null

SMILES: CC(O)CNC(=O)c1cnccc1Nc1cc(ncc1C(C)C)-c1ccccc1

InChI Key: InChIKey=XDHZSOHHUNDLNQ-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 280362   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase receptor R3 (Homo sapiens (Human))	BDBM280362 (N-[(2S)-2-hydroxypropyl]-4-{[2-phenyl-5-(propan-2-...) Show SMILES CC(O)CNC(=O)c1cnccc1Nc1cc(ncc1C(C)C)-c1ccccc1 Show InChI InChI=1S/C23H26N4O2/c1-15(2)18-14-25-21(17-7-5-4-6-8-17)11-22(18)27-20-9-10-24-13-19(20)23(29)26-12-16(3)28/h4-11,13-16,28H,12H2,1-3H3,(H,26,29)(H,24,25,27)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Medivation Technologies LLC US Patent					Assay Description Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...				US Patent US10030004 (2018) BindingDB Entry DOI: 10.7270/Q2QC05HQ
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1B (Homo sapiens (Human))	BDBM280362 (N-[(2S)-2-hydroxypropyl]-4-{[2-phenyl-5-(propan-2-...) Show SMILES CC(O)CNC(=O)c1cnccc1Nc1cc(ncc1C(C)C)-c1ccccc1 Show InChI InChI=1S/C23H26N4O2/c1-15(2)18-14-25-21(17-7-5-4-6-8-17)11-22(18)27-20-9-10-24-13-19(20)23(29)26-12-16(3)28/h4-11,13-16,28H,12H2,1-3H3,(H,26,29)(H,24,25,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q24M98N9
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1A (Homo sapiens (Human))	BDBM280362 (N-[(2S)-2-hydroxypropyl]-4-{[2-phenyl-5-(propan-2-...) Show SMILES CC(O)CNC(=O)c1cnccc1Nc1cc(ncc1C(C)C)-c1ccccc1 Show InChI InChI=1S/C23H26N4O2/c1-15(2)18-14-25-21(17-7-5-4-6-8-17)11-22(18)27-20-9-10-24-13-19(20)23(29)26-12-16(3)28/h4-11,13-16,28H,12H2,1-3H3,(H,26,29)(H,24,25,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Medivation Technologies LLC US Patent					Assay Description Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...				US Patent US10030004 (2018) BindingDB Entry DOI: 10.7270/Q2QC05HQ
					More data for this Ligand-Target Pair
Activin receptor type-1B (Homo sapiens (Human))	BDBM280362 (N-[(2S)-2-hydroxypropyl]-4-{[2-phenyl-5-(propan-2-...) Show SMILES CC(O)CNC(=O)c1cnccc1Nc1cc(ncc1C(C)C)-c1ccccc1 Show InChI InChI=1S/C23H26N4O2/c1-15(2)18-14-25-21(17-7-5-4-6-8-17)11-22(18)27-20-9-10-24-13-19(20)23(29)26-12-16(3)28/h4-11,13-16,28H,12H2,1-3H3,(H,26,29)(H,24,25,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Medivation Technologies LLC US Patent					Assay Description Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...				US Patent US10030004 (2018) BindingDB Entry DOI: 10.7270/Q2QC05HQ
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM280362 (N-[(2S)-2-hydroxypropyl]-4-{[2-phenyl-5-(propan-2-...) Show SMILES CC(O)CNC(=O)c1cnccc1Nc1cc(ncc1C(C)C)-c1ccccc1 Show InChI InChI=1S/C23H26N4O2/c1-15(2)18-14-25-21(17-7-5-4-6-8-17)11-22(18)27-20-9-10-24-13-19(20)23(29)26-12-16(3)28/h4-11,13-16,28H,12H2,1-3H3,(H,26,29)(H,24,25,27)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	551	n/a	n/a	n/a	n/a	n/a	n/a
Medivation Technologies LLC US Patent					Assay Description Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...				US Patent US10030004 (2018) BindingDB Entry DOI: 10.7270/Q2QC05HQ
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1B (Mus musculus (Mouse))	BDBM280362 (N-[(2S)-2-hydroxypropyl]-4-{[2-phenyl-5-(propan-2-...) Show SMILES CC(O)CNC(=O)c1cnccc1Nc1cc(ncc1C(C)C)-c1ccccc1 Show InChI InChI=1S/C23H26N4O2/c1-15(2)18-14-25-21(17-7-5-4-6-8-17)11-22(18)27-20-9-10-24-13-19(20)23(29)26-12-16(3)28/h4-11,13-16,28H,12H2,1-3H3,(H,26,29)(H,24,25,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Medivation Technologies LLC US Patent					Assay Description Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...				US Patent US10030004 (2018) BindingDB Entry DOI: 10.7270/Q2QC05HQ
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase receptor R3 (Homo sapiens (Human))	BDBM280362 (N-[(2S)-2-hydroxypropyl]-4-{[2-phenyl-5-(propan-2-...) Show SMILES CC(O)CNC(=O)c1cnccc1Nc1cc(ncc1C(C)C)-c1ccccc1 Show InChI InChI=1S/C23H26N4O2/c1-15(2)18-14-25-21(17-7-5-4-6-8-17)11-22(18)27-20-9-10-24-13-19(20)23(29)26-12-16(3)28/h4-11,13-16,28H,12H2,1-3H3,(H,26,29)(H,24,25,27)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...				Citation and Details BindingDB Entry DOI: 10.7270/Q2W380HG
					More data for this Ligand-Target Pair
Activin receptor type-1 (Homo sapiens (Human))	BDBM280362 (N-[(2S)-2-hydroxypropyl]-4-{[2-phenyl-5-(propan-2-...) Show SMILES CC(O)CNC(=O)c1cnccc1Nc1cc(ncc1C(C)C)-c1ccccc1 Show InChI InChI=1S/C23H26N4O2/c1-15(2)18-14-25-21(17-7-5-4-6-8-17)11-22(18)27-20-9-10-24-13-19(20)23(29)26-12-16(3)28/h4-11,13-16,28H,12H2,1-3H3,(H,26,29)(H,24,25,27)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q2W380HG
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1A (Homo sapiens (Human))	BDBM280362 (N-[(2S)-2-hydroxypropyl]-4-{[2-phenyl-5-(propan-2-...) Show SMILES CC(O)CNC(=O)c1cnccc1Nc1cc(ncc1C(C)C)-c1ccccc1 Show InChI InChI=1S/C23H26N4O2/c1-15(2)18-14-25-21(17-7-5-4-6-8-17)11-22(18)27-20-9-10-24-13-19(20)23(29)26-12-16(3)28/h4-11,13-16,28H,12H2,1-3H3,(H,26,29)(H,24,25,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q2W380HG
					More data for this Ligand-Target Pair
Activin receptor type-1B (Homo sapiens (Human))	BDBM280362 (N-[(2S)-2-hydroxypropyl]-4-{[2-phenyl-5-(propan-2-...) Show SMILES CC(O)CNC(=O)c1cnccc1Nc1cc(ncc1C(C)C)-c1ccccc1 Show InChI InChI=1S/C23H26N4O2/c1-15(2)18-14-25-21(17-7-5-4-6-8-17)11-22(18)27-20-9-10-24-13-19(20)23(29)26-12-16(3)28/h4-11,13-16,28H,12H2,1-3H3,(H,26,29)(H,24,25,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q2W380HG
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM280362 (N-[(2S)-2-hydroxypropyl]-4-{[2-phenyl-5-(propan-2-...) Show SMILES CC(O)CNC(=O)c1cnccc1Nc1cc(ncc1C(C)C)-c1ccccc1 Show InChI InChI=1S/C23H26N4O2/c1-15(2)18-14-25-21(17-7-5-4-6-8-17)11-22(18)27-20-9-10-24-13-19(20)23(29)26-12-16(3)28/h4-11,13-16,28H,12H2,1-3H3,(H,26,29)(H,24,25,27)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	551	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q2W380HG
					More data for this Ligand-Target Pair
