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BDBM280034 US10028961, Compound 187::US10172864, Compound 187

SMILES: CC(F)(F)c1cccc(n1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1

InChI Key:

Data: 8 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 280034   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
IDH1 R132H


(Homo sapiens (Human))
BDBM280034
PNG
(US10028961, Compound 187 | US10172864, Compound 18...)
Show SMILES CC(F)(F)c1cccc(n1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<50n/an/an/an/a6.525



Agios Pharmaceuticals, Inc.

US Patent




US Patent US10028961 (2018)


BindingDB Entry DOI: 10.7270/Q2ZW1NXM
More data for this
Ligand-Target Pair
IDH1 R132C


(Homo sapiens (Human))
BDBM280034
PNG
(US10028961, Compound 187 | US10172864, Compound 18...)
Show SMILES CC(F)(F)c1cccc(n1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<50n/an/an/an/a6.525



Agios Pharmaceuticals, Inc.

US Patent




US Patent US10028961 (2018)


BindingDB Entry DOI: 10.7270/Q2ZW1NXM
More data for this
Ligand-Target Pair
IDH2(R140Q)


(Homo sapiens (Human))
BDBM280034
PNG
(US10028961, Compound 187 | US10172864, Compound 18...)
Show SMILES CC(F)(F)c1cccc(n1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<50n/an/an/an/a7.525



Agios Pharmaceuticals, Inc.

US Patent




US Patent US10028961 (2018)


BindingDB Entry DOI: 10.7270/Q2ZW1NXM
More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (Human))
BDBM280034
PNG
(US10028961, Compound 187 | US10172864, Compound 18...)
Show SMILES CC(F)(F)c1cccc(n1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/an/an/a



Agios Pharmaceuticals, Inc.

US Patent




US Patent US10172864 (2019)


BindingDB Entry DOI: 10.7270/Q2ZK5JQ3
More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (Human))
BDBM280034
PNG
(US10028961, Compound 187 | US10172864, Compound 18...)
Show SMILES CC(F)(F)c1cccc(n1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



Agios Pharmaceuticals, Inc.

US Patent




US Patent US10172864 (2019)


BindingDB Entry DOI: 10.7270/Q2ZK5JQ3
More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (Human))
BDBM280034
PNG
(US10028961, Compound 187 | US10172864, Compound 18...)
Show SMILES CC(F)(F)c1cccc(n1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



Agios Pharmaceuticals, Inc.

US Patent




US Patent US10172864 (2019)


BindingDB Entry DOI: 10.7270/Q2ZK5JQ3
More data for this
Ligand-Target Pair
IDH2(R140Q)


(Homo sapiens (Human))
BDBM280034
PNG
(US10028961, Compound 187 | US10172864, Compound 18...)
Show SMILES CC(F)(F)c1cccc(n1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



Agios Pharmaceuticals, Inc.

US Patent




US Patent US10172864 (2019)


BindingDB Entry DOI: 10.7270/Q2ZK5JQ3
More data for this
Ligand-Target Pair
IDH1 R132H


(Homo sapiens (Human))
BDBM280034
PNG
(US10028961, Compound 187 | US10172864, Compound 18...)
Show SMILES CC(F)(F)c1cccc(n1)-c1nc(NC2CC(F)(F)C2)nc(NC2CC(F)(F)C2)n1
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 550n/an/an/an/a7.525



Agios Pharmaceuticals, Inc.

US Patent




US Patent US10028961 (2018)


BindingDB Entry DOI: 10.7270/Q2ZW1NXM
More data for this
Ligand-Target Pair