BDBM28040 4-(4-phenylphenoxy)thieno[2,3-c]pyridine-2-carboxylic acid::thieno[2,3-c]pyridine, 5
SMILES: OC(=O)c1cc2c(Oc3ccc(cc3)-c3ccccc3)cncc2s1
InChI Key: InChIKey=ZKPZZOFVDONWEO-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human)) | BDBM28040 (4-(4-phenylphenoxy)thieno[2,3-c]pyridine-2-carboxy...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 310 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Abbott Laboratories | Assay Description The COT direct HTRF assay was carried out using biotin-MEK1 as a substrate. The reaction was carried out in black 96 half-well plates. At designated... | Bioorg Med Chem Lett 19: 1722-5 (2009) Article DOI: 10.1016/j.bmcl.2009.01.088 BindingDB Entry DOI: 10.7270/Q2VH5M4P | |||||||||||
More data for this Ligand-Target Pair |