BDBM280350 4-[[2-(5-chloro-2-fluoro-phenyl)-5-(1-methoxy-1-methyl-ethyl)-4-pyridyl]amino]-N-(2-hydroxypropyl)pyridine-3-carboxamide::US10030004, Compound 17a::US10501436, Compound 17a

SMILES: COC(C)(C)c1cnc(cc1Nc1ccncc1C(=O)NCC(C)O)-c1cc(Cl)ccc1F

InChI Key: InChIKey=QGMSQMSDEUEWCM-UHFFFAOYSA-N

Data: 12 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 280350   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase receptor R3 (Homo sapiens (Human))	BDBM280350 (4-[[2-(5-chloro-2-fluoro-phenyl)-5-(1-methoxy-1-me...) Show SMILES COC(C)(C)c1cnc(cc1Nc1ccncc1C(=O)NCC(C)O)-c1cc(Cl)ccc1F Show InChI InChI=1S/C24H26ClFN4O3/c1-14(31)11-29-23(32)17-12-27-8-7-20(17)30-22-10-21(16-9-15(25)5-6-19(16)26)28-13-18(22)24(2,3)33-4/h5-10,12-14,31H,11H2,1-4H3,(H,29,32)(H,27,28,30)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.67E+3	n/a	n/a	n/a	n/a	n/a	n/a
Medivation Technologies LLC US Patent					Assay Description Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...				US Patent US10030004 (2018) BindingDB Entry DOI: 10.7270/Q2QC05HQ
					More data for this Ligand-Target Pair
Bone morphogenetic protein 10 (Homo sapiens (Human))	BDBM280350 (4-[[2-(5-chloro-2-fluoro-phenyl)-5-(1-methoxy-1-me...) Show SMILES COC(C)(C)c1cnc(cc1Nc1ccncc1C(=O)NCC(C)O)-c1cc(Cl)ccc1F Show InChI InChI=1S/C24H26ClFN4O3/c1-14(31)11-29-23(32)17-12-27-8-7-20(17)30-22-10-21(16-9-15(25)5-6-19(16)26)28-13-18(22)24(2,3)33-4/h5-10,12-14,31H,11H2,1-4H3,(H,29,32)(H,27,28,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Activin receptor-like kinase 3 (ALK-3) (Homo sapiens (Human))	BDBM280350 (4-[[2-(5-chloro-2-fluoro-phenyl)-5-(1-methoxy-1-me...) Show SMILES COC(C)(C)c1cnc(cc1Nc1ccncc1C(=O)NCC(C)O)-c1cc(Cl)ccc1F Show InChI InChI=1S/C24H26ClFN4O3/c1-14(31)11-29-23(32)17-12-27-8-7-20(17)30-22-10-21(16-9-15(25)5-6-19(16)26)28-13-18(22)24(2,3)33-4/h5-10,12-14,31H,11H2,1-4H3,(H,29,32)(H,27,28,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Medivation Technologies LLC US Patent					Assay Description Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...				US Patent US10030004 (2018) BindingDB Entry DOI: 10.7270/Q2QC05HQ
					More data for this Ligand-Target Pair
Activin receptor type-1B (Homo sapiens (Human))	BDBM280350 (4-[[2-(5-chloro-2-fluoro-phenyl)-5-(1-methoxy-1-me...) Show SMILES COC(C)(C)c1cnc(cc1Nc1ccncc1C(=O)NCC(C)O)-c1cc(Cl)ccc1F Show InChI InChI=1S/C24H26ClFN4O3/c1-14(31)11-29-23(32)17-12-27-8-7-20(17)30-22-10-21(16-9-15(25)5-6-19(16)26)28-13-18(22)24(2,3)33-4/h5-10,12-14,31H,11H2,1-4H3,(H,29,32)(H,27,28,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	40.1	n/a	n/a	n/a	n/a	n/a	n/a
Medivation Technologies LLC US Patent					Assay Description Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...				US Patent US10030004 (2018) BindingDB Entry DOI: 10.7270/Q2QC05HQ
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM280350 (4-[[2-(5-chloro-2-fluoro-phenyl)-5-(1-methoxy-1-me...) Show SMILES COC(C)(C)c1cnc(cc1Nc1ccncc1C(=O)NCC(C)O)-c1cc(Cl)ccc1F Show InChI InChI=1S/C24H26ClFN4O3/c1-14(31)11-29-23(32)17-12-27-8-7-20(17)30-22-10-21(16-9-15(25)5-6-19(16)26)28-13-18(22)24(2,3)33-4/h5-10,12-14,31H,11H2,1-4H3,(H,29,32)(H,27,28,30)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	50.8	n/a	n/a	n/a	n/a	n/a	n/a
Medivation Technologies LLC US Patent					Assay Description Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...				US Patent US10030004 (2018) BindingDB Entry DOI: 10.7270/Q2QC05HQ
