(4)29-30(22)14(2)3/h7-11,13-14H,6,12H2,1-5H3,(H,25,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.510	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...				US Patent US11026923 (2021) BindingDB Entry DOI: 10.7270/Q20R9SJ9
					More data for this Ligand-Target Pair
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (Homo sapiens (Human))	BDBM279148 (5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(6-methoxypy...) Show SMILES CCOc1ncccc1-c1cc(NCc2cc(OC)ncn2)c2n(nc(C)c2n1)C(C)C Show InChI InChI=1S/C23H27N7O2/c1-6-32-23-17(8-7-9-24-23)18-11-19(25-12-16-10-20(31-5)27-13-26-16)22-21(28-18)15(4)29-30(22)14(2)3/h7-11,13-14H,6,12H2,1-5H3,(H,25,28)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...				US Patent US11026923 (2021) BindingDB Entry DOI: 10.7270/Q20R9SJ9
					More data for this Ligand-Target Pair
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (Homo sapiens (Human))	BDBM279148 (5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(6-methoxypy...) Show SMILES CCOc1ncccc1-c1cc(NCc2cc(OC)ncn2)c2n(nc(C)c2n1)C(C)C Show InChI InChI=1S/C23H27N7O2/c1-6-32-23-17(8-7-9-24-23)18-11-19(25-12-16-10-20(31-5)27-13-26-16)22-21(28-18)15(4)29-30(22)14(2)3/h7-11,13-14H,6,12H2,1-5H3,(H,25,28)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78K2T
					More data for this Ligand-Target Pair
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM279148 (5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(6-methoxypy...) Show SMILES CCOc1ncccc1-c1cc(NCc2cc(OC)ncn2)c2n(nc(C)c2n1)C(C)C Show InChI InChI=1S/C23H27N7O2/c1-6-32-23-17(8-7-9-24-23)18-11-19(25-12-16-10-20(31-5)27-13-26-16)22-21(28-18)15(4)29-30(22)14(2)3/h7-11,13-14H,6,12H2,1-5H3,(H,25,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.510	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78K2T
					More data for this Ligand-Target Pair
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM279148 (5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(6-methoxypy...) Show SMILES CCOc1ncccc1-c1cc(NCc2cc(OC)ncn2)c2n(nc(C)c2n1)C(C)C Show InChI InChI=1S/C23H27N7O2/c1-6-32-23-17(8-7-9-24-23)18-11-19(25-12-16-10-20(31-5)27-13-26-16)22-21(28-18)15(4)29-30(22)14(2)3/h7-11,13-14H,6,12H2,1-5H3,(H,25,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.510	n/a	n/a	n/a	n/a	7.6	25
H. Lundbeck A/S US Patent					Assay Description PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...				US Patent US10034861 (2018) BindingDB Entry DOI: 10.7270/Q2X350HN
					More data for this Ligand-Target Pair