BDBM28032 2-aminopyridine analogue, 11::N-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorophenyl}-1-(4-fluorophenyl)-2-oxo-4-(propan-2-yloxy)-1,2-dihydropyridine-3-carboxamide

SMILES: CC(C)Oc1ccn(-c2ccc(F)cc2)c(=O)c1C(=O)Nc1ccc(Oc2ccnc(N)c2Cl)c(F)c1

InChI Key: InChIKey=BBVQJPURZDEFJS-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 28032   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM28032 (2-aminopyridine analogue, 11 | N-{4-[(2-amino-3-ch...) Show SMILES CC(C)Oc1ccn(-c2ccc(F)cc2)c(=O)c1C(=O)Nc1ccc(Oc2ccnc(N)c2Cl)c(F)c1 Show InChI InChI=1S/C26H21ClF2N4O4/c1-14(2)36-20-10-12-33(17-6-3-15(28)4-7-17)26(35)22(20)25(34)32-16-5-8-19(18(29)13-16)37-21-9-11-31-24(30)23(21)27/h3-14H,1-2H3,(H2,30,31)(H,32,34)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of human c-MET				Eur J Med Chem 46: 3675-80 (2011) Article DOI: 10.1016/j.ejmech.2011.05.031 BindingDB Entry DOI: 10.7270/Q2891676
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM28032 (2-aminopyridine analogue, 11 | N-{4-[(2-amino-3-ch...) Show SMILES CC(C)Oc1ccn(-c2ccc(F)cc2)c(=O)c1C(=O)Nc1ccc(Oc2ccnc(N)c2Cl)c(F)c1 Show InChI InChI=1S/C26H21ClF2N4O4/c1-14(2)36-20-10-12-33(17-6-3-15(28)4-7-17)26(35)22(20)25(34)32-16-5-8-19(18(29)13-16)37-21-9-11-31-24(30)23(21)27/h3-14H,1-2H3,(H2,30,31)(H,32,34)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.20	n/a	n/a	n/a	n/a	7.5	30
Bristol-Myers Squibb Company					Assay Description Kinase activity was assayed using baculovirus expressed GST-Met, and poly(Glu/Tyr) as the substrate in the presence of test compound. Dose response c...				J Med Chem 52: 1251-4 (2009) Article DOI: 10.1021/jm801586s BindingDB Entry DOI: 10.7270/Q20863MZ
					More data for this Ligand-Target Pair