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1B (Mus musculus (Mouse))	BDBM280350 (4-[[2-(5-chloro-2-fluoro-phenyl)-5-(1-methoxy-1-me...) Show SMILES COC(C)(C)c1cnc(cc1Nc1ccncc1C(=O)NCC(C)O)-c1cc(Cl)ccc1F Show InChI InChI=1S/C24H26ClFN4O3/c1-14(31)11-29-23(32)17-12-27-8-7-20(17)30-22-10-21(16-9-15(25)5-6-19(16)26)28-13-18(22)24(2,3)33-4/h5-10,12-14,31H,11H2,1-4H3,(H,29,32)(H,27,28,30)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Medivation Technologies LLC US Patent					Assay Description Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...				US Patent US10030004 (2018) BindingDB Entry DOI: 10.7270/Q2QC05HQ
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase receptor R3 (Homo sapiens (Human))	BDBM280350 (4-[[2-(5-chloro-2-fluoro-phenyl)-5-(1-methoxy-1-me...) Show SMILES COC(C)(C)c1cnc(cc1Nc1ccncc1C(=O)NCC(C)O)-c1cc(Cl)ccc1F Show InChI InChI=1S/C24H26ClFN4O3/c1-14(31)11-29-23(32)17-12-27-8-7-20(17)30-22-10-21(16-9-15(25)5-6-19(16)26)28-13-18(22)24(2,3)33-4/h5-10,12-14,31H,11H2,1-4H3,(H,29,32)(H,27,28,30)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.67E+3	n/a	n/a	n/a	n/a	n/a	n/a
Medivation Technologies LLC US Patent					Assay Description Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...				US Patent US10501436 (2019) BindingDB Entry DOI: 10.7270/Q20867PH
					More data for this Ligand-Target Pair
Activin receptor type-1 (Homo sapiens (Human))	BDBM280350 (4-[[2-(5-chloro-2-fluoro-phenyl)-5-(1-methoxy-1-me...) Show SMILES COC(C)(C)c1cnc(cc1Nc1ccncc1C(=O)NCC(C)O)-c1cc(Cl)ccc1F Show InChI InChI=1S/C24H26ClFN4O3/c1-14(31)11-29-23(32)17-12-27-8-7-20(17)30-22-10-21(16-9-15(25)5-6-19(16)26)28-13-18(22)24(2,3)33-4/h5-10,12-14,31H,11H2,1-4H3,(H,29,32)(H,27,28,30)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Medivation Technologies LLC US Patent					Assay Description Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...				US Patent US10501436 (2019) BindingDB Entry DOI: 10.7270/Q20867PH
					More data for this Ligand-Target Pair
Activin receptor-like kinase 3 (ALK-3) (Homo sapiens (Human))	BDBM280350 (4-[[2-(5-chloro-2-fluoro-phenyl)-5-(1-methoxy-1-me...) Show SMILES COC(C)(C)c1cnc(cc1Nc1ccncc1C(=O)NCC(C)O)-c1cc(Cl)ccc1F Show InChI InChI=1S/C24H26ClFN4O3/c1-14(31)11-29-23(32)17-12-27-8-7-20(17)30-22-10-21(16-9-15(25)5-6-19(16)26)28-13-18(22)24(2,3)33-4/h5-10,12-14,31H,11H2,1-4H3,(H,29,32)(H,27,28,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Medivation Technologies LLC US Patent					Assay Description Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...				US Patent US10501436 (2019) BindingDB Entry DOI: 10.7270/Q20867PH
					More data for this Ligand-Target Pair
Activin receptor type-1B (Homo sapiens (Human))	BDBM280350 (4-[[2-(5-chloro-2-fluoro-phenyl)-5-(1-methoxy-1-me...) Show SMILES COC(C)(C)c1cnc(cc1Nc1ccncc1C(=O)NCC(C)O)-c1cc(Cl)ccc1F Show InChI InChI=1S/C24H26ClFN4O3/c1-14(31)11-29-23(32)17-12-27-8-7-20(17)30-22-10-21(16-9-15(25)5-6-19(16)26)28-13-18(22)24(2,3)33-4/h5-10,12-14,31H,11H2,1-4H3,(H,29,32)(H,27,28,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	40.1	n/a	n/a	n/a	n/a	n/a	n/a
Medivation Technologies LLC US Patent					Assay Description Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...				US Patent US10501436 (2019) BindingDB Entry DOI: 10.7270/Q20867PH
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM280350 (4-[[2-(5-chloro-2-fluoro-phenyl)-5-(1-methoxy-1-me...) Show SMILES COC(C)(C)c1cnc(cc1Nc1ccncc1C(=O)NCC(C)O)-c1cc(Cl)ccc1F Show InChI InChI=1S/C24H26ClFN4O3/c1-14(31)11-29-23(32)17-12-27-8-7-20(17)30-22-10-21(16-9-15(25)5-6-19(16)26)28-13-18(22)24(2,3)33-4/h5-10,12-14,31H,11H2,1-4H3,(H,29,32)(H,27,28,30)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	50.8	n/a	n/a	n/a	n/a	n/a	n/a
Medivation Technologies LLC US Patent					Assay Description Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...				US Patent US10501436 (2019) BindingDB Entry DOI: 10.7270/Q20867PH
