BDBM28022 6-{[(3-chlorophenyl)methyl]amino}-2-(2,6-dimethoxypyridin-3-yl)-N-(2-phenoxyethyl)pyridine-3-carboxamide::trisubstituted pyridine analogue, 18h

SMILES: COc1ccc(c(OC)n1)-c1nc(NCc2cccc(Cl)c2)ccc1C(=O)NCCOc1ccccc1

InChI Key: InChIKey=VVUBACWATYILLD-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 28022   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Calcium-sensing receptor (CaSR) (Homo sapiens (Human))	BDBM28022 (6-{[(3-chlorophenyl)methyl]amino}-2-(2,6-dimethoxy...) Show SMILES COc1ccc(c(OC)n1)-c1nc(NCc2cccc(Cl)c2)ccc1C(=O)NCCOc1ccccc1 Show InChI InChI=1S/C28H27ClN4O4/c1-35-25-14-12-23(28(33-25)36-2)26-22(27(34)30-15-16-37-21-9-4-3-5-10-21)11-13-24(32-26)31-18-19-7-6-8-20(29)17-19/h3-14,17H,15-16,18H2,1-2H3,(H,30,34)(H,31,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	197	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description Antagonist activity of test compounds was measured in HEK293 cells stably expressing the human recombinant CaR (HEK-CaR) by determining the ability o...				J Med Chem 52: 1204-8 (2009) Article DOI: 10.1021/jm801178c BindingDB Entry DOI: 10.7270/Q2416VCR
					More data for this Ligand-Target Pair