Bone morphogenetic protein 10 (Homo sapiens (Human))	BDBM280362 (N-[(2S)-2-hydroxypropyl]-4-{[2-phenyl-5-(propan-2-...) Show SMILES CC(O)CNC(=O)c1cnccc1Nc1cc(ncc1C(C)C)-c1ccccc1 Show InChI InChI=1S/C23H26N4O2/c1-15(2)18-14-25-21(17-7-5-4-6-8-17)11-22(18)27-20-9-10-24-13-19(20)23(29)26-12-16(3)28/h4-11,13-16,28H,12H2,1-3H3,(H,26,29)(H,24,25,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q2W380HG
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase receptor R3 (Homo sapiens (Human))	BDBM280362 (N-[(2S)-2-hydroxypropyl]-4-{[2-phenyl-5-(propan-2-...) Show SMILES CC(O)CNC(=O)c1cnccc1Nc1cc(ncc1C(C)C)-c1ccccc1 Show InChI InChI=1S/C23H26N4O2/c1-15(2)18-14-25-21(17-7-5-4-6-8-17)11-22(18)27-20-9-10-24-13-19(20)23(29)26-12-16(3)28/h4-11,13-16,28H,12H2,1-3H3,(H,26,29)(H,24,25,27)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q24M98N9
					More data for this Ligand-Target Pair
Activin receptor type-1 (Homo sapiens (Human))	BDBM280362 (N-[(2S)-2-hydroxypropyl]-4-{[2-phenyl-5-(propan-2-...) Show SMILES CC(O)CNC(=O)c1cnccc1Nc1cc(ncc1C(C)C)-c1ccccc1 Show InChI InChI=1S/C23H26N4O2/c1-15(2)18-14-25-21(17-7-5-4-6-8-17)11-22(18)27-20-9-10-24-13-19(20)23(29)26-12-16(3)28/h4-11,13-16,28H,12H2,1-3H3,(H,26,29)(H,24,25,27)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q24M98N9
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1A (Homo sapiens (Human))	BDBM280362 (N-[(2S)-2-hydroxypropyl]-4-{[2-phenyl-5-(propan-2-...) Show SMILES CC(O)CNC(=O)c1cnccc1Nc1cc(ncc1C(C)C)-c1ccccc1 Show InChI InChI=1S/C23H26N4O2/c1-15(2)18-14-25-21(17-7-5-4-6-8-17)11-22(18)27-20-9-10-24-13-19(20)23(29)26-12-16(3)28/h4-11,13-16,28H,12H2,1-3H3,(H,26,29)(H,24,25,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q24M98N9
					More data for this Ligand-Target Pair
Activin receptor type-1B (Homo sapiens (Human))	BDBM280362 (N-[(2S)-2-hydroxypropyl]-4-{[2-phenyl-5-(propan-2-...) Show SMILES CC(O)CNC(=O)c1cnccc1Nc1cc(ncc1C(C)C)-c1ccccc1 Show InChI InChI=1S/C23H26N4O2/c1-15(2)18-14-25-21(17-7-5-4-6-8-17)11-22(18)27-20-9-10-24-13-19(20)23(29)26-12-16(3)28/h4-11,13-16,28H,12H2,1-3H3,(H,26,29)(H,24,25,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q24M98N9
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM280362 (N-[(2S)-2-hydroxypropyl]-4-{[2-phenyl-5-(propan-2-...) Show SMILES CC(O)CNC(=O)c1cnccc1Nc1cc(ncc1C(C)C)-c1ccccc1 Show InChI InChI=1S/C23H26N4O2/c1-15(2)18-14-25-21(17-7-5-4-6-8-17)11-22(18)27-20-9-10-24-13-19(20)23(29)26-12-16(3)28/h4-11,13-16,28H,12H2,1-3H3,(H,26,29)(H,24,25,27)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	551	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q24M98N9
					More data for this Ligand-Target Pair
Activin receptor type-1 (Homo sapiens (Human))	BDBM280362 (N-[(2S)-2-hydroxypropyl]-4-{[2-phenyl-5-(propan-2-...) Show SMILES CC(O)CNC(=O)c1cnccc1Nc1cc(ncc1C(C)C)-c1ccccc1 Show InChI InChI=1S/C23H26N4O2/c1-15(2)18-14-25-21(17-7-5-4-6-8-17)11-22(18)27-20-9-10-24-13-19(20)23(29)26-12-16(3)28/h4-11,13-16,28H,12H2,1-3H3,(H,26,29)(H,24,25,27)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Medivation Technologies LLC US Patent					Assay Description Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...				US Patent US10030004 (2018) BindingDB Entry DOI: 10.7270/Q2QC05HQ
					More data for this Ligand-Target Pair