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1B (Homo sapiens (Human))	BDBM280350 (4-[[2-(5-chloro-2-fluoro-phenyl)-5-(1-methoxy-1-me...) Show SMILES COC(C)(C)c1cnc(cc1Nc1ccncc1C(=O)NCC(C)O)-c1cc(Cl)ccc1F Show InChI InChI=1S/C24H26ClFN4O3/c1-14(31)11-29-23(32)17-12-27-8-7-20(17)30-22-10-21(16-9-15(25)5-6-19(16)26)28-13-18(22)24(2,3)33-4/h5-10,12-14,31H,11H2,1-4H3,(H,29,32)(H,27,28,30)	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Medivation Technologies LLC US Patent					Assay Description Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...				US Patent US10501436 (2019) BindingDB Entry DOI: 10.7270/Q20867PH
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase receptor R3 (Homo sapiens (Human))	BDBM280350 (4-[[2-(5-chloro-2-fluoro-phenyl)-5-(1-methoxy-1-me...) Show SMILES COC(C)(C)c1cnc(cc1Nc1ccncc1C(=O)NCC(C)O)-c1cc(Cl)ccc1F Show InChI InChI=1S/C24H26ClFN4O3/c1-14(31)11-29-23(32)17-12-27-8-7-20(17)30-22-10-21(16-9-15(25)5-6-19(16)26)28-13-18(22)24(2,3)33-4/h5-10,12-14,31H,11H2,1-4H3,(H,29,32)(H,27,28,30)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	4.67E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Activin receptor type-1 (Homo sapiens (Human))	BDBM280350 (4-[[2-(5-chloro-2-fluoro-phenyl)-5-(1-methoxy-1-me...) Show SMILES COC(C)(C)c1cnc(cc1Nc1ccncc1C(=O)NCC(C)O)-c1cc(Cl)ccc1F Show InChI InChI=1S/C24H26ClFN4O3/c1-14(31)11-29-23(32)17-12-27-8-7-20(17)30-22-10-21(16-9-15(25)5-6-19(16)26)28-13-18(22)24(2,3)33-4/h5-10,12-14,31H,11H2,1-4H3,(H,29,32)(H,27,28,30)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Activin receptor-like kinase 3 (ALK-3) (Homo sapiens (Human))	BDBM280350 (4-[[2-(5-chloro-2-fluoro-phenyl)-5-(1-methoxy-1-me...) Show SMILES COC(C)(C)c1cnc(cc1Nc1ccncc1C(=O)NCC(C)O)-c1cc(Cl)ccc1F Show InChI InChI=1S/C24H26ClFN4O3/c1-14(31)11-29-23(32)17-12-27-8-7-20(17)30-22-10-21(16-9-15(25)5-6-19(16)26)28-13-18(22)24(2,3)33-4/h5-10,12-14,31H,11H2,1-4H3,(H,29,32)(H,27,28,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Activin receptor type-1B (Homo sapiens (Human))	BDBM280350 (4-[[2-(5-chloro-2-fluoro-phenyl)-5-(1-methoxy-1-me...) Show SMILES COC(C)(C)c1cnc(cc1Nc1ccncc1C(=O)NCC(C)O)-c1cc(Cl)ccc1F Show InChI InChI=1S/C24H26ClFN4O3/c1-14(31)11-29-23(32)17-12-27-8-7-20(17)30-22-10-21(16-9-15(25)5-6-19(16)26)28-13-18(22)24(2,3)33-4/h5-10,12-14,31H,11H2,1-4H3,(H,29,32)(H,27,28,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	40.1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM280350 (4-[[2-(5-chloro-2-fluoro-phenyl)-5-(1-methoxy-1-me...) Show SMILES COC(C)(C)c1cnc(cc1Nc1ccncc1C(=O)NCC(C)O)-c1cc(Cl)ccc1F Show InChI InChI=1S/C24H26ClFN4O3/c1-14(31)11-29-23(32)17-12-27-8-7-20(17)30-22-10-21(16-9-15(25)5-6-19(16)26)28-13-18(22)24(2,3)33-4/h5-10,12-14,31H,11H2,1-4H3,(H,29,32)(H,27,28,30)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	50.8	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Activin receptor type-1 (Homo sapiens (Human))	BDBM280350 (4-[[2-(5-chloro-2-fluoro-phenyl)-5-(1-methoxy-1-me...) Show SMILES COC(C)(C)c1cnc(cc1Nc1ccncc1C(=O)NCC(C)O)-c1cc(Cl)ccc1F Show InChI InChI=1S/C24H26ClFN4O3/c1-14(31)11-29-23(32)17-12-27-8-7-20(17)30-22-10-21(16-9-15(25)5-6-19(16)26)28-13-18(22)24(2,3)33-4/h5-10,12-14,31H,11H2,1-4H3,(H,29,32)(H,27,28,30)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Medivation Technologies LLC US Patent					Assay Description Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...				US Patent US10030004 (2018) BindingDB Entry DOI: 10.7270/Q2QC05HQ
					More data for this Ligand-Target Pair