BDBM28018 2-(2,6-dimethoxypyridin-3-yl)-6-{[(2S)-1-hydroxy-3-phenylpropan-2-yl]amino}-N-(2-phenoxyethyl)pyridine-3-carboxamide::trisubstituted pyridine analogue, 18d

SMILES: COc1ccc(c(OC)n1)-c1nc(N[C@H](CO)Cc2ccccc2)ccc1C(=O)NCCOc1ccccc1

InChI Key: InChIKey=CHNHTXIKBXJBRC-QFIPXVFZSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 28018   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Calcium-sensing receptor (CaSR) (Homo sapiens (Human))	BDBM28018 (2-(2,6-dimethoxypyridin-3-yl)-6-{[(2S)-1-hydroxy-3...) Show SMILES COc1ccc(c(OC)n1)-c1nc(N[C@H](CO)Cc2ccccc2)ccc1C(=O)NCCOc1ccccc1 |r| Show InChI InChI=1S/C30H32N4O5/c1-37-27-16-14-25(30(34-27)38-2)28-24(29(36)31-17-18-39-23-11-7-4-8-12-23)13-15-26(33-28)32-22(20-35)19-21-9-5-3-6-10-21/h3-16,22,35H,17-20H2,1-2H3,(H,31,36)(H,32,33)/t22-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description Antagonist activity of test compounds was measured in HEK293 cells stably expressing the human recombinant CaR (HEK-CaR) by determining the ability o...				J Med Chem 52: 1204-8 (2009) Article DOI: 10.1021/jm801178c BindingDB Entry DOI: 10.7270/Q2416VCR
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