BDBM27964 3-(2-(2-methoxybenzyl)-1H-benzo[d]imidazol-5-yl)-1-((1r,4r)-4-morpholinocyclohexyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine::3-(2-(2-methoxybenzyl)-1H-benzo[d]imidazol-6-yl)-1-((trans)-4-morpholinocyclohexyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine::3-{2-[(2-methoxyphenyl)methyl]-1H-1,3-benzodiazol-6-yl}-1-[4-(morpholin-4-yl)cyclohexyl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine::CHEMBL437584::substituted benzimidazole, 9
SMILES: COc1ccccc1Cc1nc2ccc(cc2[nH]1)-c1nn([C@H]2CC[C@@H](CC2)N2CCOCC2)c2ncnc(N)c12
InChI Key: InChIKey=YETDQFJRLHRQJD-HZCBDIJESA-N
Data: 5 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Insulin-like growth factor I receptor (Homo sapiens (Human)) | BDBM27964 (3-(2-(2-methoxybenzyl)-1H-benzo[d]imidazol-5-yl)-1...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 81 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Abbott Laboratories | Assay Description Assays were performed in 96-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of ... | Bioorg Med Chem Lett 19: 1718-21 (2009) Article DOI: 10.1016/j.bmcl.2009.01.086 BindingDB Entry DOI: 10.7270/Q2CJ8BTG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
EGF-R Tyrosine Kinase Mutant (L858R) (Homo sapiens (Human)) | BDBM27964 (3-(2-(2-methoxybenzyl)-1H-benzo[d]imidazol-5-yl)-1...) | PDB MMDB B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 58 | n/a | n/a | n/a | n/a | 7.5 | 23 |
Abbott Laboratories | Assay Description Assays were performed in 96-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of ... | Bioorg Med Chem Lett 19: 1718-21 (2009) Article DOI: 10.1016/j.bmcl.2009.01.086 BindingDB Entry DOI: 10.7270/Q2CJ8BTG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Insulin-like growth factor I receptor (Homo sapiens (Human)) | BDBM27964 (3-(2-(2-methoxybenzyl)-1H-benzo[d]imidazol-5-yl)-1...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 142 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description Inhibition IGF1R phosphorylation in human MiaPaCa2 cells | Bioorg Med Chem Lett 17: 5406-9 (2007) Article DOI: 10.1016/j.bmcl.2007.07.037 BindingDB Entry DOI: 10.7270/Q20P0ZRZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Insulin-like growth factor I receptor (Homo sapiens (Human)) | BDBM27964 (3-(2-(2-methoxybenzyl)-1H-benzo[d]imidazol-5-yl)-1...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 81 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description Inhibition of human IGF1R expressed in Sf21 cells by time-resolved fluorescence assay | Bioorg Med Chem Lett 17: 5406-9 (2007) Article DOI: 10.1016/j.bmcl.2007.07.037 BindingDB Entry DOI: 10.7270/Q20P0ZRZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor tyrosine-protein kinase erbB-2 (Homo sapiens (Human)) | BDBM27964 (3-(2-(2-methoxybenzyl)-1H-benzo[d]imidazol-5-yl)-1...) | PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 53 | n/a | n/a | n/a | n/a | 7.5 | 23 |
Abbott Laboratories | Assay Description Assays were performed in 96-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of ... | Bioorg Med Chem Lett 19: 1718-21 (2009) Article DOI: 10.1016/j.bmcl.2009.01.086 BindingDB Entry DOI: 10.7270/Q2CJ8BTG | |||||||||||
More data for this Ligand-Target Pair |