BDBM280980 6-{4-Amino-2-[6-chloro-1-(2-fluorobenzyl)-1H-indazol-3-yl]-5-methyl-6-oxo-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-5-yl}picolinic acid::US10030027, Example 255A::US10428076, Example 255A

SMILES: CC1(C(=O)Nc2nc(nc(N)c12)-c1nn(Cc2ccccc2F)c2cc(Cl)ccc12)c1cccc(n1)C(O)=O

InChI Key: InChIKey=BTANJPGKTCCBKZ-UHFFFAOYSA-N

Data: 2 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 280980   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Soluble Guanylate Cyclases (Homo sapiens (Human))	BDBM280980 (6-{4-Amino-2-[6-chloro-1-(2-fluorobenzyl)-1H-indaz...) Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1nn(Cc2ccccc2F)c2cc(Cl)ccc12)c1cccc(n1)C(O)=O Show InChI InChI=1S/C27H19ClFN7O3/c1-27(19-8-4-7-17(31-19)25(37)38)20-22(30)32-24(33-23(20)34-26(27)39)21-15-10-9-14(28)11-18(15)36(35-21)12-13-5-2-3-6-16(13)29/h2-11H,12H2,1H3,(H,37,38)(H3,30,32,33,34,39)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0730	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The binding buffer was composed of 50 mM triethanolamine, pH 7.4, 3 mM MgCl2, 0.025% BSA, 2 mM dithiothreitol (DTT), 300 μM DETA/NO and 400 _...				US Patent US10428076 (2019) BindingDB Entry DOI: 10.7270/Q22N54P9
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1 (Homo sapiens (Human))	BDBM280980 (6-{4-Amino-2-[6-chloro-1-(2-fluorobenzyl)-1H-indaz...) Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1nn(Cc2ccccc2F)c2cc(Cl)ccc12)c1cccc(n1)C(O)=O Show InChI InChI=1S/C27H19ClFN7O3/c1-27(19-8-4-7-17(31-19)25(37)38)20-22(30)32-24(33-23(20)34-26(27)39)21-15-10-9-14(28)11-18(15)36(35-21)12-13-5-2-3-6-16(13)29/h2-11H,12H2,1H3,(H,37,38)(H3,30,32,33,34,39)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0730	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...				US Patent US10030027 (2018) BindingDB Entry DOI: 10.7270/Q22N549C
					More data for this Ligand-Target Pair