BDBM280368 2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-yl)-N-[3-(pyrrolidine-1-carbonyl)pyridin-4-yl]pyridin-4-amine::US10030004, Compound 34::US10501436, Compound 34
SMILES: CC(=C)c1cnc(cc1Nc1ccncc1C(=O)N1CCCC1)-c1cc(Cl)ccc1F
InChI Key: InChIKey=FHRZBVSUXBSDPP-UHFFFAOYSA-N
Data: 12 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Serine/threonine-protein kinase receptor R3 (Homo sapiens (Human)) | BDBM280368 (2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-yl)-N-[...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Medivation Technologies LLC US Patent | Assay Description Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t... | US Patent US10030004 (2018) BindingDB Entry DOI: 10.7270/Q2QC05HQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bone morphogenetic protein 10 (Homo sapiens (Human)) | BDBM280368 (2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-yl)-N-[...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor-like kinase 3 (ALK-3) (Homo sapiens (Human)) | BDBM280368 (2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-yl)-N-[...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Medivation Technologies LLC US Patent | Assay Description Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t... | US Patent US10030004 (2018) BindingDB Entry DOI: 10.7270/Q2QC05HQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1B (Homo sapiens (Human)) | BDBM280368 (2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-yl)-N-[...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 149 | n/a | n/a | n/a | n/a | n/a | n/a |
Medivation Technologies LLC US Patent | Assay Description Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t... | US Patent US10030004 (2018) BindingDB Entry DOI: 10.7270/Q2QC05HQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 (Homo sapiens (Human)) | BDBM280368 (2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-yl)-N-[...) | PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 77.3 | n/a | n/a | n/a | n/a | n/a | n/a |
Medivation Technologies LLC US Patent | Assay Description Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t... | US Patent US10030004 (2018) BindingDB Entry DOI: 10.7270/Q2QC05HQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bone morphogenetic protein receptor type-1B (Mus musculus (Mouse)) | BDBM280368 (2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-yl)-N-[...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Medivation Technologies LLC US Patent | Assay Description Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t... | US Patent US10030004 (2018) BindingDB Entry DOI: 10.7270/Q2QC05HQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase receptor R3 (Homo sapiens (Human)) | BDBM280368 (2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-yl)-N-[...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Medivation Technologies LLC US Patent | Assay Description Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t... | US Patent US10501436 (2019) BindingDB Entry DOI: 10.7270/Q20867PH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1 (Homo sapiens (Human)) | BDBM280368 (2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-yl)-N-[...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Medivation Technologies LLC US Patent | Assay Description Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t... | US Patent US10501436 (2019) BindingDB Entry DOI: 10.7270/Q20867PH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor-like kinase 3 (ALK-3) (Homo sapiens (Human)) | BDBM280368 (2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-yl)-N-[...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Medivation Technologies LLC US Patent | Assay Description Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t... | US Patent US10501436 (2019) BindingDB Entry DOI: 10.7270/Q20867PH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1B (Homo sapiens (Human)) | BDBM280368 (2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-yl)-N-[...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 149 | n/a | n/a | n/a | n/a | n/a | n/a |
Medivation Technologies LLC US Patent | Assay Description Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t... | US Patent US10501436 (2019) BindingDB Entry DOI: 10.7270/Q20867PH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 (Homo sapiens (Human)) | BDBM280368 (2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-yl)-N-[...) | PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 77.3 | n/a | n/a | n/a | n/a | n/a | n/a |
Medivation Technologies LLC US Patent | Assay Description Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t... | US Patent US10501436 (2019) BindingDB Entry DOI: 10.7270/Q20867PH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bone morphogenetic protein receptor type-1B (Homo sapiens (Human)) | BDBM280368 (2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-yl)-N-[...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Medivation Technologies LLC US Patent | Assay Description Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t... | US Patent US10501436 (2019) BindingDB Entry DOI: 10.7270/Q20867PH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase receptor R3 (Homo sapiens (Human)) | BDBM280368 (2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-yl)-N-[...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1 (Homo sapiens (Human)) | BDBM280368 (2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-yl)-N-[...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor-like kinase 3 (ALK-3) (Homo sapiens (Human)) | BDBM280368 (2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-yl)-N-[...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1B (Homo sapiens (Human)) | BDBM280368 (2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-yl)-N-[...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | n/a | n/a | 149 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 (Homo sapiens (Human)) | BDBM280368 (2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-yl)-N-[...) | PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | n/a | n/a | 77.3 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1 (Homo sapiens (Human)) | BDBM280368 (2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-yl)-N-[...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Medivation Technologies LLC US Patent | Assay Description Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t... | US Patent US10030004 (2018) BindingDB Entry DOI: 10.7270/Q2QC05HQ | |||||||||||
More data for this Ligand-Target Pair |