BDBM280413 US10030012, Example 43::ethyl 4-{4-[2- methoxy-5- (trifluoro- methyl)pyridin- 3-yl]piperidin-1- yl}azepane-1- carboxylate
SMILES: CCOC(=O)N1CCCC(CC1)N1CCC(CC1)c1cc(cnc1OC)C(F)(F)F
InChI Key: InChIKey=DISBBHRZWUEUSE-UHFFFAOYSA-N
Data: 2 EC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Muscarinic acetylcholine receptor M2 (Homo sapiens (Human)) | BDBM280413 (US10030012, Example 43 | ethyl 4-{4-[2- methoxy-5-...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 180 | n/a | n/a | n/a | n/a |
Heptares Therapeutics Limited US Patent | US Patent US10030012 (2018) BindingDB Entry DOI: 10.7270/Q2KK9DTW | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor M4 (Homo sapiens (Human)) | BDBM280413 (US10030012, Example 43 | ethyl 4-{4-[2- methoxy-5-...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 20 | n/a | n/a | n/a | n/a |
Heptares Therapeutics Limited US Patent | Assay Description The functional activity of compounds at the M4 and M2 receptors was determined by measuring changes in the level of intracellular calcium ions caused... | US Patent US10030012 (2018) BindingDB Entry DOI: 10.7270/Q2KK9DTW | |||||||||||
More data for this Ligand-Target Pair |