BDBM280884 (S)-3-(4-{4-amino- 2-[6-chloro-1- (cyclopentylmethyl)- 1H-indazol-3-yl]- 5-methyl-6-oxo- 6,7-dihydro-5H- pyrrolo[2,3-d] pyrimidin-5-yl} phenyl)propanoic acid::US10030027, Example 160B::US10428076, Example 160B

SMILES: C[C@]1(C(=O)Nc2nc(nc(N)c12)-c1nn(CC2CCCC2)c2cc(Cl)ccc12)c1ccc(CCC(O)=O)cc1

InChI Key: InChIKey=NLAGHKNECZSRSL-LJAQVGFWSA-N

Data: 2 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 280884   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Soluble Guanylate Cyclases (Homo sapiens (Human))	BDBM280884 ((S)-3-(4-{4-amino- 2-[6-chloro-1- (cyclopentylmeth...) Show SMILES C[C@]1(C(=O)Nc2nc(nc(N)c12)-c1nn(CC2CCCC2)c2cc(Cl)ccc12)c1ccc(CCC(O)=O)cc1 |r| Show InChI InChI=1S/C29H29ClN6O3/c1-29(18-9-6-16(7-10-18)8-13-22(37)38)23-25(31)32-27(33-26(23)34-28(29)39)24-20-12-11-19(30)14-21(20)36(35-24)15-17-4-2-3-5-17/h6-7,9-12,14,17H,2-5,8,13,15H2,1H3,(H,37,38)(H3,31,32,33,34,39)/t29-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0620	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The binding buffer was composed of 50 mM triethanolamine, pH 7.4, 3 mM MgCl2, 0.025% BSA, 2 mM dithiothreitol (DTT), 300 μM DETA/NO and 400 _...				US Patent US10428076 (2019) BindingDB Entry DOI: 10.7270/Q22N54P9
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1 (Homo sapiens (Human))	BDBM280884 ((S)-3-(4-{4-amino- 2-[6-chloro-1- (cyclopentylmeth...) Show SMILES C[C@]1(C(=O)Nc2nc(nc(N)c12)-c1nn(CC2CCCC2)c2cc(Cl)ccc12)c1ccc(CCC(O)=O)cc1 |r| Show InChI InChI=1S/C29H29ClN6O3/c1-29(18-9-6-16(7-10-18)8-13-22(37)38)23-25(31)32-27(33-26(23)34-28(29)39)24-20-12-11-19(30)14-21(20)36(35-24)15-17-4-2-3-5-17/h6-7,9-12,14,17H,2-5,8,13,15H2,1H3,(H,37,38)(H3,31,32,33,34,39)/t29-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0620	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...				US Patent US10030027 (2018) BindingDB Entry DOI: 10.7270/Q22N549C
					More data for this Ligand-Target Pair