BDBM28046 (4Z)-6-bromo-4-({[4-(pyrrolidin-1-ylmethyl)phenyl]amino}methylidene)-1,2,3,4-tetrahydroisoquinoline-1,3-dione::isoquinolinedione, 1
SMILES: Brc1ccc2C(=O)NC(=O)C(=CNc3ccc(CN4CCCC4)cc3)c2c1
InChI Key: InChIKey=JFEKAVPMVOLVTH-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Insulin-like growth factor I receptor (Homo sapiens (Human)) | BDBM28046 ((4Z)-6-bromo-4-({[4-(pyrrolidin-1-ylmethyl)phenyl]...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 2.42E+3 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Wyeth Research | Assay Description Assays were performed in microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of test com... | Bioorg Med Chem Lett 18: 3641-5 (2008) Article DOI: 10.1016/j.bmcl.2008.04.044 BindingDB Entry DOI: 10.7270/Q2QR4VFD | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |