BDBM27997 N-(2-phenoxyethyl)-2-{[2-(pyridin-3-yl)ethyl]amino}-4-(3,4,5-trimethoxyphenyl)pyrimidine-5-carboxamide::trisubstituted pyrimidine analogue, 6r

SMILES: COc1cc(cc(OC)c1OC)-c1nc(NCCc2cccnc2)ncc1C(=O)NCCOc1ccccc1

InChI Key: InChIKey=GAWPWWPXSMCQKZ-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 27997   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Calcium-sensing receptor (CaSR) (Homo sapiens (Human))	BDBM27997 (N-(2-phenoxyethyl)-2-{[2-(pyridin-3-yl)ethyl]amino...) Show SMILES COc1cc(cc(OC)c1OC)-c1nc(NCCc2cccnc2)ncc1C(=O)NCCOc1ccccc1 Show InChI InChI=1S/C29H31N5O5/c1-36-24-16-21(17-25(37-2)27(24)38-3)26-23(28(35)31-14-15-39-22-9-5-4-6-10-22)19-33-29(34-26)32-13-11-20-8-7-12-30-18-20/h4-10,12,16-19H,11,13-15H2,1-3H3,(H,31,35)(H,32,33,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	7.5	37
Bristol-Myers Squibb Company					Assay Description Antagonist activity of test compounds was measured in HEK293 cells stably expressing the human recombinant CaR (HEK-CaR) by determining the ability o...				J Med Chem 52: 1204-8 (2009) Article DOI: 10.1021/jm801178c BindingDB Entry DOI: 10.7270/Q2416VCR
					More data for this Ligand-Target Pair